scholarly journals The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis

2021 ◽  
Vol 7 (1) ◽  
pp. e15-e15
Author(s):  
Essam Nour el Din Afifi ◽  
Ahmed Mohamed Tawfik ◽  
Essam Eldin Rashed Saeed Abdulkhalek ◽  
Lina Essam Khedr
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Serum Calcium ◽  
End Stage Renal Disease ◽  
Iron Status ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

Introduction: Anemia is a common complication in end-stage renal disease (ESRD) patients on regular hemodialysis (HD). There has been a lot of interest recently in the non-classical effects of 25(OH) vitamin D (calcidiol), including its association with erythropoiesis and anemia pathogenesis. Objectives: To study the relation between anemia and vitamin D status in patients on regular HD Results: This study is a cross-sectional study that included 90 patients on regular HD. Vitamin D status was classified into deficient (<20 ng/ mL), insufficient (20-30 ng/mL) and sufficient (>30 ng/mL). The level of vitamin D measured in the patients ranged between 3.5 to 66 ng/mL with median of 16.35 ng/mL. There were statistically significant positive correlations between vitamin D levels and the level of hemoglobin (P<0.001), serum calcium levels (P<0.001) and serum PO4 levels (P=0.023). Higher hemoglobin levels were statistically related to both higher vitamin D values (P<0.001) and higher serum calcium concentration P<0.001). Meanwhile, a significant negative correlation was found between hemoglobin levels and serum PTH values (P<0.001). Conclusion: There was a significant association between the status of vitamin D and the level of hemoglobin in dialysis population who were studied, independent from iron status. other associations with hemoglobin levels included PTH level and calcium.

FGF 23, PTH and vitamin D status in end stage renal disease patients affected by VDR Fok I and Bsm I variants

2018 ◽  
Vol 54 ◽  
pp. 42-50 ◽  
Author(s):  
Mouna Bouksila ◽  
Wajih Kaabachi ◽  
Mehdi Mrad ◽  
Wided Smaoui ◽  
Elhem Cheour El Kateb ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vitamin D Status ◽  
Stage Renal Disease ◽  
End Stage ◽  
Fgf 23

scholarly journals Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Cahyani Gita Ambarsari ◽  
Partini Pudjiastuti Trihono ◽  
Agustina Kadaristiana ◽  
Dedi Rachmadi ◽  
Murti Andriastuti ◽  
...  
Keyword(s):  
Treatment Group ◽  
Renal Disease ◽  
Maintenance Therapy ◽  
End Stage Renal Disease ◽  
Comparison Group ◽  
Iron Status ◽  
Iv Iron ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

Iron deficiency anemia is common in children with end-stage renal disease (ESRD) on long-term hemodialysis receiving erythropoiesis-stimulating agents. One approach to maintain the iron profile and hemoglobin levels is maintenance therapy with regular low doses of intravenous (IV) iron after initial iron repletion therapy; however, evidence for the benefits of this approach is lacking. This study evaluated the effect of IV iron maintenance therapy on anemia in children on regular hemodialysis. This retrospective cohort study included 41 pediatric ESRD patients with normal hemoglobin and iron status who underwent regular hemodialysis at the Pediatric Dialysis Unit of Cipto Mangunkusumo Hospital, Indonesia, between January 2015 and April 2019. Among these, 21 received IV iron maintenance therapy with two doses of 2 mg/kg of IV iron sucrose every 2 weeks (the treatment group) and 20 did not (the comparison group). Changes in hemoglobin and transferrin saturation were assessed after 6 weeks of observation and compared between the two groups. There was a significant reduction in the mean hemoglobin level compared with the baseline level in the comparison group (21 g/L; 95% CI, 9.3–33 g/L; p=0.001) but not in the treatment group (0.7 g/L; 95% CI, −6.6–8 g/L; p=0.84). The risk of anemia was lower in the treatment group (relative risk = 0.42; 95% CI, 0.22–0.79; p=0.003). Although majority of the patients had high baseline ferritin level, this study indicates that in our setting, ferritin may not be a reliable parameter to review the iron status, as it can be affected by chronic inflammation. Hence, the decision to start IV iron maintenance therapy in patients with hyperferritinemia should consider the patient’s clinical condition and morbidity. To conclude, the coadministration of IV iron maintenance therapy is beneficial for maintaining hemoglobin levels and preventing anemia in children with ESRD who are undergoing regular hemodialysis, have achieved the target hemoglobin levels, and have normal iron status.

Frequency of Vitamin D Deficiency and its association with serum PTH levels in End stage renal disease patients.

