scholarly journals STEROID INDUCED PSYCHOSIS IN A CASE OF ERYTHEMA MULTIFORME MAJOR.

2021 ◽  
pp. 9-10
Author(s):  
Nirali Muchhala ◽  
Nishikant Thorat
Keyword(s):  
Erythema Multiforme ◽  
Outpatient Department ◽  
Course Of Illness ◽  
Holistic Management ◽  
Psychiatric Disturbances ◽  
Erythema Multiforme Major ◽  
Detailed Evaluation ◽  
History Of ◽  
Long Term Prognosis

Corticosteroids have been documented to cause psychiatric disturbances to various degree. We report a case of psychosis in a case of erythema multiforme major treated with steroids that presented to psychiatric outpatient department requiring medical management. A 32 years old female was brought to psychiatry outpatient department following behavioural disturbances. Patient had a history of recently suffering from Erythema Multiforme major following a dose of injectable ceftriaxone. After being treated with injectable and oral dose of corticosteroids she developed behavioural disturbances. On detailed evaluation patient was diagnosed to be suffering from Substance/medication-induced psychotic disorder as per DSM-5. She was started on treatment with Tab. Olanzapine (5mg) HS and Tab. Clonazepam (0.5 mg) HS with which her symptoms improved and remitted completely within few weeks. Corticosteroid induced psychosis can be managed with tapering of steroid dosages and / or addition of psychotropic medication. This case emphasizes on the need of liaison-based approach for a holistic management in such cases.Further research is essential to establish the course of illness and long-term prognosis in these patients

Adenoid Cystic Carcinoma With Sialolithiasis of the Left Submandibular Gland: A Case Report and Literature Review

2018 ◽  
Vol 27 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Satoru Miyabe ◽  
Kenichiro Ishibashi ◽  
Kosuke Saida ◽  
Yukio Fujiyoshi ◽  
Hideo Fukano ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Surgical Specimen ◽  
Adenoid Cystic ◽  
History Of ◽  
Supraomohyoid Neck Dissection ◽  
Additional Procedure ◽  
Long Term Prognosis ◽  
Attending Physician

Adenoid cystic carcinoma is one of the most common salivary gland malignancies with poor long-term prognosis, but the coexistence of sialoliths is extraordinarily rare. In this article, we report a case of 30-year-old woman with a history of submandibular area swelling with intermittent pain increasing during mealtimes that had led her attending physician to diagnose a sialolith in the left submandibular gland on a radiograph 10 years before. However, the surgical specimen proved to be an adenoid cystic carcinoma accompanied with a sialolith. Histopathologically, the submandibular gland was displaced with a fibrous granulation tissue containing a small cribriform carcinoma invading the extracapsular region of the gland. We performed fluorescence in situ hybridization examination with an MYB-NFIB fusion probe of the lesion, with positive results. The patient underwent a supraomohyoid neck dissection as additional procedure because of the possibility of the extracapsular cancer nest remaining around the submandibular gland, but she remains well and disease free 11 years after the first operation.

scholarly journals Neuropsychological sequelae in Kleine-Levin syndrome: case report

2000 ◽  
Vol 58 (2B) ◽  
pp. 531-534 ◽  
Author(s):  
LEONARDO FONTENELLE ◽  
MAURO V. MENDLOWICZ ◽  
J. CHRISTIAN GILLIN ◽  
PAULO MATTOS ◽  
MÁRCIO VERSIANI
Keyword(s):  
Case Report ◽  
Early Intervention ◽  
Natural History ◽  
Typical Case ◽  
Social Functions ◽  
Behavioral Disturbances ◽  
Neuropsychological Sequelae ◽  
History Of ◽  
Long Term Prognosis

Kleine-Levin syndrome is characterized by periodic hypersomnia, hyperphagia, sexual disinhibitions and behavioral disturbances. The prognosis is generally benign, with normal cognitive and social functions after the episodes. We describe a typical case of Kleine-Levin syndrome associated with apparent academic decline, neuropsychological sequelae and personality alterations after the second episode of the illness. Further research in the natural history of Kleine-Levin syndrome is needed, for example, to determine whether early intervention would improve long-term prognosis.

scholarly journals Beyond Sector Retinitis Pigmentosa: Expanding the Phenotype and Natural History of the Rhodopsin Gene Codon 106 Mutation (Gly-to-Arg) in Autosomal Dominant Retinitis Pigmentosa

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1853
Author(s):  
Brian G. Ballios ◽  
Emily M. Place ◽  
Luis Martinez-Velazquez ◽  
Eric A. Pierce ◽  
Jason I. Comander ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Autosomal Dominant ◽  
Peripheral Vision ◽  
Visual Fields ◽  
Macular Disease ◽  
History Of ◽  
Intrafamilial Variability ◽  
Long Term Prognosis

