scholarly journals STUDY OF CLINICOPATHOLOGICAL SPECTRUM OF OVARIAN NEOPLASMS WITH SPECIAL REFERENCE TO EXPRESSION OF ER AND PR IN MALIGNANT LESIONS

2020 ◽  
pp. 67-69
Author(s):  
Sujata Ganguli ◽  
Keya Basu ◽  
Ranjana Bandyopadhyay
Keyword(s):  
Germ Cell ◽  
Special Reference ◽  
Reproductive System ◽  
Ovarian Neoplasms ◽  
Germ Cell Tumours ◽  
Female Reproductive System ◽  
Gynaecological Malignancy ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Malignant Lesions

Ovarian carcinoma is the second most common carcinoma of the female reproductive system .It is the leading cause of death from gynaecological malignancy .The purpose of this study is to observe the clinicopathological spectrum of ovarian neoplasms with the expression of ER and PR in the different malignant lesions .A total of 156 cases of ovarian tumours were included in this study, and surface epithelial tumours were found to be the commonest neoplasm followed by germ cell tumours. Expression of ER and PR was found to be highest in Serous and Endometrioid tumours. PR Negative cases showed a higher grade and stage.

scholarly journals Clinicopathological study of benign and malignant ovarian tumours and the role of HER2/neu and ER expression in these tumours

2019 ◽  
Vol 7 (6) ◽  
pp. 2132
Author(s):  
Nidhi Verma ◽  
Kriti Grover ◽  
S. P. Sharma ◽  
Priya Gupta ◽  
Preeti Singh ◽  
...  
Keyword(s):  
Germ Cell ◽  
Mature Teratoma ◽  
Germ Cell Tumours ◽  
Malignant Tumours ◽  
Positive Expression ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Benign Tumours ◽  
Er Expression

Background: Ovarian cancers represent the 6th most common cancer among females and are the most common cause of death from gynaecological cancers in the world. The aim is to do clinicopathologic study of ovarian tumours along with evaluation of the expression of estrogen receptor (ER) and human epidermal growth factor receptor (HER2/neu).Methods: A total of 85 cases of ovarian tumors were studied and immunohistochemistry was performed with specific antibodies against ER and HER2/neu as per standard protocol.Results: In present study, surface epithelial tumours were the commonest type comprising 64 cases (75.2%), followed by Germ cell tumours, 17cases (20%) and sex cord stromal tumours, 04 cases (4.8%).Among the surface epithelial tumours , ER‑positive cases were higher in malignant (71.4%) tumours as compared to borderline tumours (33.3%) and benign tumours (7.7%) while Her2/neu positive cases were higher in borderline (66.7%) tumours as compared to malignant tumours (42.9%) and benign tumours (15.3%).Among the germ cell tumours, ER expression was positive in 62.5% cases of mature teratoma while HER2/neu expression was positive in only 12.5% cases of mature teratoma. None of the sex cord stromal tumours showed positive expression of ER and HER2/neu.Conclusions: Positive expression of estrogen receptors is seen predominantly in surface epithelial malignancies and in mature teratoma. It proves the mitogenic role of estrogen in ovarian tumours. Her-2 neu was expressed mainly in malignant tumours. This suggests their carcinogenic role. This also helps in differentiating borderline and malignant tumours.

scholarly journals RETROSPECTIVE STUDY OF OVARIAN TUMORS AND TUMOR LIKE LESIONS

1969 ◽  
Vol 3 (1) ◽  
pp. 276-281
Author(s):  
NASIM AKHTAR
Keyword(s):  
Germ Cell ◽  
Mucinous Cystadenoma ◽  
Malignant Tumour ◽  
Serous Cystadenoma ◽  
Histological Type ◽  
Germ Cell Tumours ◽  
Neoplastic Lesion ◽  
Significant Difference ◽  
Ovarian Tumours ◽  
Operative Findings

Objective: To find frequency of various Neoplastic and non-neoplastic lesion of the ovaries and to analyzeits clinical presentation.Method: This study was conducted from first July 2007 to 30lh June 2010 in Gynae unit B of DHQ Mardan.All the cases of ovarian Tumours which were initially recruited after ultrasonography and were laterconfirmed by open surgery were included in the study Patients record files were used for collection ofrelevant data including detailed history, examination, investigations and operative findings. All thespecimens were sent for histopathology diagnosis to histopathology section lady reading hospital and a copyof report was attached in patients record files.Result: Out of 7574 Gynanocological admission 191 cases (2.5%) of ovarian Tumours were detected. Nonneo-plastic lesion were more common 98 (51.31%) than neoplastic lesion 93 (48.69%). Among theneoplastic lesion 69.89% were benign while 30% were malignant, serous cystadenoma were the commonestbenign Tumours (35.48%) followed by mucinous cystadenoma (21.50%). Serous cyst adenocarcinoma(10.75%) was the commonest malignant Tumour followed by mucinous cystadenomcarcinoma (8.6%).Average age at presentation was 57 years for malignant ephithelial Tumours, 40 years for gonadal stromalTumours and 22.5 % for germ cell Tumours. There was significant difference in the mean age for benign andmalignant ovarian tumours(34 versus52 p =0.0001)Conclusion:Epithelial ovarian Tumours are the commonest Tumours followed by Germ cell Tumours. Agehas strong correlation with the histological type of the Tumour. Grade, histological type and age of thepatient are important prognostic factors. Ultrasound assessment of risk of malignancy favours better patientmanagement. Menstrual irregularities ,mass and pain abdomen were the commonest clinical presentations.Keywords: Ovarian Tumours, Ovarian neoplasm, Ovarian non-neoplastic lesion.

