scholarly journals Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Cahyani Gita Ambarsari ◽  
Partini Pudjiastuti Trihono ◽  
Agustina Kadaristiana ◽  
Dedi Rachmadi ◽  
Murti Andriastuti ◽  
...  
Keyword(s):  
Treatment Group ◽  
Renal Disease ◽  
Maintenance Therapy ◽  
End Stage Renal Disease ◽  
Comparison Group ◽  
Iron Status ◽  
Iv Iron ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

Iron deficiency anemia is common in children with end-stage renal disease (ESRD) on long-term hemodialysis receiving erythropoiesis-stimulating agents. One approach to maintain the iron profile and hemoglobin levels is maintenance therapy with regular low doses of intravenous (IV) iron after initial iron repletion therapy; however, evidence for the benefits of this approach is lacking. This study evaluated the effect of IV iron maintenance therapy on anemia in children on regular hemodialysis. This retrospective cohort study included 41 pediatric ESRD patients with normal hemoglobin and iron status who underwent regular hemodialysis at the Pediatric Dialysis Unit of Cipto Mangunkusumo Hospital, Indonesia, between January 2015 and April 2019. Among these, 21 received IV iron maintenance therapy with two doses of 2 mg/kg of IV iron sucrose every 2 weeks (the treatment group) and 20 did not (the comparison group). Changes in hemoglobin and transferrin saturation were assessed after 6 weeks of observation and compared between the two groups. There was a significant reduction in the mean hemoglobin level compared with the baseline level in the comparison group (21 g/L; 95% CI, 9.3–33 g/L; p=0.001) but not in the treatment group (0.7 g/L; 95% CI, −6.6–8 g/L; p=0.84). The risk of anemia was lower in the treatment group (relative risk = 0.42; 95% CI, 0.22–0.79; p=0.003). Although majority of the patients had high baseline ferritin level, this study indicates that in our setting, ferritin may not be a reliable parameter to review the iron status, as it can be affected by chronic inflammation. Hence, the decision to start IV iron maintenance therapy in patients with hyperferritinemia should consider the patient’s clinical condition and morbidity. To conclude, the coadministration of IV iron maintenance therapy is beneficial for maintaining hemoglobin levels and preventing anemia in children with ESRD who are undergoing regular hemodialysis, have achieved the target hemoglobin levels, and have normal iron status.

scholarly journals The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis

2021 ◽  
Vol 7 (1) ◽  
pp. e15-e15
Author(s):  
Essam Nour el Din Afifi ◽  
Ahmed Mohamed Tawfik ◽  
Essam Eldin Rashed Saeed Abdulkhalek ◽  
Lina Essam Khedr
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Serum Calcium ◽  
End Stage Renal Disease ◽  
Iron Status ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

Introduction: Anemia is a common complication in end-stage renal disease (ESRD) patients on regular hemodialysis (HD). There has been a lot of interest recently in the non-classical effects of 25(OH) vitamin D (calcidiol), including its association with erythropoiesis and anemia pathogenesis. Objectives: To study the relation between anemia and vitamin D status in patients on regular HD Results: This study is a cross-sectional study that included 90 patients on regular HD. Vitamin D status was classified into deficient (<20 ng/ mL), insufficient (20-30 ng/mL) and sufficient (>30 ng/mL). The level of vitamin D measured in the patients ranged between 3.5 to 66 ng/mL with median of 16.35 ng/mL. There were statistically significant positive correlations between vitamin D levels and the level of hemoglobin (P<0.001), serum calcium levels (P<0.001) and serum PO4 levels (P=0.023). Higher hemoglobin levels were statistically related to both higher vitamin D values (P<0.001) and higher serum calcium concentration P<0.001). Meanwhile, a significant negative correlation was found between hemoglobin levels and serum PTH values (P<0.001). Conclusion: There was a significant association between the status of vitamin D and the level of hemoglobin in dialysis population who were studied, independent from iron status. other associations with hemoglobin levels included PTH level and calcium.

Pilot Study Intra-Dialysis Yoga and Educational Comparison Group for Patients with End-Stage Renal Disease

2014 ◽  
Vol 20 (5) ◽  
pp. A51-A52
Author(s):  
Gurjeet Birdee ◽  
Russell Rothman ◽  
Amy Wheeler ◽  
Dolphi Wertenbaker ◽  
Chase Bossart ◽  
...  
Keyword(s):  
Pilot Study ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Comparison Group ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Assessment of cognitive functions and adaptive behavior in children with end-stage renal disease on regular hemodialysis

2020 ◽  
Vol 31 (2) ◽  
pp. 395
Author(s):  
MohamedAbdelaziz El-Gamasy ◽  
AzzaKamal Al Shahawy ◽  
MohammedAbd Elhakeem Seleem ◽  
Wegdan Mawlana ◽  
AmiraHassan El Sharkaway
Keyword(s):  
Renal Disease ◽  
Adaptive Behavior ◽  
Cognitive Functions ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

scholarly journals Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Violeta Dopsaj ◽  
Aleksandra Topić ◽  
Miljan Savković ◽  
Neda Milinković ◽  
Ivana Novaković ◽  
...  
Keyword(s):  
Renal Disease ◽  
Diagnostic Accuracy ◽  
End Stage Renal Disease ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Control Group ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background. Influence of TMPRSS6 A736V and HFE (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accuracy of the parameters to separate iron-deficiency anemia (IDA) from anemia of chronic disease. Materials and Methods. Iron status parameters and genetic analysis were performed in 126 ESRD patients and in 31 IDA patients as the control group. Results. ESRD patients had significantly higher ferritin and hepcidin-25 (<0.001) relative to IDA patients. Cut-off values with the best diagnostic accuracy were found for hepcidin ≥9.32 ng/mL, ferritin ≥48.2 μg/L, transferrin saturation ≥16.8%, and MCV ≥81 fL. Interaction between gender and HFE haplotypes for the hepcidin-25 and ferritin levels in ESRD patients (p=0.005, partial eta squared=0.09; p=0.027, partial eta squared=0.06, respectively) was found. Serum transferrin was influenced by the combined effect of gender and TMPRSS6 A736V polymorphism in ESRD patients (p=0.002, partial eta squared=0.07). Conclusion. Our findings could contribute to the further investigation of mechanisms involved in the pathophysiology and important gender-related involvement of the TMPRSS6 and HFE polymorphisms on anemia in ESRD patients.

scholarly journals The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140062 ◽  
Author(s):  
Juliana Casimiro de Almeida ◽  
Randall Lou-Meda ◽  
Marion Olbert ◽  
Markus Seifert ◽  
Günter Weiss ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Iron Status ◽  
Inflammatory Profile ◽  
Stage Renal Disease ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document