scholarly journals Faculty Opinions recommendation of Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis.

2019 ◽  
Author(s):  
Harald Brüssow
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Infantile Colic

scholarly journals Lactobacillus Reuteri DSM 17938 in Infantile Colic: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 6 (3) ◽  
pp. 1446-1454
Author(s):  
Burhannudin Ichsan ◽  
Nining Lestari ◽  
Sulistyani
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Forest Plot ◽  
Infantile Colic ◽  
Eligibility Criteria ◽  
Randomized Controlled ◽  
Infant Colic ◽  
Systematic Synthesis

Background. Infantile colic, defined as paroxysmal, excessive, and consolable crying without an identifiable cause. It is common in the first 3 months of life. There have been many RCT studies conducted. A systematic synthesis is required to summarize the results of these RCTs. This study was aimed to systematically analyze the benefits of Lactobacillus reuteri DSM 17938 for infantile colic. Methods. This systematic review and meta-analysis used keywords: (“infantile colic” OR “abdominal cramps” OR “abdominal cramp” OR “infant colic”) AND “lactobacillus reuteri” AND (placebo OR placebos) AND (“randomized controlled trial” OR RCT). The databases used were: pubmed, science direct, and google scholar. Meta-analysis was conducted to combine the articles. The eligibility criteria were: patient with infantile colic, intervention with L. reuteri DSM 17938, control was placebo, RCT study design, outcome with dichotomous scale, all races, all ethnicities, all countries, all genders, in English, and not limited by year. Results. The search resulted in 800 articles. After reducing duplication, the number of articles was 747. Screening with titles and abstracts resulted in 13 full teks articles. Six articles fitted the eligibility criteria. The results of the meta-analysis were as follows. The forest plot showed that the combined effect of the six articles showed an RR of 0.47 and was statistically significant (p <0.001). Conclusion. Based on the results of this meta-analysis, L. reuteri DSM 17938 is recommended for infants with infantile colic. There were no significant side effects with the use of L. reuteri DSM 17938 on infantile colic.

Probiotics for the Treatment of Infantile Colic: A Systematic Review

2016 ◽  
Vol 30 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Anna Schreck Bird ◽  
Philip J. Gregory ◽  
Mohamed A. Jalloh ◽  
Zara Risoldi Cochrane ◽  
Darren J. Hein
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Infantile Colic ◽  
Probiotic Supplementation ◽  
Breastfed Infants ◽  
Healthy Infants ◽  
Potential Strategy ◽  
Different Strains ◽  
Specific Species

Objective: To evaluate whether clinical data support the safety and efficacy of probiotics for the management of infantile colic. Background: Probiotics have been suggested as a potential strategy for infantile colic, and the specific species that have been studied in healthy infants are considered to be safe. Methodology: A systematic review was conducted to identify randomized controlled trials (RCTs) evaluating the use of probiotic supplementation in infants with colic. RCTs with a primary end point assessing crying or fussing time were selected. A meta-analysis comparing “responders” to “nonresponders” in infants receiving probiotic versus control was conducted. The quality of trials selected was assessed. Results: Five RCTs assessing 2 different strains of the probiotic Lactobacillus reuteri in mostly breastfed infants were identified. Analysis of response rates showed that infants receiving probiotics had a 2.3-fold greater chance of having a 50% or greater decrease in crying/fussing time compared to controls ( P = .01). Probiotic supplementation was not associated with any adverse events. Conclusion: Supplementation with the probiotic L. reuteri in breastfed infants appears to be safe and effective for the management of infantile colic. Further research is needed to determine the role of probiotics in infants who are formula-fed.

scholarly journals The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

2020 ◽  
Vol 9 (4) ◽  
pp. 999 ◽  
Author(s):  
Karolina Skonieczna-Żydecka ◽  
Katarzyna Janda ◽  
Mariusz Kaczmarczyk ◽  
Wojciech Marlicz ◽  
Igor Łoniewski ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Intervention Group ◽  
Intestinal Microbiome ◽  
Infantile Colic ◽  
Breastfed Infants ◽  
Mean Differences ◽  
Meta Analyses ◽  
The Impact

Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. Lactobacillus reuteri strain DSM17938 was administered predominantly (n = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, p < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, p < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed.

scholarly journals Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis

2021 ◽  
pp. 102781
Author(s):  
Angela Pierina dos Reis Buzzo Zermiani ◽  
Ana Luiza Pelissari Peçanha de Paula Soares ◽  
Bárbara Leticia da Silva Guedes de Moura ◽  
Edson Roberto Arpini Miguel ◽  
Luciana Dias Ghiraldi Lopes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Meta Analysis

scholarly journals Does probiotics reduce crying time in infantile colic in exclusively breastfed babies? A comprehensive meta-analysis

2018 ◽  
Vol 9 (1) ◽  
pp. 245-247
Author(s):  
Kamrul Hassan Shabuj ◽  
Chandan Kumar Shaha ◽  
Jesmin Hossain
Keyword(s):  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Treatment Options ◽  
Final Analysis ◽  
Mean Difference ◽  
Infantile Colic ◽  
Medical College ◽  
Breastfed Infants ◽  
Young Infants ◽  
Initiation Of Therapy

