Water coning is one of the most serious problems encountered in active bottom-water drive reservoir. It increases the cost of production operations, reduces the efficiency of the depletion mechanism, and decreases the overall oil recovery. Therefore, preventive measures to curtail water coning damaging effects should be well delineated at the early stages of reservoir depletion. Production rate, mobility ratio, well completion design, and reservoir anisotropy are few of the major parameters influencing and promoting water coning. The objective of this paper is to develop a depletion strategy for an active bottom-water drive reservoir that would improve oil recovery, reduce water production due to coning, delay water breakthrough time, and pre-identify wells that are candidates to excessive water production. The proposed depletion strategy does not only take into consideration the reservoir conditions, but also the currently available surface production facilities and future development plan. Analytical methods are first used to obtain preliminary estimates of critical production rate and water breakthrough time, then comprehensive numerical investigation of the relevant parameters affecting water coning behavior is conducted using a single well 3D radial reservoir simulation model.