2020 ◽  
pp. 1-13
Author(s):  
Sidra Sattar ◽  
Farzana Adnan ◽  
Shahid Waheed
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Alkaline Phosphatase ◽  
Chi Square ◽  
Vitamin D Levels ◽  
Chi Square Test ◽  
Serum Pth ◽  
Stage Renal Disease ◽  
End Stage

Abstract Objective: To assess the frequency of Vitamin D Deficiency and its association with serum Parathormone (PTH) levels in End stage renal disease patients in our tertiary setup. Methods: This cross sectional study was conducted in the Department of Nephrology, Liaquat National Hospital from January to December 2016 and comprised of End stage renal disease on maintenance hemodialysis. Sample size of 113 at 8% prevalence was calculated inflated to 150. Participants were selected through purposive sampling technique. Numerical variables were expressed as mean +/- SD (standard deviation) while categorical variables were expressed as frequency and percentages. To determine association between Vitamin D and serum Parathormone (PTH) levels chi-square test was applied. Association of serum alkaline phosphatase levels with both Vitamin D levels and PTH levels was analyzed using chi-square test. SPSS 20 was used for data analysis. P-value <0.05 was taken as significant. Results: Of the 150 participants, 33 were drop outs, 63(53.8%) were males and 54(46.2%) were females. The overall mean age was 52.47+15.21. Of all, hypertension as a comorbidity was present in 64(54.7%), Diabetes mellitus was present in 8(6.8%) and cardiovascular disease in 7(6%). Among the biochemical markers, mean serum vitamin D levels were 18.6+13.6ng/ml, mean Serum PTH levels were 253.8+227.2pg/ml, mean serum alkaline phosphatase levels were 143.7+125.4µg/L, mean serum phosphorus levels were 4.81+3.46mg/dl and mean serum calcium levels were 21.41+114.4mg/dl. Among the study participants, 67(57.3%) were found to be Vitamin D deficient. Continuous...  

scholarly journals 25-Hydroxy Vitamin D Levels in Hemodialysis-Requiring End-Stage Renal Disease Patients

2008 ◽  
Vol 37 (10) ◽  
pp. 388-390 ◽  
Author(s):  
Guillermo Javier Rosa Diez ◽  
Juliana Fassi ◽  
Soledad Crucelequi ◽  
Hector Rivera Nuñez ◽  
Matias Trillini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Risk Estimation of Aortic Stiffness in Patients with End Stage Renal Disease on Maintenance Haemodialysis

2019 ◽  
Vol 9 (1) ◽  
pp. 59-62
Author(s):  
Muhammad Abdur Razzak ◽  
Debasish Kumar Saha ◽  
Muhammad Ehsan Jalil ◽  
Mohammad Omar Faruque Miah ◽  
Abu Noim Md Abdul Hai ◽  
...  
Keyword(s):  
Renal Disease ◽  
Serum Calcium ◽  
End Stage Renal Disease ◽  
Aortic Stiffness ◽  
Serum Phosphate ◽  
Serum Phosphate Level ◽  
Maintenance Haemodialysis ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background: The stiffness of the large elastic arteries increase the morbidity and mortality. The purpose of the present study was to estimate the risk of aortic stiffness among end stage renal disease patients on maintenance haemodialysis. Methods: This cross-sectional study was carried out in the Department of Nephrology at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka and National Institute of Cardiovascular Disease and Hospital (NICVD), Dhaka, Bangladesh from January 2013 to December 2014 for a period of two years. Chronic kidney disease in stage 5 [CKD-5(D)] patients older than 18 years on maintenance haemodialysis (MHD) for more than 3 months were designated as case group and age and sex matched non CKD patients were considered as control group. Serum calcium, serum albumin, serum phosphate and iPTH were estimated by semi-automated biochemistry analyzer from the Department of Biochemistry of NIKDU, Dhaka and NICVD, Dhaka. Plain Xray abdomen in lateral view was performed for all patients. Result: A total number of 100 patients were enrolled for this study of which 50 patients were in end stage renal disease (ESRD) group and the rest 50 patients were in non-CKD group. Mean (±SD) aortic stiffness index was significantly higher (P<0.001) among ESRD population (3.27±1.70) compared to non CKD group of population (2.00±0.73). Mean (±SD) serum calcium (corrected) level was significantly high (P<0.001) in ESRD patients (9.79±0.87) compared to non CKD group of population (9.13±0.70). Mean (±SD) serum phosphate level was significantly higher (P<0.001) in ESRD patients (5.71±0.96) compared to non CKD group of population (4.20±0.59). However, mean (±SD) iPTH level showed no significant difference between ESRD (25.33±51.98) and non CKD group of population (38.53±19.52). Conclusion: In conclusion, aortic stiffness is significantly higher among ESRD subjects. Birdem Med J 2019; 9(1): 59-62

Role of vitamin D in oxidative stress modulation in end‐stage renal disease patients: A double‐blind randomized clinical trial

2020 ◽  
Vol 24 (3) ◽  
pp. 367-373
Author(s):  
Leila Malekmakan ◽  
Zeinab Karimi ◽  
Afshin Mansourian ◽  
Maryam Pakfetrat ◽  
Jamshid Roozbeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Vitamin D ◽  
Renal Disease ◽  
Randomized Clinical Trial ◽  
End Stage Renal Disease ◽  
Double Blind ◽  
Stage Renal Disease ◽  
End Stage
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