scholarly journals HEPATIC STEATOSIS IN LIVER DONORS: A COMPARATIVE STUDY BETWEEN COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING – PROTON DENSITY FAT FRACTION BASED HEPATIC FAT GRADINGS.

2021 ◽  
pp. 1-3
Author(s):  
Anandhu Krishnan G ◽  
Rajsekar C S ◽  
Srikanth Moorthy ◽  
Rubalakshmi S ◽  
Saitheja Paidipelly ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Therapeutic Option ◽  
Proton Density ◽  
Fat Percentage ◽  
Mean Values ◽  
Donor Liver Transplantation ◽  
Significant Difference ◽  
Hepatic Fat ◽  
Fat Fraction ◽  
Liver Donors

Background: Living donor liver transplantation is being used as the main therapeutic option in the management of end-stage liver disease patients especially since there is inadequate availability of deceased donors. Degree of hepatic steatosis in prospective liver donors can affect the tissue regeneration in both donors and recipients and as well as the success of the surgery. MRI-PDFF is the best modality for the non-invasive assessment of hepatic steatosis in the literature, however CT is more commonly employed for the same. The qualitative data of hepatic fat using CT based methods are compared with MRI-PDFF based gradings. Methods: The study included 35 prospective liver donors assessed between August 2018 to August 2020. All patients were evaluated with MRI- PDFF (IDEAL) sequence and fat fraction maps were obtained. The mean fat percentage was calculated and grading of hepatic steatosis was done. In plain MDCT 0.5 mm CT cuts, mean values of hepatic CT attenuation values corresponding MRI fat fraction maps were taken. Grading of the hepatic steatosis based on CT parameters like liver-spleen attenuation ratio (L/S) and liver-spleen attenuation difference(L-S) was done. Both CT and MRI based gradings were assessed for any statistical difference. Results: The categorical data (grading) based on MR derived fat fraction and both CT based parameters mentioned above were evaluated with Chi Square test that showed no significant difference (p = 0.083). Conclusion: Grading of hepatic steatosis using CT based parameters shows no statistically significant difference with MRI-PDFF based grading.

scholarly journals Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women

2015 ◽  
Vol 25 (10) ◽  
pp. 2921-2930 ◽  
Author(s):  
Jennifer L. Rehm ◽  
Peter M. Wolfgram ◽  
Diego Hernando ◽  
Jens C. Eickhoff ◽  
David B. Allen ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Adolescent Girls ◽  
Young Women ◽  
Proton Density ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

scholarly journals Reliability of ultrasound hepatorenal index and magnetic resonance imaging proton density fat fraction techniques in the diagnosis of hepatic steatosis, with magnetic resonance spectroscopy as the reference standard

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255768
Author(s):  
Bien Van Tran ◽  
Kouichi Ujita ◽  
Ayako Taketomi-Takahashi ◽  
Hiromi Hirasawa ◽  
Takayuki Suto ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Hepatic Steatosis ◽  
Gold Standard ◽  
Correlation Coefficients ◽  
Proton Density ◽  
Resonance Spectroscopy ◽  
Reference Standard ◽  
Resonance Imaging ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

Purpose To evaluate the reliability of ultrasound hepatorenal index (US-HRI) and magnetic resonance imaging proton density fat fraction (MRI-PDFF) techniques in the diagnosis of hepatic steatosis, with magnetic resonance spectroscopy proton density fat fraction (MRS-PDFF) as the reference standard. Materials and methods Fifty-two adult volunteers (30 men, 22 women; age, 31.5 ± 6.5 years) who had no history of kidney disease or viral/alcoholic hepatitis were recruited to undergo abdominal US, MRI, and MRS examinations. US-HRI was calculated from the average of three pairs of regions of interest (ROIs) measurements placed in the liver parenchyma and right renal cortex. On MRI, the six-point Dixon technique was employed for calculating proton density fat fraction (MRI-PDFF). An MRS sequence with a typical voxel size of 27 ml was chosen to estimate MRS-PDFF as the gold standard. The data were evaluated using Pearson’s correlation coefficient and receiver operating characteristic (ROC) curves. Results The Pearson correlation coefficients of US-HRI and MRI-PDFF with MRS-PDFF were 0.38 (p = 0.005) and 0.95 (p<0.001), respectively. If MRS-PDFF ≥5.56% was defined as the gold standard of fatty liver disease, the areas under the curve (AUCs), cut-off values, sensitivities and specificities of US-HRI and MRI-PDFF were 0.74, 1.54, 50%, 91.7% and 0.99, 2.75%, 100%, 88.9%, respectively. The intraclass correlation coefficients (ICCs) of US-HRI and MRI-PDFF were 0.70 and 0.85. Conclusion MRI-PDFF was more reliable than US-HRI in diagnosing hepatic steatosis.