Background : Infantile colic is one of the common pediatric problems that Pediatricians encounter in practice. This condition is associated with excessive crying in healthy thriving infants over a regular period during the day and is sustained for the first few months of life. It has been historically described as irritable or compulsive crying or paroxysmal fussing with multifactorial etiology. Although it affects 5-19% of young infants, it remains a frustrating problem for parents and caregivers, because it is difficult to treat and may result in significant psychosocial consequences. Different treatment options are available with no definitive and conclusive benefit. In this metaanalysis, we pooled relevant data regarding the use of probiotics in infantile colic and tried to find out any beneficial effect thereof.Objective : To evaluate the efficacy of probiotics supplementation in the reduction of the duration of crying time in infantile colic.Method : It is a comprehensive meta-analytic study where literature searches were conducted in the Pubmed using end note package and Google scholar. Randomized controlled trials those enrolled healthy, term breastfed infants with infantile colic were included for analysis. After meticulous scrutiny for methods and study population, five studies with a total of 384 breastfed infants were selected for final analysis. All these studies used Lactobacillus reuteri DSM 17938 as probiotics in the therapeutic intervention and supplementation of this was compared to placebo.Result : Analysis of pooled data showed that at Initiation of therapy mean difference of crying time 0.29 minutes; 95% CI-6.61, 7.20, p=0.89, after 3weeks of probiotics therapy mean difference of crying time -30.64, 95% CI- 34.48, -26.81, p=0.0001.Conclusions : Probiotics use for 3 weeks significantly reduced the duration of crying time in exclusively breastfed infants suffering from infantile colic.Northern International Medical College Journal Vol.9(1) July 2017: 245-247

scholarly journals Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2762 ◽  
Author(s):  
Bernadeta Patro-Gołąb ◽  
Hania Szajewska
Keyword(s):  
Systematic Review ◽  
Acute Gastroenteritis ◽  
Additional Data ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Cochrane Library ◽  
Duration Of Hospitalization ◽  
The Cochrane Library ◽  
Stool Volume

The effectiveness of Lactobacillus reuteri DSM 17938 (L. reuteri) for the management of acute gastroenteritis (AGE) has been recently questioned. We performed a systematic review to update evidence on L. reuteri for treating AGE in children. We searched MEDLINE, EMBASE, the Cochrane Library databases, and additional data sources from January 2016 (end of search for our 2016 systematic review) to August 2019. The primary outcomes were stool volume and duration of diarrhea. Four RCTs were included. None of them evaluated stool volume. Compared with placebo or no treatment, L. reuteri reduced diarrhea duration (four RCTs, n = 347, mean difference, MD −0.87 days, 95% CI [−1.43, −0.31]). L. reuteri use was also associated with a reduced duration of hospitalization (three RCTs, n = 284, MD −0.54 days, 95% CI [−1.09, 0.0]). The small effect sizes of limited clinical relevance and methodological limitations of the included trials should be noted when interpreting these findings.

scholarly journals Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis

2018 ◽  
Author(s):  
Pedro Gutierrez-Castrellon ◽  
Zvi Weizman ◽  
Silvia Cruchet ◽  
Ener Cagri Dinleyci ◽  
Carlos Jimenez-Gutierrez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Respiratory Infections ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Forest Plot ◽  
Upper Respiratory Infections ◽  
Standard Mean Difference ◽  
Upper Respiratory

Background. Upper respiratory infections (URIs) remains as significant cause of morbidity in children. Evidence on efficacy of probiotics to prevent URIs in children is increasing. This systematic review was assembled to analyze evidence about the efficacy of probiotics to reduce duration of upper respiratory infections in ambulatory children. Methods. Randomized controlled trials (RCTs) comparing probiotics vs. placebo to prevent URIs, published between 2001 and 2016 were considered. Quality evaluation was evaluated using CONSORT. Standard mean difference (SMD) or risk ratio (RR) was calculated. Network Meta-Analysis (NMA), using a random effect model was assembled. Results. 31 RCTs were evaluated and 20 studies were included with 3,635 children randomized to probiotics and 3,433 to placebo. Lactobacillus reuteri [SMD -0.56 CI95% (-0.72 to -0.41), p 0.0001] and Lactobacillus acidophillus [SMD -0.33 CI95% (-0.60 to -0.06), p 0.01] were superior to placebo to reduce duration of URIs. L. rhamnosus GG showed tendency [SMD -0.14 CI95% (-0.28 to 0.0), p 0.048]. On the network forest plot L. reuteri showed preventive equivalence when was compared to L. rhamnosus GG, L. casei and BB12. Conclusions. Lactobacillus reuteri, Lactobacillus rhamnosus GG and Bifidobacterium BB12 are evidence-based alternatives to be considered to prevent URIs in children.

Sign in / Sign up

Export Citation Format

Share Document