scholarly journals Structural changes of the tendon in experimental tendinopathy and administration of autologous platelet-rich plasma

2021 ◽  
Vol 6 (3) ◽  
pp. 56-62
Author(s):  
Dmitrii А. Malanin ◽  
Lyudmila N. Rogova ◽  
Natalya V. Grigorieva ◽  
Mariya R. Ekova ◽  
Victoriya N. Povetkina ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Inflammatory Process ◽  
Structural Changes ◽  
Soft Tissues ◽  
Platelet Rich Plasma ◽  
Collagen Matrix ◽  
Calcaneal Tendon ◽  
Sequential Combination ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Objectives assessment of structural changes in the calcaneal tendon tissue in experimental tendinopathy under autologous platelet-rich plasma. Material and methods. Twenty mature Wistar rats, selected for the study, were divided into 5 groups. Rats of all groups received intra- and peritendinous injections of 0.5 ml of 10% sterile talc suspension to provide the experimental modeling of tendinopathy of the calcaneal tendon. Then the tendinopathy area was treated by injections of autologous platelet-rich plasma (PRP), a hyaluronic acid preparation "Rusvisk" (Rusvisk, Russia) and their sequential combination. The results were evaluated after 10 weeks in the autopsy preparations using a light microscopy method and morphometry. Results. The histological signs characteristic of tendinopathy were revealed, such as the disorganization of collagen structures, mucoid and lipoid degeneration, neovascularization, lymphoid and histiocytic infiltration. The injection of PRP, hyaluronic acid, or their sequential combination in the area of simulated tendinopathy led to changes in the histological presentation of the tissue. As a result, the collagen matrix had less signs of disorganization and less pronounced degenerative changes, as well as manifestations of the inflammatory process in the peritenon and the soft tissues surrounding the tendon, in comparison with the histological profile, which was observed in micropreparations in animals with tendinopathy who had no treatment. Conclusion. The introduction of PRP into the area of the calcaneal tendon has reduced the manifestations of the inflammatory process, disorganization of the collagen matrix, promoted the enhancement of collagen synthesis by cells and, ultimately, the processes of tissue remodeling.

Comparative analysis of the effectiveness of surgical techniques for the treatment of Miller Class I gingival recessions

2021 ◽  
Vol 26 (2) ◽  
pp. 150-157
Author(s):  
R. R. Farkhshatova ◽  
L. P. Gerasimova ◽  
I. T. Yunusov
Keyword(s):  
Connective Tissue ◽  
Soft Tissues ◽  
Platelet Rich Plasma ◽  
Class I ◽  
Study Group ◽  
Connective Tissue Graft ◽  
Group I ◽  
Autologous Platelet Rich Plasma ◽  
Group Ii ◽  
Autologous Platelet

Relevance. It is currently relevant to study and compare the effectiveness of the autologous connective tissue grafts and the combination of collagen-based and autologous platelet-rich plasma in the surgical treatment of Miller Class I gingival recessions.Materials and methods. We examined and treated 48 (20 male (41.67%) and 28 female (58.33%)) patients aged from 25 to 40 years with Miller Class I gingival recessions. All gingival recessions were treated surgically using a modified twolayer tunnel technique. The patients were divided into two groups according to the graft type. Group I (24 patients (50%) had a connective tissue graft from the hard palate. Group II (24 patients (50%) used the combination of the autologous platelet-rich plasma and 3D collagen matrix Fibromatrix for the regeneration of oral soft tissues. We removed the sutures on the 14th day. The patients were followed up on the 7th and 14th days and in 1.3 months.Results. 48 Miller Class I gingival recessions were treated between 2018 and 2020. The depth of gingival recessions averaged 3.5 ± 1.13 mm before treatment. The level of the attached keratinized gingiva regarding the cementoenamel junction significantly (p < 0.001) improved in both groups after the surgery. The width and thickness of the keratinized gingiva best increased in group II. The mean effectiveness of gingival recession treatment was 84% in study group I and 96% – in study group II. Pain syndrome, fibrinous plaque and soft tissue edema were insignificant in group II.Conclusion. The combination of the autologous platelet-rich plasma and Fibromatrix, collagen 3D matrix, for the regeneration of the oral soft tissues is a more effective technique for the treatment of Miller Class I gingival recessions. This technique has several advantages. It is minimally invasive, less painful, soft tissue postoperative swelling is less and the received volume of the attached keratinized gums is larger than with a connective tissue graft. 

scholarly journals Autologous platelet-rich plasma combined with hyaluronic acid is a new method of minimally invasive treatment of stress urinary incontinence in women

2018 ◽  
pp. 16-20
Author(s):  
I. A. Apolikhina ◽  
A. V. Sokolova ◽  
A. S. Saidova ◽  
E. A. Gorbunova
Keyword(s):  
Urinary Incontinence ◽  
Hyaluronic Acid ◽  
Stress Urinary Incontinence ◽  
Platelet Rich Plasma ◽  
Physiological Mechanism ◽  
Common Disease ◽  
Invasive Treatment ◽  
Autologous Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Stress urinary incontinence (SUI) is a common disease. It is 2 times more common among women than in men. The causes of SUI are the insufficiency of the closing function of the sphincter of the bladder and/or hypermobility of the urethra. For this reason, methods aimed at improving the closing function of the urethra, i.e., the use of volume-forming agents are justified for the treatment of this disease. Side effects and time-limited relief of symptoms of urinary incontinence after the application of volumeforming agents, or at the other hand complications after surgery lead to the search for alternative treatments that can restore the natural physiological mechanism of urinary retention. This study demonstrates that administration of platelet-rich autologous plasma in combination with hyaluronic acid in the periurethral region is a safe and effective method of treatment of SUI in women.

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