scholarly journals Non-invasive detection of arrhythmogenic foci of atria by using the cardioelectric field on the surface of the body during experimental pulmonary hypertension

2020 ◽  
Vol 27 (1) ◽  
pp. 63-69
Author(s):  
S. L. Smirnova ◽  
O. V. Suslonova ◽  
I. M. Roshchevskaya
Keyword(s):  
Pulmonary Hypertension ◽  
Body Surface ◽  
Pulmonary Veins ◽  
The Body ◽  
P Wave ◽  
Initial State ◽  
Excitation Wave ◽  
Non Invasive ◽  
Initial Excitation ◽  
Cardioelectric Field

Aim. The potential distribution of the cardioelectric field on the body surface during the initial atrial activity and the sequence of depolarization of the atrial subepicardium in rats with experimentally induced pulmonary hypertension were compared. This work is devoted to non-invasive detection of arrhythmogenic foci of atria by using the cardioelectric field on the body surface during experimental pulmonary hypertension.Materials and methods. The method of cardioelectrochronotopography has been used to study the electric field of the heart on the body surface and the sequence of propagation of the excitation wave along the atrial epicardium in rats with experimentally induced pulmonary hypertension caused by a single injection of monocrotaline (60 mg / kg, four weeks after drug administration).Results. Pulmonary hypertension causes the appearance of an additional focus of initial excitation in the area of the pulmonary vein lacunae, which leads to an increase in the heterogeneity of the propagation of the excitation wave along the atrial epicardium. The appearance of the additional excitation focus in the mouths of the pulmonary veins in the left atrium changes the picture of the sequence of depolarization of the atrial epicardium. The heterogeneity of the propagation of the excitation wave along the atrial epicardium is reflected in a different arrangement of zones of positive and negative cardioelectric potentials on the body surface before and during the P-wave in comparison with the initial state.Conclusion. Induced pulmonary hypertension contributes to the appearance of an additional focus of initial excitation in the area of the sleeves of the pulmonary veins of the left atrium in rats. This leads to an increase in the heterogeneity of the propagation of the excitation wave along the atrial epicardium. This is also reflected in the change in the arrangement of the zones of positive and negative cardioelectric potentials on the body surface before and during the P-wave in comparison with the initial state.

Abstract 14798: Right Atrial Function as Prognostic factor in Patients with Pulmonary Hypertension

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yuko Fukuda ◽  
Hidekazu Tanaka ◽  
Yoshiki Motoji ◽  
Keiko Ryo ◽  
Hiroki Matsuzoe ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Heart Catheterization ◽  
Adverse Outcomes ◽  
P Wave ◽  
Right Atrial ◽  
Heart Catheterization ◽  
Non Invasive ◽  
Chamber View ◽  
Point Set ◽  
Right Atrial Function

Background: The development of right ventricular (RV) dysfunction in patients with pulmonary hypertension (PH) has been associated with adverse outcomes. Right atrial (RA) function could be a prognostic factors as well as RV function, but non-invasive evaluation of RA function is limited. Our objective was thus to test the hypothesis that RA function was associated with hemodynamic parameters of RV performance in PH patients. Methods: Eighty PH patients with mean pulmonary artery pressure (PAP) of 40±11mmHg (all≥25mmHg) were recruited in this study. RA function was assessed by using two-dimensional speckle-tracking strain from RV-focused apical 4-chamber view. RA strain was calculated with the reference point set at the P wave, which enabled the recognition of peak negative (RAneg), positive strain (RAposi), and the sum of those values (RAtotal), corresponding to RA contractile, conduit, and reservoir function, respectively. All patients underwent right-heart catheterization for measurement of mean PAP and pulmonary vascular resistance (PVR). Results: RAneg (r=0.24 and p=0.03), RAposi (r=0.31 and p=0.01) and RAtotal (r=0.35 and p=0.001) were significantly correlated with mean PAP. In addition, RAposi (r=0.41 and p<0.001) and RAtotal (r=0.44 and p<0.001) were also correlated with PVR. Conclusions: Non-invasively assessed RA strains were associated with mean PAP and PVR. RA strain may be of a valuable additive factor for the management of PH patients, and thus have potential clinical applications.

