scholarly journals The Dose-Dependent Effects of Ketoprofen on Dynamic Pain after Open Heart Surgery

2017 ◽  
Vol 6 (20;6) ◽  
pp. 509-520
Author(s):  
Christian Dualé
Keyword(s):  
Postoperative Pain ◽  
Heart Surgery ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Pilot Trial ◽  
Open Heart Surgery ◽  
University Hospital ◽  
Low Doses ◽  
Open Heart ◽  
Double Blind

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce postoperative pain, in both static (i.e., at rest) and dynamic contexts (e.g., during coughing or mobilization), and reduced doses could improve their efficacy/tolerance balance. Objectives: To test this hypothesis of efficacy after open heart surgery, in which NSAIDs are poorly used, particularly for safety concerns. Study Design: Randomized, double-blind trial. Setting: Single-center, French university hospital. Methods: Patients. One hundred patients at low risk of postoperative complications undergoing scheduled open heart surgery (97 analyzed). Intervention. We tested intravenous ketoprofen, at a dose of 0.5 mg/kg-1 every 6 hours during the 48 hours following the end of sedation, after surgery. This standard protocol was compared to a similar one in which half doses were administered, to one with quarter doses, as well as to a placebo group. Analgesia was supplemented by acetaminophen plus self- and nurse-administered intravenous morphine. Measurement. The primary outcome was the intensity of dynamic pain, assessed over 48 hours on an 11-point numerical rating scale (NRS). Results: Only the full-dose ketoprofen group showed reduced dynamic and static postoperative pain vs. placebo (P < 0.00001 for both). The evolution of dynamic pain suggested a delayed and therefore non-significant effect with the low doses. Ketoprofen did not affect either the postoperative morphine consumption or the tolerance outcomes, such as the volumes of chest tube drainage and the renal function. Limitations: This pilot trial was undersized to test major tolerance outcomes. Conclusions: Although we failed to demonstrate any analgesic effects with low doses of ketoprofen, we confirmed the good efficacy/tolerance balance with this propionic NSAID of intermediate COX2 -selectivity. Lower doses of NSAIDs, potentiated by a loading dose, should be tested in the future. IRB approval: CPP Sud-Est VI (Clermont-Ferrand, France), on 12/23/2013. Clinical trial registry: EudraCT (2013-003878-27); ClinicalTrials.gov (NCT02180087)

scholarly journals Effect of Music on Postoperative Pain in Patients Under Open Heart Surgery

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Neda Mirbagher Ajorpaz ◽  
Abouzar Mohammadi ◽  
Hamed Najaran ◽  
Shala Khazaei
Keyword(s):  
Postoperative Pain ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

The effects of remifentanil and fentanyl on postoperative pain and recovery in fast-track open heart surgery

2004 ◽  
Vol 21 (Supplement 33) ◽  
pp. 23-24
Author(s):  
S. Turan ◽  
Ü. Karadeniz ◽  
Ö. B. Soyal ◽  
Ö. Erdemli
Keyword(s):  
Postoperative Pain ◽  
Fast Track ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

scholarly journals Frequency of Renal Dysfunction and its effects on outcomes after open heart surgery

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Taimur Asif Ali ◽  
Khuzaima Tariq ◽  
Areej Salim ◽  
Saulat Fatimi
Keyword(s):  
Renal Replacement Therapy ◽  
Renal Dysfunction ◽  
Replacement Therapy ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
University Hospital ◽  
P Value ◽  
Open Heart ◽  
Creative Commons ◽  
Postoperative Serum

