A HISTOPATHOLOGICAL STUDY OF BLADDER TUMORS

Background: The bladder is a common site for urinary tract malignancy. Urinary bladder carcinoma is of global concern and the histopathological types and variants are of relevance for their management. This study was carried out to assess the histopathological characteristics of bladder tumors. Materials and methods: The data was collected retrospectively and prospectively to include a total of 140 urinary bladder tumor specimens. Detailed medical records of these subjects were collected, and histopathological examination was performed on the prospective samples. Results: The most common symptom of bladder tumor was hematuria. Cystoscopy results found grossly visible tumor growths in about 76% subjects. Of the total sample, 84% patients underwent transurethral resection of bladder tumor (TURBT) surgery and the rest of them underwent cystectomy. Furthermore, the commonest histopathological type of urinary bladder carcinoma was invasive urothelial carcinoma. About 68.6% patients had high grade tumor. Most tumor growths were present on the lateral side (46.43%). In 52.86% specimens, deep muscles were involved in the tumor. Node involvement was positive in 11 (47.83%) patients. As per TNM classication, majority of the specimens were pT2bN2Mx (26.09%) and pT2bN0Mx (5, 21.74%). Tumors were detected in stage 2 (26.09%), stage 3 (30.43%) and stage 4 (39.13%). Conclusions: The most common symptom observed in patients with urinary bladder carcinoma was hematuria. Cystoscopy results found 75.71% subjects to have grossly visible tumor growths. The major histopathological type of bladder carcinoma was invasive. In 52.86% specimens, deep muscles were involved in the tumor. About 68.6% patients had high grade tumor.

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Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma

Journal of Clinical Medicine ◽

10.3390/jcm10163683 ◽

2021 ◽

Vol 10 (16) ◽

pp. 3683

Author(s):

Jacek Kudelski ◽

Grzegorz Młynarczyk ◽

Monika Gudowska-Sawczuk ◽

Barbara Mroczko ◽

Barbara Darewicz ◽

...

Keyword(s):

Bladder Cancer ◽

Matrix Metalloproteinases ◽

Urinary Bladder ◽

Matrix Metalloproteinase ◽

Bladder Carcinoma ◽

Urinary Bladder Cancer ◽

Urinary Bladder Carcinoma ◽

Low Grade ◽

High Grade ◽

Human Urinary Bladder

Human urinary bladder cancer is a huge worldwide oncological problem causing many deaths every year. The degradation of extracellular matrix (ECM) induced by molecules such as matrix metalloproteinases (MMPs) is one of the main factors influencing the process of metastasis origination. The MMP expression is tied to tumor aggressiveness, stage, and patient prognosis. The cleavage of constituent proteins is initiated and prolonged by matrix metalloproteinases, such as MMP-3 and MMP-10. The aim of this study was to evaluate the expression and activity of both MMPs in human urinary bladder cancer occurring at various stages of the disease. Tissue samples from patients with urinary bladder cancer were analyzed. Samples were collected from patients with a low- and high-grade cancer. Control tissue was collected from the site opposite to the tumor. DNA content, MMPs content, and activity of MMP-3 and MMP-10 were measured using ELISA and Western blot techniques. MMP-3 and MMP-10 occur in high molecular complexes in human urinary bladder in healthy and cancerous tissues. Particularly, in high-grade tumors, the content of MMP-10 prevails over MMP-3. The actual and specific activities vary in both grades of urinary bladder cancer; however, the highest activity for MMP-3 and MMP-10 was found in low-grade tissues. In conclusion, MMP-10 had a higher content, but a lower activity in all investigated tissues compared to MMP-3. Generally, obtained results demonstrated a contrary participation of MMP-3 and MMP-10 in ECM remodeling what may be crucial in the pathogenesis of human urinary bladder carcinoma.

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Invasive ultrasound interventions in tumors of the urinary bladder and prostate

Kazan medical journal ◽

10.17816/kazmj81486 ◽

1997 ◽

Vol 78 (3) ◽

pp. 204-206

Author(s):

A. Yu. Zubkov

Keyword(s):

Urinary Bladder ◽

Bladder Carcinoma ◽

Tumor Invasion ◽

Bladder Tumor ◽

Urinary Bladder Carcinoma ◽

Interventional Ultrasound ◽

Urinary Bladder Tumor

The transperioral biopsy of the prostate under sonographic control is performed in 13 patients. The urinary bladder carcinoma is revealed in 4 patients and adenocarcinoma is revealed in 9 patients. The transcutaneous paracentetic nephrostomy under ultrasound control being an effective method of supravesical urine lead is performed in 23 patients with retentional and obstructive affection of upper urinaiy tracts as a result of the urinary bladder tumor invasion. The interventional ultrasound tactics in patients with tumors of the urinary bladder and prostate is perspective.

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