Analysis of six cancer patients with persistent left superior vena cava identified during central venous access device placement via an intracavitary electrocardiogram

2021 ◽  
pp. 112972982110455
Author(s):  
Xinpeng Wang ◽  
Yong Yang ◽  
Jing Dong ◽  
Xiaozheng Wang ◽  
Yuanyuan Zheng ◽  
...  
Keyword(s):  
Body Surface ◽  
Superior Vena ◽  
Central Venous Access ◽  
Vena Cava ◽  
Venous Access ◽  
The Body ◽  
P Wave ◽  
P Waves ◽  
Venous Access Device ◽  
Surface Electrocardiogram

Persistent left superior vena cava (PLSVC) is a rare congenital anomaly. PLSVC can be associated with clinically significant atrial septal defect (ASD) or ventricular septal defect (VSD). It is usually asymptomatic and accidentally detected during invasive procedures or imaging examinations. However, whether central venous access device (CVAD) can be placed and used in patients with PLSVC is controversial. A total of six patients were diagnosed with PLSVC and confirmed by chest CT among 3391 cancer patients who underwent CVAD placement via intracavitary electrocardiogram (IC-EKG) at the Venous Access Center (VAC) from May 2019 to December 2020. The CVADs (peripherally inserted central catheter in four patients and Ports in two patients) of these six patients were left in PLSVC. We analyzed changes in the P-wave in the IC-EKG during CVAD placement and the characteristics of the body surface electrocardiogram in these patients and discussed the catheter tip position in PLSVC. All six patients showed negative P-waves in lead II via IC-EKG from the beginning of catheterization: four patients showed negative P-waves and two showed biphasic P-waves in the body surface electrocardiogram (lead III) before catheterization. CVAD function was normal and no obvious complications were observed during the treatment of these patients. The total retention time of CVADs was 1537 days. For patients with a negative P-wave in lead II via IC-EKG during catheterization, especially in those with a negative or biphasic P-wave in lead III of the body surface electrocardiogram, PLSVC should be considered. CVAD insertion in patients with type I PLSVC is safe under certain conditions, with the proper tip position in the middle to lower part of PLSVC.

scholarly journals Non-Invasive Assessment of Complexity of Atrial Fibrillation: Correlation with Contact Mapping and Impact of Ablation

2020 ◽  
Author(s):  
Miguel Rodrigo ◽  
Andreu M. Climent ◽  
Ismael Hernández-Romero ◽  
Alejandro Liberos ◽  
Tina Baykaner ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Surface ◽  
Response To Therapy ◽  
The Body ◽  
Surface Mapping ◽  
Electrocardiographic Imaging ◽  
Phase Singularity ◽  
Contact Mapping ◽  
Clinical Endpoints ◽  
Non Invasive

Background - It is difficult to non-invasively phenotype atrial fibrillation (AF) in a way that reflects clinical endpoints such as response to therapy. We set out to map electrical patterns of disorganization and regions of reentrant activity in AF from the body surface using electrocardiographic imaging (ECGI), calibrated to panoramic intracardiac recordings and referenced to AF termination by ablation. Methods - Bi-atrial intracardiac electrograms of 47 AF patients at ablation (30 persistent, 29 male, 63±9 years) were recorded with 64-pole basket catheters and simultaneous 57-lead body surface ECGs. Atrial epicardial electrical activity was reconstructed and organized sites were invasively and non-invasively tracked in 3D using phase singularity (PS). In a subset of 17 patients, sites of AF organization were targeted for ablation. Results - Body surface mapping showed greater AF organization near intracardially-detected drivers than elsewhere, both in PS density (2.3±2.1 vs 1.9±1.6, p=0.02) and number of drivers (3.2±2.3 vs 2.7±1.7, p=0.02). Complexity, defined as the number of stable AF reentrant sites, was concordant between non-invasive and invasive methods (r 2 =0.5, CC=0.71). In the subset receiving targeted ablation, AF complexity showed lower values in those in whom AF terminated than those in whom AF did not terminate (p<0.01). Conclusions - AF complexity tracked non-invasively correlates well with organized and disorganized regions detected by panoramic intracardiac mapping, and correlates with the acute outcome by ablation. This approach may assist in bedside monitoring of therapy or in improving the efficacy of ongoing ablation procedures.

