scholarly journals Clinical Efficacy and Prognosis of the Large Dose Methylprednisolone Impulse Therapy in Combination with the Surgery in Treatment of the Spine Trauma Complicated with the Spinal Cord Injury

2021 ◽  
Vol 83 ◽  
Author(s):  
B. SUN ◽  
X. XIAO ◽  
Z. WU ◽  
Z. WANG ◽  
Q. WANG ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Efficacy ◽  
Large Dose ◽  
Spine Trauma ◽  
Cord Injury

scholarly journals An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Huan-xia Li ◽  
Jing Cui ◽  
Jing-shi Fan ◽  
Jian-zhou Tong
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Hyperbaric Oxygen ◽  
Clinical Efficacy ◽  
Acute Spinal Cord Injury ◽  
Sensory Function ◽  
Control Group ◽  
Thoracolumbar Fractures ◽  
Cord Injury ◽  
Experimental Group

Objective: To examine the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen therapy in treating thoracolumbar vertebral fracture-induced acute spinal cord injury (ASCI). Methods: From June 2015 to May 2018, 80 patients with thoracolumbar fractures and ASCI who were treated at Baoding First Central Hospital were selected. All patients underwent posterior laminectomy and screw fixation, and they were randomly divided into two groups using a random number table method. The control group received conventional postoperative treatment, while the experimental group was treated with riluzole combined with mannitol and hyperbaric oxygen on the basis of conventional treatment. The recovery of nerve function which included motor function and sensory function, and the changes of serum IL-6, CRP, BDNF, BFGF and other factors before treatment and four weeks after treatment of the two groups of patients were observed and evaluated. Results: After treatment, the motor function scores and sensory function scores of the two groups of patients were improved compared with those before treatment (p<0.05). Compared with the control group, the experimental group improved significantly, and the difference was statistically significant (p<0.05). The levels of IL-6, BDNF and NFGF in the experimental group were significantly lower than those in the control group (p<0.05). Conclusions: For patients with thoracolumbar fractures and ASCI undergoing laminar decompression and fixation, the comprehensive treatment plan of riluzole combined with mannitol and hyperbaric oxygen has certain advantages. Compared with the conventional therapy, it may significantly improve the movement and sensory functions of patients, relieve the inflammatory response of spinal cord, and promote recovery from the injury. doi: https://doi.org/10.12669/pjms.37.2.3418 How to cite this:Li H, Cui J, Fan J, Tong J. An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3418 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Spinal Cord Injury after Blunt Cervical Spine Trauma: Correlation of Soft-Tissue Damage and Extension of Lesion

2013 ◽  
Vol 35 (5) ◽  
pp. 1029-1034 ◽  
Author(s):  
R. Martinez-Perez ◽  
I. Paredes ◽  
S. Cepeda ◽  
A. Ramos ◽  
A. M. Castano-Leon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spine ◽  
Soft Tissue ◽  
Tissue Damage ◽  
Soft Tissue Damage ◽  
Cervical Spine Trauma ◽  
Spine Trauma ◽  
Cord Injury

Spine Trauma

2019 ◽  
pp. 255-262
Author(s):  
Timur M. Urakov ◽  
Michael Y. Wang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Vehicle ◽  
Fluid Management ◽  
The Elderly ◽  
Autonomic Dysreflexia ◽  
Spine Trauma ◽  
Vehicle Accidents ◽  
Cord Injury ◽  
Anaesthesia Care

The estimated global incidence of spinal cord injury (SCI) is 250,000 to 500,000 people a year. North America tends to have higher rates of incidence of SCI than Europe. Statistically, young adults and the elderly are more likely to be injured. Motor vehicle accidents are the leading cause of SCI in the world, followed by falls, violence, sports, recreational activities, and iatrogenic sources. This chapter on spine trauma includes elements of anatomy and anaesthesia care for acute cervical spine cord injury (including airway management, blood pressure management, fluid management, hypothermia, monitoring, and steroids). It also covers anaesthesia care for chronic spinal cord injury (including autonomic dysreflexia, physiological changes in chronic SCI patients, and obstetrics).

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