Hepatic Steatosis: Quantification by Proton Density Fat Fraction with MR Imaging versus Liver Biopsy

Radiology ◽  
2013 ◽  
Vol 267 (3) ◽  
pp. 767-775 ◽  
Author(s):  
Ilkay S. Idilman ◽  
Hatice Aniktar ◽  
Ramazan Idilman ◽  
Gokhan Kabacam ◽  
Berna Savas ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Mr Imaging ◽  
Hepatic Steatosis ◽  
Proton Density ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

scholarly journals Cross-sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis

2017 ◽  
Vol 47 (2) ◽  
pp. 418-424 ◽  
Author(s):  
Adrija Mamidipalli ◽  
Gavin Hamilton ◽  
Paul Manning ◽  
Cheng William Hong ◽  
Charlie C. Park ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Proton Density ◽  
Cross Sectional ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

scholarly journals MR Spectroscopy–derived Proton Density Fat Fraction Is Superior to Controlled Attenuation Parameter for Detecting and Grading Hepatic Steatosis

Radiology ◽  
2018 ◽  
Vol 286 (2) ◽  
pp. 547-556 ◽  
Author(s):  
Jurgen Henk Runge ◽  
Loek Pieter Smits ◽  
Joanne Verheij ◽  
Annekatrien Depla ◽  
Sjoerd Douwe Kuiken ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Mr Spectroscopy ◽  
Proton Density ◽  
Controlled Attenuation Parameter ◽  
Proton Density Fat Fraction ◽  
Attenuation Parameter ◽  
Fat Fraction

scholarly journals Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Francesco Paparo ◽  
Giovanni Cenderello ◽  
Matteo Revelli ◽  
Lorenzo Bacigalupo ◽  
Mariangela Rutigliani ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Diagnostic Accuracy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Liver Stiffness ◽  
Diagnostic Value ◽  
Proton Density ◽  
Time Interval ◽  
Fat Fraction

Objective.To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard.Methods.Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days.Results.Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18–81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r=0.754, 95% CI 0.637 to 0.836,P<0.0001), and the correlation was influenced by neither the liver stiffness nor the T2*decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P<0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) forS≥1and 0.929 (95% CI 0.847 to 0.975) forS=2.Conclusions.Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

scholarly journals Comparison of sonographic hepatorenal ratio and the degree of hepatic steatosis in magnetic resonance imaging-proton density fat fraction

2020 ◽  
Vol 20 (82) ◽  
pp. 169-175
Author(s):  
Natthaporn Tanpowpong ◽  
◽  
Sineenart Panichyawat ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hepatic Steatosis ◽  
Cutoff Point ◽  
Proton Density ◽  
Resonance Imaging ◽  
Proton Density Fat Fraction ◽  
Abdominal Magnetic Resonance Imaging ◽  
Fat Fraction ◽  
The Right

Objectives: Conventional ultrasonography can provide only semi-quantitative assessment of hepatic steatosis. The aim of this study was to assess sonographic hepatorenal ratio to quantify the severity of fatty liver. Methods: We performed a retrospective analysis of 179 patients with various liver diseases who underwent abdominal magnetic resonance imaging and ultrasonography on the same day. The hepatorenal ratio was calculated by the ratio between the mean echo intensity in regions of interests of the liver and regions of interests of the right renal cortex. Magnetic resonance imaging-proton density fat fraction was used as standard reference for steatosis grading. The effect of fibrosis measured by magnetic resonance elastography on the degree of correlation was also assessed. Results: The hepatorenal ratio was highly correlated with magnetic resonance imaging-proton density fat fraction (Spearman’s coefficient = 0.83) (p <0.001). High correlation of hepatorenal ratio with magnetic resonance imaging-proton density fat fraction was observed in patients with less than stage 2 fibrosis (p <0.001), whereas moderate correlation of hepatorenal ratio with magnetic resonance imaging-proton density fat fraction was found in patients with ≥ stage 2 fibrosis or higher (p <0.001). The hepatorenal ratio cutoff point for prediction of grade 1 hepatic steatosis was 1.18 with sensitivity of 90.0% and specificity of 80.0%. The hepatorenal ratio cutoff point for prediction of grade 2 and grade 3 hepatic steatosis was 1.55 and 1.60, respectively, with sensitivity greater than 90% and specificity greater than 80%. Conclusions: The hepatorenal ratio could become an effective quantitative tool for hepatic steatosis alternative to magnetic resonance imaging-proton density fat fraction. Application should be careful in the group of patients with stage 2 liver fibrosis or higher.

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