scholarly journals A Fully-Coupled Electro-Mechanical Whole-Heart Computational Model: Influence of Cardiac Contraction on the ECG

2021 ◽  
Vol 12 ◽  
Author(s):  
Robin Moss ◽  
Eike Moritz Wülfers ◽  
Steffen Schuler ◽  
Axel Loewe ◽  
Gunnar Seemann
Keyword(s):  
Body Surface ◽  
In Silico ◽  
Computational Cost ◽  
Cardiac Motion ◽  
The Body ◽  
Cardiac Contraction ◽  
P Wave ◽  
Qrs Complex ◽  
T Wave ◽  
Whole Heart

The ECG is one of the most commonly used non-invasive tools to gain insights into the electrical functioning of the heart. It has been crucial as a foundation in the creation and validation of in silico models describing the underlying electrophysiological processes. However, so far, the contraction of the heart and its influences on the ECG have mainly been overlooked in in silico models. As the heart contracts and moves, so do the electrical sources within the heart responsible for the signal on the body surface, thus potentially altering the ECG. To illuminate these aspects, we developed a human 4-chamber electro-mechanically coupled whole heart in silico model and embedded it within a torso model. Our model faithfully reproduces measured 12-lead ECG traces, circulatory characteristics, as well as physiological ventricular rotation and atrioventricular valve plane displacement. We compare our dynamic model to three non-deforming ones in terms of standard clinically used ECG leads (Einthoven and Wilson) and body surface potential maps (BSPM). The non-deforming models consider the heart at its ventricular end-diastatic, end-diastolic and end-systolic states. The standard leads show negligible differences during P-Wave and QRS-Complex, yet during T-Wave the leads closest to the heart show prominent differences in amplitude. When looking at the BSPM, there are no notable differences during the P-Wave, but effects of cardiac motion can be observed already during the QRS-Complex, increasing further during the T-Wave. We conclude that for the modeling of activation (P-Wave/QRS-Complex), the associated effort of simulating a complete electro-mechanical approach is not worth the computational cost. But when looking at ventricular repolarization (T-Wave) in standard leads as well as BSPM, there are areas where the signal can be influenced by cardiac motion of the heart to an extent that should not be ignored.

A Non-Invasive Body Temperature Measurements in Cow using IR Thermometry

2021 ◽  
Author(s):  
S MURUGESWARI ◽  
Kalpana Murugan ◽  
R. Sundaraprem
Keyword(s):  
Body Temperature ◽  
Rectal Temperature ◽  
Body Surface ◽  
The Body ◽  
Temperature Measurements ◽  
Extreme Temperatures ◽  
Non Invasive ◽  
Surface Temperatures ◽  
Abdominal Region ◽  
Measuring Surface

Abstract This research deals with continuous surface body temperature measurements in cow using IR based thermometry. Body surface temperatures were estimated contactless utilizing recordings from an IR thermometry fixed at a specific region in the cow. The body surface temperatures were dissected reflectively at two regions: the rectal region (behind the tail) and abdominal region (nearer the stomach) in the cow. The traditional invasive rectal temperature filled in as a kind of perspective temperature and was estimated with a computerized thermometer at the comparing time point. An aggregate of ten cows (Redsindhi, HF cross, Kangayam ) was inspected. The normal most extreme temperatures of the territory of the rectal (mean ± SD: 38.69 ± 0.5°C) and the abdominal region (38.4 ± 0.51°C). The temperatures of these regions in the cow were 95% accurate than the traditional invasive rectal temperature measurements. Notwithstanding, the most extreme temperatures as estimated utilizing IR thermometry expanded with an expansion in cow rectal temperature. These temperature readings are then been communicate to the remote server for continuous monitoring of the condition of cows. This communication is carried out by using Bluetooth/Wifi medium. Since this framework comes out with a non-invasive fashion measuring surface body temperature, will be an alternate way of taking a reading of temperature rather than computing the internal body temperature in an invasive fashion. Subsequently, this IR thermometry shows potential as a marker for consistent temperature estimations in cows.

