Faculty Opinions recommendation of Cyclical fate restriction: a new view of neural crest cell fate specification.

2021 ◽  
Author(s):  
Samantha Brugmann
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Fate Restriction ◽  
Crest Cell ◽  
New View

Cyclical fate restriction: a new view of neural crest cell fate specification

Development ◽  
2021 ◽  
Vol 148 (22) ◽  
Author(s):  
Robert N. Kelsh ◽  
Karen Camargo Sosa ◽  
Saeed Farjami ◽  
Vsevolod Makeev ◽  
Jonathan H. P. Dawes ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Pigment Cell ◽  
Neural Crest Cell ◽  
Neural Crest Cells ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Dynamic View ◽  
Fate Restriction ◽  
Crest Cell

ABSTRACT Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive fate restriction (PFR) and direct fate restriction, differing in whether partially restricted intermediates were involved. Initially hotly debated, they remain unreconciled, although PFR has become favoured. However, testing of a PFR hypothesis of zebrafish pigment cell development refutes this view. We propose a novel ‘cyclical fate restriction’ hypothesis, based upon a more dynamic view of transcriptional states, reconciling the experimental evidence underpinning the traditional hypotheses.

scholarly journals The Hippo pathway member YAP enhances human neural crest cell fate and migration

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Christopher J. Hindley ◽  
Alexandra Larisa Condurat ◽  
Vishal Menon ◽  
Ria Thomas ◽  
Luis M. Azmitia ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Hippo Pathway ◽  
Neural Crest Cell ◽  
And Migration ◽  
The Hippo Pathway ◽  
Crest Cell

scholarly journals Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate

Cell Reports ◽  
2019 ◽  
Vol 29 (3) ◽  
pp. 603-616.e5
Author(s):  
Hiroyuki N. Arai ◽  
Fuminori Sato ◽  
Takuya Yamamoto ◽  
Knut Woltjen ◽  
Hiroshi Kiyonari ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Bmp Signaling ◽  
Cardiac Neural Crest ◽  
Crest Cell

Regulation of cranial neural crest cell fate by Irf6 and Twist1 interaction

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Walid D. Fakhouri ◽  
Jessica Wildgrube Bertol ◽  
Victoria K. Xie ◽  
Shelby Johnston ◽  
Kelsea Hubka ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Crest Cell

scholarly journals Blastula stage specification of avian neural crest

2019 ◽  
Author(s):  
Maneeshi S. Prasad ◽  
Eileen Uribe-Querol ◽  
Jonathan Marquez ◽  
Stephanie Vadasz ◽  
Nathan Yardley ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Regional Identity ◽  
Stem Cell Population ◽  
Chick Embryos ◽  
Intermediate Region ◽  
Fate Map ◽  
Blastula Stage ◽  
Crest Cell

AbstractCell fate specification defines the earliest steps towards a distinct cell lineage. Neural crest, a multipotent stem cell population, is thought to be specified from the ectoderm, but its varied contributions defy canons of segregation potential and challenges its embryonic origin. Aiming to resolve this conflict, we have assayed the earliest specification of neural crest using blastula stage chick embryos. Specification assays on isolated chick epiblast explants identify an intermediate region specified towards the neural crest cell fate. Furthermore, low density culture suggests that the specification of intermediate cells towards the neural crest lineage is independent of contact mediated induction. Finally, we have validated the regional identity of the intermediate region towards the neural crest cell fate using fate map studies in blastula stage chick embryos. Our results suggest a model of neural crest specification at blastula stage, with restricted ectoderm and mesoderm capacities.

scholarly journals Neural Crest Cell Fate

2007 ◽  
Vol 1 (4) ◽  
pp. 199-201 ◽  
Author(s):  
Frances Lefcort ◽  
Lynn George
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Crest Cell

Composite ganglioneuroma-paraganglioma of the filum terminale

2010 ◽  
Vol 12 (6) ◽  
pp. 709-713 ◽  
Author(s):  
Ganesh M. Shankar ◽  
Li Chen ◽  
Albert H. Kim ◽  
Gina L. Ross ◽  
Rebecca D. Folkerth ◽  
...  
Keyword(s):  
Neural Crest ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Immunohistochemical Analysis ◽  
Low Back ◽  
Filum Terminale ◽  
Divergent Differentiation ◽  
History Of ◽  
Crest Cell

Extraadrenal paragangliomas are most commonly found in the carotid body and are also found with lower frequency in the CNS. These lesions are derived from the sympathoadrenal lineage of neural crest cells. Here, the authors report a rare case of a composite paraganglioma with ganglioneuromatous components found at the filum terminale in a patient who presented with a brief history of low-back pain and paresthesias in the inguinal region. Immunohistochemical analysis of the resected lesion revealed admixed elements of neuroendocrine and neuroblastoma lineages, indicating the presence of divergent differentiation of sympathoadrenal progenitor cells. This case represents a unique opportunity to understand the cell fate of sympathoadrenal progenitor cells. Here, the authors propose that paragangliomas at the filum terminale can revert to a neural crest cell precursor fate, giving rise to divergent neoplastic populations.

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