ROLE OF HS CRP AND LIPID ABNORMALITIES AS RISK FACTOR IN CORONARY ARTERY DISEASE

2021 ◽  
pp. 37-39
Author(s):  
Dipankar Kundu ◽  
Aniket Paul ◽  
Sourish Ghosh
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Study Results ◽  
Hs Crp ◽  
Artery Disease ◽  
Lipid Abnormalities

BACKGROUND: In recent years, data suggesting that certain markers of inammation play a key role in the development and progression of atherosclerosis. hsCRP has shown promising results as a predictor of Coronary Artery Disease(CAD). OBJECTIVES: To evaluate the signicance of CRP as one of the most reliable markers in coronary artery disease and to study the role of lipid abnormalities as a risk factor in coronary artery disease. MATERIALS AND METHODS: Study was conducted at MedicalCollege, Kolkata.30 cases and 30 controls were studied. Angiographically proven cases of CAD aged between 40- 60 years of both sexes were included in the study as cases. Age and sex matched individuals without CAD weSre considered as cases. Patients with recent myocardial infarction, unstable angina (<6months).and with other inammatory conditions were excluded from the study. RESULTS: hsCRP was signicantly higher in CAD cases2.0±1.4 compared with controls0.8±0.7 and this was statistically signicant <0.001.Lipid parameters such as Total Cholesteol,Triglycerides and Low density lipoprotein were elevated in cases compared with controls and was found to be statistically signicant. Blood glucose parameters both in fasting and post-prandial conditions were found to be elevated in cases compared with controls. CONCLUSION: The study thus suggests that hsCRP level appears to be a dependable marker of CAD.Thus, hsCRP can be used as a sensitive predictor of CAD.

2.P.182 Low density lipoprotein-associated phospholipase A2 (LDL-PLA2) as a risk factor for coronary artery disease

1997 ◽  
Vol 134 (1-2) ◽  
pp. 154
Author(s):  
M.J. Caslake ◽  
C. McPhee ◽  
K.E. Suckling ◽  
S. Holmes ◽  
P. Chamberlain ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Phospholipase A2 ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Artery Disease

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

2020 ◽  
Vol 96 (1141) ◽  
pp. 666-673
Author(s):  
Zhan Lu ◽  
Zhi Luo ◽  
Aimei Jia ◽  
Irfan Muhammad ◽  
Wei Zeng ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Stenosis ◽  
Low Density Lipoprotein ◽  
Coronary Vessels ◽  
Density Lipoprotein ◽  
Gensini Score ◽  
Risk Alleles ◽  
Hs Crp ◽  
Artery Disease

BackgroundThe relationships between the rs1800976, rs4149313 and rs2230806 polymorphisms in ATP binding cassette protein A1 and severity of coronary artery disease (CAD) remain unclear.MethodsFour hundred and forty-two patients with CAD and 217 CAD-free subjects were enrolled in this study. The rs1800976, rs4149313 and rs2230806 polymorphisms were genotyped by PCR-RFLP. Severity of CAD was evaluated by Gensini score system, number of stenotic coronary vessels and extent of coronary stenosis.ResultsC allele of the rs1800976 polymorphism, G allele of the rs4149313 polymorphism and A allele of the rs2230806 polymorphism were found to be risk alleles for CAD (p<0.05 for all). In patients with CAD, C allele of the rs1800976 polymorphism was associated with high levels of hypersensitive C reactive protein (hs-CRP) and cystatin c (CysC), and its frequency increased with percentiles of Gensini score, number of stenotic coronary vessels and extent of coronary stenosis (p<0.05 for all). The subjects with GA genotype of the rs4149313 polymorphism had higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and hs-CRP than those with AA genotype (p<0.05 for all). The subjects with AA genotype of the rs2230806 polymorphism had higher levels of TC, LDL-C and uric acid than those with GA genotype (p<0.05 for all). No associations between the rs4149313 or rs2230806 polymorphism and severity of CAD were detected.ConclusionsThe rs1800976 polymorphism is significantly associated with the occurrence and severity of CAD, which is possibly mediated by hs-CRP and CysC.

scholarly journals Role of the APOB Gene Polymorphism (c.12669G>A, p. Gln4154Lys) in Coronary Artery Disease in the Indian Punjabi Population

2011 ◽  
Vol 14 (2) ◽  
pp. 35-40 ◽  
Author(s):  
R Sharma ◽  
M Mahajan ◽  
B Singh ◽  
G Singh ◽  
P Singh
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Concentration ◽  
Artery Disease

Role of theAPOBGene Polymorphism (c.12669G>A, p. Gln4154Lys) in Coronary Artery Disease in the Indian Punjabi PopulationHigh concentration of apolipoprotein B (apoB) is a risk factor for coronary artery disease (CAD). The association of theAPOBgene polymorphism c.12669G>A, p. Gln4154Lys with the risk of CAD varies considerably in different populations. The present study represents the first investigation regarding the role of thisAPOBgene polymorphism with CAD in the Indian Punjabi population. We have studied theAPOBgene polymorphism c.12669G>A, p. Gln4154Lys and its relationship with lipid, apoB, low-density lipoprotein (LDL) heterogeneity and oxidation in subjects suffering from CAD. The study was conducted on 87 patients with CAD; 75 healthy subjects served as controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the DNA polymorphism in theAPOBgene. Frequency of R-(mutant) allele was significantly high (p<0.05) in CAD patients when compared to controls. Variations in serum lipid levels in the R+R+ and R+R-APOBgenotypes were insignificant (p>0.05). However, serum apoB levels were significantly raised (p<0.05) in CAD patients with the R+R- genotype as compared to those with the R+R+APOBgenotype. Coronary artery disease patients had raised significantly raised (p<0.01) Log triglyceride/high density lipoprotein-cholesterol (HDL-C) ratio, apoB carbonyl content and increased malondialdehyde-low density lipoprotein (MDA-LDL levels, irrespective ofAPOBgenotype as compared to controls. Carriers of the R- allele are at higher risk of CAD, probably because of elevated serum apoB levels in the Indian Punjabi population. Overall, it may be concluded that the R- allele might be associated with increased susceptibility towards CAD development in the Indian Punjabi population, and one of the linking factor is the elevation in serum apoB levels. However, this association needs further evaluation in a larger population. Secondly, the robust mechanism behind the positive association of the R- allele with raised serum apoB levels needs to be explored, which might be helpful in the strengthening the observed results.

scholarly journals High-Density vs Low-Density Lipoprotein Cholesterol as the Risk Factor for Coronary Artery Disease and Stroke in Old Age

2003 ◽  
Vol 163 (13) ◽  
pp. 1549 ◽  
Author(s):  
Annelies W. E. Weverling-Rijnsburger ◽  
Iris J. A. M. Jonkers ◽  
Eric van Exel ◽  
Jacobijn Gussekloo ◽  
Rudi G. J. Westendorp
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Old Age ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Artery Disease
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