Faculty Opinions recommendation of Biopsy Core Features are Poor Predictors of Adverse Pathology in Men with Grade Group 1 Prostate Cancer.

2017 ◽  
Author(s):  
Thomas Polascik ◽  
Ali Amin Sharifi
Keyword(s):  
Prostate Cancer ◽  
Grade Group ◽  
Biopsy Core ◽  
Core Features ◽  
Group 1

scholarly journals Biopsy Core Features are Poor Predictors of Adverse Pathology in Men with Grade Group 1 Prostate Cancer

2018 ◽  
Vol 199 (4) ◽  
pp. 961-968 ◽  
Author(s):  
François Audenet ◽  
Emily A. Vertosick ◽  
Samson W. Fine ◽  
Daniel D. Sjoberg ◽  
Andrew J. Vickers ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Grade Group ◽  
Biopsy Core ◽  
Core Features ◽  
Group 1

scholarly journals Patient-level detection of grade group ≥2 prostate cancer using quantitative diffusion MRI

2021 ◽  
Author(s):  
Allison Y Zhong ◽  
Leonardino A Digma ◽  
Troy Hussain ◽  
Christine H Feng ◽  
Christopher C Conlin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Characteristic Curve ◽  
Grade Group ◽  
Bootstrap Confidence Intervals ◽  
Patient Level ◽  
Apparent Diffusion ◽  
Spectrum Imaging ◽  
Group 2 ◽  
Clinically Significant ◽  
Group 1

Purpose: Multiparametric MRI (mpMRI) improves detection of clinically significant prostate cancer (csPCa), but the qualitative PI-RADS system and quantitative apparent diffusion coefficient (ADC) yield inconsistent results. An advanced Restrictrion Spectrum Imaging (RSI) model may yield a better quantitative marker for csPCa, the RSI restriction score (RSIrs). We evaluated RSIrs for patient-level detection of csPCa. Materials and Methods: Retrospective analysis of men who underwent mpMRI with RSI and prostate biopsy for suspected prostate cancer from 2017-2019. Maximum RSIrs within the prostate was assessed by area under the receiver operating characteristic curve (AUC) for discriminating csPCa (grade group ≥2) from benign or grade group 1 biopsies. Performance of RSIrs was compared to minimum ADC and PI-RADS v2-2.1via bootstrap confidence intervals and bootstrap difference (two-tailed α=0.05). We also tested whether the combination of PI-RADS and RSIrs (PI-RADS+RSIrs) was superior to PI-RADS, alone. Results: 151 patients met criteria for inclusion. AUC values for ADC, RSIrs, and PI-RADS were 0.50 [95% confidence interval: 0.41, 0.60], 0.76 [0.68, 0.84], and 0.78 [0.71, 0.85], respectively. RSIrs (p=0.0002) and PI-RADS (p<0.0001) were superior to ADC for patient-level detection of csPCa. The performance of RSIrs was comparable to that of PI-RADS (p=0.6). AUC for PI-RADS+RSIrs was 0.84 [0.77, 0.90], superior to PI-RADS or RSIrs, alone (p=0.008, p=0.009). Conclusions: RSIrs was superior to conventional ADC and comparable to (routine, clinical) PI-RADS for patient-level detection of csPCa. The combination of PI-RADS and RSIrs was superior to either alone. RSIrs is a promising quantitative marker worthy of prospective study in the setting of csPCa detection.

scholarly journals PD50-04 UTILITY OF MULTIPARAMETRIC MRI IN THE RISK STRATIFICATION OF MEN WITH GRADE GROUP 1 PROSTATE CANCER ON ACTIVE SURVEILLANCE

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Mufaddal Mamawala* ◽  
Alexa Meyer ◽  
Patricia Landis ◽  
Katarzyna Macura ◽  
Jonathan Epstein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Stratification ◽  
Active Surveillance ◽  
Multiparametric Mri ◽  
Grade Group ◽  
Group 1

Occurrence of pathologic stage T3 disease at radical prostatectomy with isup grade group 1 (Gleason 3+3=6) prostate cancer.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 21-21
Author(s):  
David Theodore Greenwald ◽  
Alice Y. Wang ◽  
Jason Huang ◽  
Harpreet Wadhwa ◽  
Tony Nimeh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymphovascular Invasion ◽  
Metastatic Potential ◽  
Grade Group ◽  
Medical Centers ◽  
Academic Medical ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Patterns Of Behavior ◽  
Group 1

21 Background: Treatment of ISUP Grade Group 1 (Gleason 3+3 = 6) disease continues to evolve in the modern era. We examined our surgical database to investigate patterns of behavior in this pathologic subset. Methods: We reviewed the results of 1127 consecutive radical prostatectomies performed by our surgeons from 2012−2015 at various community and academic medical centers in Chicagoland. Specifically, we examined the ISUP Grade Group 1 (Gleason 3+3 = 6) patients in our database, 314 patients overall. Results: A review of our database revealed that of ISUP Grade Group 1 (Gleason 3+3 = 6) patients (n = 314), only 3.82% had pT3 disease (11 patients stage pT3a and 1 stage pT3b). The only patient of these 12 to have lymphovascular invasion (LVI) was the singular pT3b patient. Overall, ISUP Grade Group 1 (Gleason 3+3 = 6) pT3 disease represents only 1.06% of all prostatectomies in our database. Conclusions: In our large prostatectomy cohort, ISUP Grade Group 1 (Gleason 3+3 = 6) prostate cancer was rarely associated with extra−prostatic extension (pT3) or lymphovascular invasion (LVI), suggesting that it has very low metastatic potential. These findings give further support to the trend of increased utilization of active surveillance for low risk prostate cancer.