Sector and pericentral are two rare, regional forms of retinitis pigmentosa (RP). While usually defined as stable or only very slowly progressing, the available literature to support this claim is limited. Additionally, few studies have analyzed the spectrum of disease within a particular genotype. We identified all cases (9 patients) with an autosomal dominant Rhodopsin variant previously associated with sector RP (RHO c.316G > A, p.Gly106Arg) at our institution. Clinical histories were reviewed, and testing included visual fields, multimodal imaging, and electroretinography. Patients demonstrated a broad phenotypic spectrum that spanned regional phenotypes from sector-like to pericentral RP, as well as generalized disease. We also present evidence of significant intrafamilial variability in regional phenotypes. Finally, we present the longest-reported follow-up for a patient with RHO-associated sector-like RP, showing progression from sectoral to pericentral disease over three decades. In the absence of comorbid macular disease, the long-term prognosis for central visual acuity is good. However, we found that significant progression of RHO p.Gly106Arg disease can occur over protracted periods, with impact on peripheral vision. Longitudinal widefield imaging and periodic ERG reassessment are likely to aid in monitoring disease progression.

Long-term prognosis of patients withJ-wave syndrome

Heart ◽  
2019 ◽  
Vol 106 (4) ◽  
pp. 299-306
Author(s):  
Tsukasa Kamakura ◽  
Tetsuji Shinohara ◽  
Kenji Yodogawa ◽  
Nobuyuki Murakoshi ◽  
Hiroshi Morita ◽  
...  
Keyword(s):  
High Amplitude ◽  
Long Term Study ◽  
St Segment ◽  
History Of ◽  
Provocation Testing ◽  
Long Term Prognosis ◽  
Electrocardiographic Parameters ◽  
The Impact

ObjectiveLimited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF).MethodsThis was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated.ResultsDuring the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence.ConclusionsThis multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.

scholarly journals Fontan circulation and implications for future reproduction

2016 ◽  
Vol 10 (3) ◽  
pp. 104-106
Author(s):  
Niharika Mehta ◽  
Srilakshmi Mitta
Keyword(s):  
Single Ventricle ◽  
Fontan Procedure ◽  
Fontan Circulation ◽  
Cardiac Complications ◽  
Preconception Counseling ◽  
Passive Flow ◽  
History Of ◽  
Future Reproduction ◽  
Long Term Prognosis

This article summarizes and critiques four recent publications looking at preconception counseling, pregnancy outcomes, and cardiac complications in women with history of Fontan circulation. The Fontan procedure is a palliative strategy for single-ventricle type congenital heart disease and involves passive flow of venous return into the pulmonary circulation, bypassing the ventricles. Pregnancy in these patients is not without risk and preconception counseling and contraception practices vary widely. High rates of miscarriage, prematurity, and small-for-gestational-age babies are reported. Cardiac complications include mainly arrhythmias. Whether long-term prognosis in these patients is affected by pregnancy is not yet known.

scholarly journals PREVALENCE AND LONG TERM PROGNOSIS OF PATIENTS WITH COMPLETE LEFT BUNDLE BRANCH BLOCK AND WITHOUT A PRIOR HISTORY OF HEART DISEASE REFERRED FOR NUCLEAR STRESS SPECT

2012 ◽  
Vol 59 (13) ◽  
pp. E1183 ◽  
Author(s):  
Azhar Supariwala ◽  
Seth Uretsky ◽  
Sonal Kamalia ◽  
Narasimhanaidu Guriginjakunta ◽  
Madhusudhan Ponnala ◽  
...  
Keyword(s):  
Heart Disease ◽  
Left Bundle Branch Block ◽  
Prior History ◽  
Bundle Branch Block ◽  
History Of ◽  
Long Term Prognosis

Long term prognosis of the coronary artery with negative echo findings in the cases with a history of Kawasaki disease

1992 ◽  
Vol 1 (1) ◽  
pp. 78
Author(s):  
Tetsuro Kamiya ◽  
Atsuko Suzuki ◽  
Yasuo Ono ◽  
Yoshio Arakaki ◽  
Kenji Kuroe ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
History Of ◽  
Long Term Prognosis

scholarly journals Prevalence and Outcomes of Achromobacter Species Infections in Adults with Cystic Fibrosis: a North American Cohort Study

2017 ◽  
Vol 55 (7) ◽  
pp. 2074-2085 ◽  
Author(s):  
B. D. Edwards ◽  
J. Greysson-Wong ◽  
R. Somayaji ◽  
B. Waddell ◽  
F. J. Whelan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Persistent Infection ◽  
Lung Function Decline ◽  
Multicenter Studies ◽  
Content Type ◽  
History Of ◽  
Long Term Prognosis ◽  
North American Cohort