scholarly journals In search of markers of treatment failure and poor prognosis in IPAH – the value of mosaic lung attenuation pattern on thin-section CT scans

2010 ◽  
Vol 5 ◽  
Author(s):  
Monika Szturmowicz ◽  
Aneta Kacprzak ◽  
Barbara Burakowska ◽  
Marcin Kurzyna ◽  
Anna Fijałkowska ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Early Recognition ◽  
Pulmonary Veins ◽  
Connective Tissue Diseases ◽  
Non Invasive ◽  
Radiological Features ◽  
Lung Sample ◽  
Major Interest ◽  
Pulmonary Arterial ◽  
Idiopathic Pulmonary Hypertension

Despite the development of specific therapies for pulmonary arterial hypertension (PAH) some patients fail to respond to such treatment. One of the potential reasons for the unresponsiveness to targeted therapies may be the presence of fibrous occlusion of small pulmonary veins that accompanies pre-capillary arteriopathy. This type of pathologic change is called pulmonary veno-occlusive disease (PVOD). Underdiagnosed PVOD occurs probably in 5-10% of idiopathic pulmonary hypertension (IPAH) and in a substantial proportion of PAH related to connective tissue diseases (mainly in scleroderma). A definite diagnosis of PVOD requires histologi- cal examination of lung sample, but surgical lung biopsy in pulmonary hypertension is combined with high risk of bleeding. Thus major interest is focused on a non-invasive diagnostic approach enabling early recognition of PVOD and referral for lung transplantation. The present review is focused on the radiological features suggestive of PVOD-like vasculopathy in PAH.

The dynamics of the body surface cardioelectric field in one-day-old rats

2006 ◽  
Vol 410 (1) ◽  
pp. 370-372
Author(s):  
M. P. Roshchevsky ◽  
A. A. Yurkova ◽  
I. M. Roshchevskaya
Keyword(s):  
Body Surface ◽  
The Body ◽  
Cardioelectric Field ◽  
Old Rats

Abstract 16564: Location of Persistent Atrial Fibrillation Drivers Based on Body Surface Mapping: A Systematic Review and Metanalysis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Abdullah Sarkar ◽  
Mauricio Tellez ◽  
Shane Saifman ◽  
Daniel Weitz
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Body Surface ◽  
Pulmonary Veins ◽  
Final Analysis ◽  
Persistent Atrial Fibrillation ◽  
Body Surface Mapping ◽  
Surface Mapping ◽  
Non Invasive ◽  
Literature Searches

Introduction: Body Surface Mapping (BSM) is a non-invasive electrocardiogram-based mapping system that is used to identify localized drivers in patients with persistent Atrial Fibrillation (AF). Mapping of local drivers is becoming increasingly important in guiding treatment of atrial fibrillation but may not be readily available. We conducted a systematic review to determine the most prevalent atrial regions of AF driver activity identified with BSM. Methods: Electronic literature searches were performed across PubMed, Google Scholar, Cochrane, CINAHL, Web of science, EMBASE databases up to January 2019, for studies that utilized BSM to identify and report localized focal and rotor (reentrant) driver activity. Prevalence of drivers, as a percentage, were recorded for every region according to the Bordeaux Biatrial Schema. Random-effects model was used to calculate weighted averages with the corresponding 95% confidence interval (CI). Results: Total of 468 unique studies were identified and reviewed. 4 prospective cohort studies were included in the final analysis—of which 3 were single-center and 1 was multi-centered; totaling 336 patients. The mean age was 62.8 (±5.41) and 73% were males. The three most prevalent regions with persistent AF foci activity were region 1 (left pulmonary veins and left appendage): 59% (CI 48-71), followed by region 4 (upper half of right atrium and appendage): 31% (CI 12-54), and region 2 (right pulmonary veins and posterior interatrial groove): 19% (CI 7-34). The three most prevalent regions of persistent AF rotor activity were region 3 (inferior and posterior left atrium): 71% (CI 32-98), region 1: 70% (CI 21-100), and region 2: 70% (CI 25-99). Conclusion: In patients with persistent AF, majority of localized drivers seem to originate from specific atrial regions based on BSM.

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