Histopathology and Renal Function in Wistar Rats after Intravascular Injection of Iodinated Contrast Media Iohexol and Iopamidol

This research aimed to analyze the histopathology (tubular necrosis and proteinaceous casts) and renal function (SCr and BUN) differences of male Wistar strain white rats (Rattus norvegicus) after intravascular injection of iodinated contrast media Iohexol and Iopamidol. This research is an experimental laboratory with a post-test only control group design. Male Wistar rats that fit the criteria were divided into three groups by random sampling technique: Control (K), Treatment 1 (P1, Iohexol 350 mg iodine/mL), and Treatment 2 (P2, Iopamidol 370 mg iodine/mL). Iohexol and Iopamidol were injected at a dose of 1600 mg iodine/kg BW. The histopathology differences were observed under a light microscope with a magnification of 400x, which were analyzed semi-quantitatively through slides formed by the paraffin method and H&E staining. SCr and BUN levels were checked using an automatic analysis machine with blood samples taken through the cardiac ventricle. Kruskal-Wallis test (α= 0.05) on renal histopathology scores, both tubular necrosis and protein casts showed Asymp. Sig. value > 0.05, which means there is no significant difference between the groups (K, P1, and P2). Kruskal-Wallis test (α= 0.05) on SCr levels also showed the Asymp. Sig. value > 0.05 and One-Way ANOVA Comparative Test on BUN levels showed the Sig. value > 0.05 which means there is no significant difference in renal function between the groups. This study proved no difference in histopathology and renal function in Wistar rats after injection of iodinated contrast media Iohexol and Iopamidol.

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Lean body weight versus total body weight to calculate the iodinated contrast media volume in abdominal CT: a randomised controlled trial

Insights into Imaging ◽

10.1186/s13244-020-00920-4 ◽

2020 ◽

Vol 11 (1) ◽

Author(s):

Moreno Zanardo ◽

Fabio Martino Doniselli ◽

Anastassia Esseridou ◽

Massimiliano Agrò ◽

Nicol Antonina Rita Panarisi ◽

...

Keyword(s):

Body Weight ◽

Contrast Media ◽

Controlled Trial ◽

Total Body Weight ◽

Lean Body Weight ◽

Iodinated Contrast Media ◽

Abdominal Ct ◽

Iodinated Contrast ◽

Significant Difference ◽

Total Body

Abstract Objectives Iodinated contrast media (ICM) could be more appropriately dosed on patient lean body weight (LBW) than on total body weight (TBW). Methods After Ethics Committee approval, trial registration NCT03384979, patients aged ≥ 18 years scheduled for multiphasic abdominal CT were randomised for ICM dose to LBW group (0.63 gI/kg of LBW) or TBW group (0.44 gI/kg of TBW). Abdominal 64-row CT was performed using 120 kVp, 100–200 mAs, rotation time 0.5 s, pitch 1, Iopamidol (370 mgI/mL), and flow rate 3 mL/s. Levene, Mann–Whitney U, and χ2 tests were used. The primary endpoint was liver contrast enhancement (LCE). Results Of 335 enrolled patients, 17 were screening failures; 44 dropped out after randomisation; 274 patients were analysed (133 LBW group, 141 TBW group). The median age of LBW group (66 years) was slightly lower than that of TBW group (70 years). Although the median ICM-injected volume was comparable between groups, its variability was larger in the former (interquartile range 27 mL versus 21 mL, p = 0.01). The same was for unenhanced liver density (IQR 10 versus 7 HU) (p = 0.02). Median LCE was 40 (35–46) HU in the LBW group and 40 (35–44) HU in the TBW group, without significant difference for median (p = 0.41) and variability (p = 0.23). Suboptimal LCE (< 40 HU) was found in 64/133 (48%) patients in the LBW group and 69/141 (49%) in the TBW group, but no examination needed repeating. Conclusions The calculation of the ICM volume to be administered for abdominal CT based on the LBW does not imply a more consistent LCE.

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Assessment of Renal Function in the Early Stages of Nephrotoxicity Induced by Iodinated Contrast Media

Nephron ◽

10.1159/000045488 ◽

1999 ◽

Vol 83 (2) ◽

pp. 122-125 ◽

Cited By ~ 20

Author(s):

Shao Bin Duan ◽

Han Wen Wu ◽

Ji An Luo ◽

Fu You Liu

Keyword(s):

Renal Function ◽

Contrast Media ◽

Iodinated Contrast Media ◽

Early Stages ◽

Iodinated Contrast

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Intravascular injection of iodinated contrast media

Clinical Radiology ◽

10.1016/s0009-9260(96)80016-x ◽

1996 ◽

Vol 51 (11) ◽

pp. 820 ◽

Cited By ~ 5

Author(s):

V.P.L. Hornsby

Keyword(s):

Contrast Media ◽

Iodinated Contrast Media ◽

Intravascular Injection ◽

Iodinated Contrast

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High-Osmolar and Low-Osmolar Contrast Media

Acta Radiologica ◽

10.1177/028418519303400301 ◽

1993 ◽

Vol 34 (3) ◽

pp. 205-209 ◽

Cited By ~ 21

Author(s):

H. S. Thomsen ◽

S. Dorph

Keyword(s):

Contrast Media ◽

Observational Studies ◽

Randomized Trials ◽

Iodinated Contrast Media ◽

Intravascular Injection ◽

Small Minority ◽

The Past ◽

Iodinated Contrast ◽

Meta Analyses ◽

Better Than

During the past 3 years a great number of papers about adverse drug reactions to intravascular injection of high-osmolar and low-osmolar iodinated contrast media (CM) have been published. They include observational studies, randomized trials, meta-analyses and committee reports. Thorough analysis of this material substantiates an improvement in safety of at least 6-fold using nonionic low-osmolar CM compared with ionic high-osmolar CM. The point where only a small minority is continuing to argue effectively that low-osmolar CM are not better than conventional high-osmolar CM has now been reached. High-osmolar CM are used less and less for intravascular purposes, and, in fact, have been totally replaced by low-osmolar CM in 4 countries.

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