Faculty Opinions recommendation of Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.

2018 ◽  
Author(s):  
Honorine Ward
Keyword(s):  
Acute Diarrhea ◽  
Therapeutic Efficacy ◽  
Kinase Inhibitor ◽  
Pig Model ◽  
Cryptosporidium Hominis ◽  
Bumped Kinase Inhibitor

scholarly journals Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused byCryptosporidium hominis

2018 ◽  
Vol 62 (7) ◽  
pp. e00147-18 ◽  
Author(s):  
Sangun Lee ◽  
Melanie Ginese ◽  
Gillian Beamer ◽  
Hillary R. Danz ◽  
Donald J. Girouard ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Kinase Inhibitor ◽  
Day Treatment ◽  
Parasite Burden ◽  
Symptomatic Improvement ◽  
Control Measures ◽  
Pig Model ◽  
Cryptosporidium Hominis ◽  
Content Type ◽  
Bumped Kinase Inhibitor

ABSTRACTRecent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute diarrhea caused byCryptosporidium hominis, the species responsible for most human cases. Five-day treatment with BKI 1369 reduced signs of disease early during treatment compared to those of untreated animals. Piglets treated with BKI 1369 exhibited significant reductions of oocyst excretion, mucosal colonization byC. hominis, and mucosal lesions, which resulted in considerable symptomatic improvement. BKI 1369 reduced the parasite burden and disease severity in the gnotobiotic pig model. Together these data suggest that a BKI-mediated therapeutic may be an effective treatment against cryptosporidiosis.

scholarly journals The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185906 ◽  
Author(s):  
Sangun Lee ◽  
Melanie Harwood ◽  
Don Girouard ◽  
Marvin J. Meyers ◽  
Mary A. Campbell ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Pig Model ◽  
Cryptosporidium Hominis

Antiinflammatory Effects of Genistein, a Tyrosine Kinase Inhibitor, on a Guinea Pig Model of Asthma

2003 ◽  
Vol 167 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Wei Duan ◽  
I. Chun Kuo ◽  
Sathiyamoorthy Selvarajan ◽  
Kaw Yan Chua ◽  
Boon Huat Bay ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Pig Model ◽  
Guinea Pig Model ◽  
Antiinflammatory Effects

scholarly journals Comparison of the Therapeutic Efficacy of Oral Doses of Fluconazole and Griseofulvin in a Guinea Pig Model of Dermatophytosis.

2000 ◽  
Vol 53 (2) ◽  
pp. 207-210 ◽  
Author(s):  
KENJI NAGINO ◽  
HIROSHI SHIMOHIRA ◽  
MASATOSHI OGAWA ◽  
KATSUHISA UCHIDA ◽  
HIDEYO YAMAGUCHI
Keyword(s):  
Guinea Pig ◽  
Therapeutic Efficacy ◽  
Pig Model ◽  
Guinea Pig Model ◽  
Oral Doses

scholarly journals Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

2007 ◽  
Vol 67 (22) ◽  
pp. 10976-10983 ◽  
Author(s):  
Jyotsnabaran Halder ◽  
Yvonne G. Lin ◽  
William M. Merritt ◽  
Whitney A. Spannuth ◽  
Alpa M. Nick ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Therapeutic Efficacy ◽  
Kinase Inhibitor

scholarly journals A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice

2016 ◽  
Vol 214 (12) ◽  
pp. 1850-1855 ◽  
Author(s):  
Alejandro Castellanos-Gonzalez ◽  
Hayley Sparks ◽  
Samantha Nava ◽  
Wenlin Huang ◽  
Zhongsheng Zhang ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Calcium Dependent ◽  
Bumped Kinase Inhibitor ◽  
Immunosuppressed Mice

Abstract 3837: Bumped kinase inhibitor 1553 selectively inhibits androgen receptor positive prostate cancer

2018 ◽  
Author(s):  
Takuma Uo ◽  
Shihua Sun ◽  
Kathleen Haugk ◽  
Kathryn Soriano Epilepsia ◽  
Mamatha Damodarasamy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Kinase Inhibitor ◽  
Bumped Kinase Inhibitor

scholarly journals Bumped kinase inhibitor prohibits egression in Babesia bovis

2016 ◽  
Vol 215 ◽  
pp. 22-28 ◽  
Author(s):  
Monica J. Pedroni ◽  
Rama Subba Rao Vidadala ◽  
Ryan Choi ◽  
Katelyn R. Keyloun ◽  
Molly C. Reid ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Babesia Bovis ◽  
Bumped Kinase Inhibitor

scholarly journals Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection

2014 ◽  
Vol 58 (6) ◽  
pp. 3547-3549 ◽  
Author(s):  
J. Stone Doggett ◽  
Kayode K. Ojo ◽  
Erkang Fan ◽  
Dustin J. Maly ◽  
Wesley C. Van Voorhis
Keyword(s):  
Toxoplasma Gondii ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Content Type ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Orally Bioavailable ◽  
Toxoplasma Gondii Infection ◽  
Bumped Kinase Inhibitor

ABSTRACTToxoplasma gondiiis a unicellular parasite that causes severe brain and eye disease. Current drugs forT. gondiiare limited by toxicity. Bumped kinase inhibitors (BKIs) selectively inhibit calcium-dependent protein kinases of the apicomplexan pathogensT. gondii, cryptosporidia, and plasmodia. A lead anti-ToxoplasmaBKI, 1294, has been developed to be metabolically stable and orally bioavailable. Herein, we demonstrate the oral efficacy of 1294 against toxoplasmosisin vivo.

Sign in / Sign up

Export Citation Format

Share Document