A nationwide trend away from radical prostatectomy for Gleason grade group 1 prostate cancer

2021 ◽  
Author(s):  
Joseph B John ◽  
John Pascoe ◽  
Sarah Fowler ◽  
Thomas Walton ◽  
Mark Johnson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Grade ◽  
Grade Group ◽  
Group 1

scholarly journals Increased Body Mass Index Is a Risk Factor for Poor Clinical Outcomes after Radical Prostatectomy in Men with International Society of Urological Pathology Grade Group 1 Prostate Cancer Diagnosed with Systematic Biopsies

2021 ◽  
pp. 1-8
Author(s):  
Matteo Ferro ◽  
Daniela Terracciano ◽  
Gennaro Musi ◽  
Ottavio de Cobelli ◽  
Mihai Dorin Vartolomei ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Risk Factor ◽  
Radical Prostatectomy ◽  
Body Mass ◽  
International Society ◽  
Specific Antigen ◽  
Characteristic Analysis ◽  
Grade Group ◽  
Group 1

<b><i>Introduction:</i></b> The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect of body mass index (BMI) on the prediction of pathological unfavorable disease (UD), positive surgical margins (PSMs), and biochemical recurrence (BCR) in patients with clinically localized (≤cT2c) International Society of Urological Pathology (ISUP) grade group 1 PCa at biopsy. <b><i>Methods:</i></b> 427 patients with ISUP grade group 1 PCa who have undergone radical prostatectomy and BMI evaluation were included. The outcome of interest was the presence of UD (defined as ISUP grade group ≥3 and pT ≥3a), PSM, and BCR. <b><i>Results:</i></b> Statistically significant differences resulted in comparing BMI with prostate-specific antigen (PSA) and serum testosterone levels (both <i>p</i> &#x3c; 0.0001). Patients with UD and PSM had higher BMI values (<i>p</i> &#x3c; 0.0001 and <i>p</i> = 0.006, respectively). BCR-free survival was significantly decreased in patients with higher BMI values (<i>p</i> &#x3c; 0.0001). BMI was an independent risk factor for BCR and PSM. Receiver-operating characteristic analysis testing PSA accuracy in different BMI groups, showed that PSA had a reduced predictive value (area under the curve [AUC] = 0.535; 95% confidence interval [CI] = 0.422–0.646), in obese men compared to overweight (AUC = 0.664; 95% CI = 0.598–0.725) and normal weight patients (AUC = 0.721; 95% CI = 0.660–0.777). <b><i>Conclusion:</i></b> Our findings show that increased BMI is a significant predictor of UD and PSM at RP in patients with preoperative low-to intermediate-risk diseases, suggesting that BMI evaluation may be useful in a clinical setting to identify patients with favorable preoperative disease characteristics harboring high-risk PCa.

scholarly journals How Much Reliable Is the Current Belief on Grade Group 1 Prostate Cancer?

2021 ◽  
Vol 27 ◽  
Author(s):  
Mun Su Chung ◽  
Yeong Jin Choi ◽  
Young Sub Lee ◽  
Byung Il Yoon ◽  
U-Syn Ha
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Treatment Options ◽  
Clinicopathological Characteristics ◽  
Pathological Features ◽  
Grade Group ◽  
Asian Populations ◽  
Current Belief ◽  
Extraprostatic Extension ◽  
Group 1

Objective: To evaluate the clinicopathological characteristics of grade group 1 (GG1) prostate cancer in Korean populations.Methods: We retrospectively analyzed 492 consecutive radical prostatectomy specimens from our institution, which included those from 322 men with clinical GG1 and 170 with clinical GG2 tumors between years 2009 and 2018. The incidence of Gleason score (GS) upgrading, extraprostatic extension (EPE), and seminal vesicle invasion (SVI) were evaluated in patients with clinical GG1. In pathological GG1 cases, the distribution of adverse pathological features including EPE, lymphovascular invasion (LVI), perineural invasion (PNI), and biochemical recurrence (BCR) was analyzed.Results: Altogether, 78 (24.2%) out of 322 men in the clinical GG1 group demonstrated upgrading of GS, including 19 men with pathological Gleason score 4 + 3 = 7 and 6 with ≥ pathological Gleason score 4 + 4 = 8 cases. EPE was found in 37 (11.5%) and 22 (8.9%) men in clinical GG1 and pathological GG1 group, respectively. The incidence of LVI and PNI in the pathological GG1 cases was 2.8% (n = 7) and 28.6% (n = 71), respectively. BCR was observed in 4 men in pathological GG1 T2 (n = 226) and 2 men in GG1 T3 (n = 22) group. When we compared the pathological features between pathological GG1 T3 vs. GG2 T2, there was no statistical differences in the incidence of LVI and PNI between the two groups.Conclusions: Contrary to the current concept that GG1 is almost always clinically insignificant, it seems that GG1 still possess its respectable position as a group of cancer with aggressiveness. These findings should be kept in mind when deciding on treatment options for prostate cancer patients in the Asian populations.

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