scholarly journals A study of ovarian tumors at Kathmandu medical college teaching hospital

2017 ◽  
Vol 7 (2) ◽  
pp. 1188-1191 ◽  
Author(s):  
Sailesh Bahadur Pradhan ◽  
Sanat Chalise ◽  
Binita Pradhan ◽  
Sailuja Maharjan
Keyword(s):  
Germ Cell ◽  
Hospital Admissions ◽  
Germ Cell Tumour ◽  
Malignant Neoplasm ◽  
Cystic Teratoma ◽  
College Teaching ◽  
Cell Tumour ◽  
Germ Cell Tumours ◽  
Cross Sectional ◽  
Epithelial Tumours

Background: Ovarian cysts, which present as neoplastic and non-neoplastic lesions, are the most common gynecological cause of hospital admissions. This study was conducted to know the spectrum of ovarian tumors.Materials and methods: A cross sectional study was carried out among all the ovarian specimens sent for histopathological examination.Results: Forty two cases were Surface epithelial tumours and 49 cases were germ cell tumour. Among Surface epithelial tumours, 34 (80.95%) were benign neoplasm, 2(4.76%) were borderline and 6 including one Krukenberg tumour (14.29%) were malignant neoplasm. Among all Germ cell tumours, 45 (91.84%) were Mature cystic teratoma, 1 (4.08%) was Immature cystic teratoma and 2 (4.08%) were Dysgerminoma. Conclusion: Incidence of Surface epithelial tumours and germ cell tumours were found to be almost equal with mild predominance of Germ cell tumour.

scholarly journals Malignant Mixed Germ Cell Ovarian Tumor in Pregnant Female

2013 ◽  
Vol 2 (2) ◽  
pp. 233
Author(s):  
S. Kaur ◽  
V. K. Bodal ◽  
M. S. Bal ◽  
R. Bhagat ◽  
N. Gupta
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Neoplasms ◽  
Abdominal Mass ◽  
Primordial Germ Cells ◽  
Cell Tumor ◽  
Pregnant Female ◽  
Germ Cell Tumours ◽  
Mixed Germ Cell Tumor ◽  
Initial Surgery

Ovarian germ cell tumours comprise approximately 15% to 20% of all ovarian neoplasms. In pregnant females, its incidence is very low. They arise from primordial germ cells derived from the embryonal gonad. Malignant germ cell tumours comprise less than 5% of all ovarian neoplasms. Most malignant ovarian neoplasms in pregnant women are at early stages and are associated with good prognosis both for the mother and for the neonate. Histologic subtypes and prognosis do not differ from tumors not associated with pregnancy. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients. We present a case of malignant mixed germ cell tumor in a pregnant female who presented with abdominal mass after delivering a normal child. Histological and biochemical tumour markers confirmed it to be malignant mixed germ cell tumor.

scholarly journals TO STUDY RELATION BETWEEN SIZE OF OVARY AND VARIOUS HISTOMORPHOLOGICAL PATTERNS

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Archna Ramole ◽  
Tanya Agrawal Chaurasia
Keyword(s):  
Tumour Size ◽  
Germ Cell Tumours ◽  
Malignant Tumours ◽  
Medical College ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Benign Tumours ◽  
Gandhi Medical College

Background & Method: The present study is based on histomorphological evaluation in 214 cases of Ovarian neoplastic and non-neoplastic lesions received at the department of Pathology of a Gandhi Medical College, Bhopal from Apr 2017 to March 2019. Result: All lesions of size 03cm or less are non neoplastic. Of 133 non neoplastic cases, 72 are of size 4 to 6 cm, 36 cases of size 07to 10 cm and 11 cases are >10cm. Out of 47 benign neoplastic lesions 25 are more than 10 cm in size, 18 are of size 07 to 10 cm and 04 cases are of 04 to 06 cm in size.  24 out of 31 malignant cases are more than 10 cm in size, 05 cases are of size 07 to 10 cm and 02 cases are of size 04 to 06 cm. Of tumour size more than 10 cm, 25 are benign tumours and 24 are malignant tumours. Out of 59 cases of size 07 to 10 cm, 36 cases are non neoplastic, 18 cases are benign tumours and 05 are malignant tumours. Conclusion: Among the 214 cases, non neoplastic lesions (62.0%) were more common than the neoplastic lesion (38.0%). Overall incidence of malignancy was 14.4%, and it is 38% among neoplastic lesions. Among 133 non neoplastic lesions studied simple serous cyst (36%) was commonest followed by corpus luteal cyst (25%). Out of 81 tumours, surface epithelial tumours (67.6%) are the commonest ovarian tumours followed by germ cell tumours (24.7%). Keywords: Ovary, Size & Histomorphological. Study Designed: Observational Study.

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