ABSTRACTAchromobacterspecies are increasingly being detected in cystic fibrosis (CF) patients, with an unclear epidemiology and impact. We studied a cohort of patients attending a Canadian adult CF clinic who had positive sputum cultures forAchromobacterspecies in the period from 1984 to 2013. Infection was categorized as transient or persistent (≥50% positive cultures for 1 year). Those with persistent infection were matched 2:1 with age-, sex-, and time-matched controls without a history ofAchromobacterinfection, and mixed-effects models were used to assess pulmonary exacerbation (PEx) frequency and lung function decline. Isolates from a biobank were retrospectively assessed, identified to the species level bynrdAsequencing, and genotyped using pulsed-field gel electrophoresis (PFGE). Thirty-four patients (11% of those in our clinic), with a median age of 24 years (interquartile range [IQR], 20.3 to 29.8 years), developedAchromobacterinfection. Ten patients (29%) developed persistent infection. Persistence did not denote permanence, as most patients ultimately cleared infection, often after years. Patients were more likely to experience PEx at incident isolation than at prior or subsequent visits (odds ratio [OR], 2.7 [95% confidence interval {CI}, 1.2 to 6.7];P= 0.03). Following persistent infection, there was no difference in annual lung function decline (−1.08% [95% CI, −2.73 to 0.57%] versus −2.74% [95% CI, −4.02 to 1.46%];P= 0.12) or the odds of PEx (OR, 1.21 [95% CI, 0.45 to 3.28];P= 0.70). Differential virulence amongAchromobacterspecies was not observed, and no cases of transmission occurred. We demonstrated that incidentAchromobacterinfection was associated with a greater risk of PEx; however, neither transient nor chronic infection was associated with a worsened long-term prognosis. Large, multicenter studies are needed to clarify the clinical impact, natural history, and transmissibility ofAchromobacter.

Surgical Treatment of Suspected Meningioangiomatosis in the Thoracolumbar Spinal Cord

2020 ◽  
Vol 56 (4) ◽  
Author(s):  
Marie C. Dantio ◽  
Amanda J. Dennis ◽  
Robert L. Bergman
Keyword(s):  
Computed Tomography ◽  
Hind Limb ◽  
Clinical Signs ◽  
Initial Examination ◽  
Limb Ataxia ◽  
Vascular Proliferation ◽  
History Of ◽  
Pelvic Limb ◽  
Long Term Prognosis

ABSTRACT A 5 yr old male neutered Labrador retriever was evaluated for an 8 wk history of a slowly progressive abnormal hind limb gait that did not respond to treatment with nonsteroidal anti-inflammatories. Initial examination findings were mild pelvic limb ataxia and moderate right pelvic limb lameness. A computed tomography with a myelogram was performed and showed a suspected intramedullary spinal mass. MRI was conducted and supported the computed tomography with myelogram findings of a possible intradural spinal mass at L1. A left-sided hemilaminectomy followed by a durotomy at L1 was performed and a firm, tan mass was removed. The histopathologic findings indicated a vascular proliferation most suggestive of a rare proliferative disorder of leptomeningeal blood vessels termed meningioangiomatosis. Although the dog’s signs initially worsened after surgery and he was nonambulatory with marked paraparesis, he regained ambulation within 3–4 wk after the operation. Eighteen months after surgery, he was ambulatory with mild hind limb ataxia with no progression of signs. This case suggests that surgical resection of lesions of suspected meningioangiomatosis can result in improvement of clinical signs with a good long-term prognosis.

Abstract 15337: The Prevalence of Clinically Significant Ischemia in Patients Undergoing Percutaneous Coronary Intervention, a Report From the Multicenter Registry

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Jun Fujita ◽  
Shun Kohsaka ◽  
Ikuko Ueda ◽  
Taku Inohara ◽  
Yuichiro Maekawa ◽  
...  
Keyword(s):  
Coronary Intervention ◽  
Clinical Factors ◽  
Ischemic Region ◽  
Percutaneous Coronary ◽  
Canadian Cardiovascular Society Class ◽  
History Of ◽  
Clinically Significant ◽  
Long Term Prognosis ◽  
Revascularization Procedures

Background: Myocardial perfusion scintigraphy (MPS) plays an important role in the evaluation and quantification of myocardial ischemia, and those with significant ischemia (SI) benefit most from revascularization procedures. This study aimed to identify the clinical factors and anatomical features associated with SI in patients with stable ischemic heart disease (SIHD). Methods and Results: Data were analyzed from 4197 SIHD patients undergoing PCI in The Japan Cardiovascular Database (N = 11,258) between September 2008 and April 2013. MPS was used to evaluate 1070 (25.5%) patients. Significant ischemia (SI) was defined as more than 10% ischemic region. Logistic regression analysis was performed to identify any clinical factors associated with SI. Patients with a history of heart failure, stroke, or anginal symptoms with Canadian Cardiovascular Society class 2 or more were more likely to have SI (odds ratio [OR] 1.63, p = 0.025, OR: 1.85, p = 0.009, and OR: 1.49, p = 0.003, respectively). When angiographic variables were considered, a proximal left anterior descending artery (pLAD) lesion was the sole factor associated with SI (OR: 1.46, p = 0.012) (Table). Importantly, those with SI had more complications (p = 0.006), most notably post-PCI infarcts (p = 0.008) (Figure). Conclusions: Patients’ background data, such as stronger anginal symptoms or a pLAD lesion, were associated with SI. Since patients with SI are necessary to be treated with PCI to improve long-term prognosis, however procedure-related complications happen more frequently than non-SI patients. Physicians must give their full attention to the PCI procedure in SI patients to minimize their complication rate.

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