Objectives: In this study we determined the frequency of renal dysfunction and its outcomes in terms of morbidity and mortality in patients who underwent open heart surgery at the Aga Khan University Hospital, Karachi, Pakistan. Methods: A total of 175 patients aged between 15-80 years having open heart Surgery(OHS) were included. Preoperative and postoperative serum creatinine (SCr) was noted and the glomerular filtration rate (GFR) calculated by Cockcroft-Gault equation. Their hospital course was charted and followed-up for 30-day. Results: The mean age and mean BMI were 58.1±12.6 years and 26.4±4.3 kg/m2 respectively. Females were 18.3%, out of which 51.4% hypertensive, 46.9% diabetics, 45.1% had dyslipidemia, 2.9% had preoperative renal dysfunction and 40% had moderate ejection fraction. On follow up, 30.3% developed postoperative renal dysfunction within 30-days after OHS with mean SCr and GFR as 1.6±0.7 and 56.9±24.5, respectively. In RD group more patients showed positive outcomes i.e. prolonged inotropic requirement (75.5% vs. 18%, p-value <0.005), diuretic infusion usage (47.2% vs. 3.3%, p-value <0.005), dialysis/renal replacement therapy (17% vs. 0%, p-value <0.005), requirement for prolonged ventilation (35.8% vs. 6.6%, p-value <0.005), prolonged ICU and hospital stay (15.4% vs. 1.6%, p-value <0.005 and 41.5% vs. 17.2%, p-value <0.005), sepsis (20.8% vs. 1.6%, p-value <0.005) and death (9.4% vs. 2.5%, p-value 0.05). Conclusion: Timely recognition of renal dysfunction, early renal replacement therapy, diuretics or dialysis and proper nutritional and inotropic support to maintain adequate hemostasis shows survival benefits. doi: https://doi.org/10.12669/pjms.37.7.3865 How to cite this:Ali TA, Tariq K, Salim A, Fatimi S. Frequency of Renal Dysfunction and its effects on outcomes after open heart surgery. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.3865 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effect of Home-Based Cardiac Rehabilitation Program on Exercise Capacity in Open Heart Surgery Patients at Naresuan University Hospital

2017 ◽  
Vol 35 (4) ◽  
pp. 285
Author(s):  
Phavinee Paorod ◽  
Weerapong Chidnok ◽  
Jarun Sayasathid
Keyword(s):  
Cardiac Rehabilitation ◽  
Exercise Capacity ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Rehabilitation Program ◽  
University Hospital ◽  
Open Heart ◽  
Cardiac Rehabilitation Program ◽  
Home Based

Objective: To investigate the effects of home-based cardiac rehabilitation program on exercise capacity using the six-minute walk test (6-MWT) in open heart surgery patients, Naresuan University Hospital.Material and Method: In a quasi-experimental study design, seventy patients who were diagnosed with heart diseases and received open heart surgery at Cardiac Center, Naresuan University Hospital were enrolled and collected data from October 2015 - September 2016 (n=70). The patients completed 8-12 weeks home-based cardiac rehabilitation program. The patients were performed the 6-MWT before hospital discharge, the first and second follow up time point. Data were expressed as average mean and chi-square test were used to determine the relationships among outcome parameters.Results: There was a significant within-group in 6-MWT distance after completed home-based cardiac rehabilitation program (377.0±69.0 meters) compared to before hospital discharge (209.0±62.0 meters) and the first follow up time point (4-8 weeks) (306.0±88.0 meters) (p-value<0.050).Conclusion: The 8-12 weeks home-based cardiac rehabilitation program exhibited significant positive effects on exercise capacity in open heart surgery patients, Naresuan University Hospital.

scholarly journals Double-blind comparison of cefazolin and cephalothin in open-heart surgery

1978 ◽  
Vol 76 (4) ◽  
pp. 506-509 ◽  
Author(s):  
P.M. Kini ◽  
Javier Fernandez ◽  
Ramon S. Causay ◽  
Gerald M. Lemole
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Double Blind ◽  
Blind Comparison

Open Heart Surgery in National University Hospital(1959-1993)

1994 ◽  
Vol 24 (6) ◽  
pp. 753
Author(s):  
Kyung Phill Suh ◽  
Joon Ryang Rho ◽  
Yong Jin Kim ◽  
Hyuk Ahn ◽  
Yung Kyoon Lee
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
University Hospital ◽  
Open Heart ◽  
National University
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