Faculty Opinions recommendation of Diagnostic biomarkers for Parkinson's disease: focus on α-synuclein in cerebrospinal fluid.

2018 ◽  
Author(s):  
Joseph Jankovic ◽  
Arjun Tarakad
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Diagnostic Biomarkers ◽  
Disease Focus

scholarly journals Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis

2018 ◽  
Vol 71 (6) ◽  
pp. 3074-3083
Author(s):  
Maria Fernanda Baeta Neves Alonso da Costa ◽  
Emilene Reisdorfer ◽  
Silvana Silveira Kempfer ◽  
Gisele Cristina Manfrini Fernandes ◽  
André Luís Porporatti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Web Of Science ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Quality Assessment Tool ◽  
Diagnostic Biomarkers ◽  
Gait Abnormality ◽  
Review Manager

ABSTRACT Objective: To identify biomarkers for Parkinson’s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson’s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.

Protein biomarkers in Parkinson's disease: Focus on cerebrospinal fluid markers and synaptic proteins

2016 ◽  
Vol 31 (6) ◽  
pp. 848-860 ◽  
Author(s):  
Steffen Halbgebauer ◽  
Patrick Öckl ◽  
Katharina Wirth ◽  
Petra Steinacker ◽  
Markus Otto
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Synaptic Proteins ◽  
Protein Biomarkers ◽  
Disease Focus

scholarly journals Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease

2021 ◽  
Author(s):  
Thomas Kremer ◽  
Kirsten I. Taylor ◽  
Juliane Siebourg‐Polster ◽  
Thomas Gerken ◽  
Andreas Staempfli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Longitudinal Analysis ◽  
Early Parkinson’S Disease ◽  
Neurotransmitter Metabolites

Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline

2021 ◽  
Author(s):  
Feng Han ◽  
Gregory L. Brown ◽  
Yalin Zhu ◽  
Aaron E. Belkin‐Rosen ◽  
Mechelle M. Lewis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Fluid Flow ◽  
Cognitive Decline ◽  
Brain Activity ◽  
Cerebrospinal Fluid Flow ◽  
Global Brain

Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease

2013 ◽  
Vol 28 (6) ◽  
pp. 747-754 ◽  
Author(s):  
Karin D. van Dijk ◽  
Emanuele Persichetti ◽  
Davide Chiasserini ◽  
Paolo Eusebi ◽  
Tommaso Beccari ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Enzyme Activities
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