The clinical significance of food animal allergens

Animal foods products contain the most balanced complex of essential nutrients. The clinical manifestations of allergy to these products are varied. Key aspect of this problem is diagnostics and assessment of cross-reactivity. The food animal products that more often induce symptoms include cow’s milk, hen’s egg, fish, mollusks, crustaceans, mammalian meat. Data on the main classes of food animal allergens inducing the development of cross-allergic reactions as well as syndromes associated with cross-reactivity like «bird-egg», «cat-pork», «fish-chicken» and a-Gal-syndrome/«red meat syndrome» are described in this article.

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КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ПИЩЕВЫХ АЛЛЕРГЕНОВ ЖИВОТНОГО ПРОИСХОЖДЕНИЯ

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/raj.2019.1-1.53221 ◽

2019 ◽

Author(s):

A.N. Pampura ◽

E.E. Varlamov

Keyword(s):

Clinical Manifestations ◽

Red Meat ◽

Cross Reactivity ◽

Allergic Reactions ◽

Essential Nutrients ◽

Animal Products ◽

Food Animal ◽

Mammalian Meat

Продукты животного происхождения обладают наиболее сбалансированным комплексом необходимых нутриентов, поэтому их включение в пищевой рацион оправданно в различные возрастные периоды. Клинические проявления аллергии к данным продуктам крайне разнообразны. Одним из ключевых аспектов обозначенной проблемы является диагностика и оценка вероятности развития перекрестной реактивности. К пищевым продуктам животного происхождения, наиболее часто индуцирующим симптомы, относятся коровье молоко, куриное яйцо, рыба, моллюски, ракообразные, мясо млекопитающих. В представленной статье изложены данные об основных классах пищевых аллергенов животного происхождения, индуцирующих развитие перекрестных аллергических реакций. Описаны синдромы, связанные с перекрестной реактивностью: птица-яйцо , кошка-свинина , рыба-курица и -Gal-синдром/ синдром красного мяса .Animal foods products contain the most balanced complex of essential nutrients. The clinical manifestations of allergy to these products are varied. Key aspect of this problem is diagnostics and assessment of cross-reactivity. The food animal products that more often induce symptoms include cows milk, hens egg, fish, mollusks, crustaceans, mammalian meat. Data on the main classes of food animal allergens inducing the development of cross-allergic reactions as well as syndromes associated with cross-reactivity like bird-egg , cat-pork , fish-chicken and a-Gal-syndrome/ red meat syndrome are described in this article.

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Quinolone Allergy

Pharmacy ◽

10.3390/pharmacy7030097 ◽

2019 ◽

Vol 7 (3) ◽

pp. 97 ◽

Cited By ~ 9

Author(s):

Edoabasi U. McGee ◽

Essie Samuel ◽

Bernadett Boronea ◽

Nakoasha Dillard ◽

Madison N. Milby ◽

...

Keyword(s):

Clinical Manifestations ◽

Provocation Test ◽

Cross Reactivity ◽

Skin Tests ◽

Diagnostic Tools ◽

In Vitro Tests ◽

Allergic Reactions ◽

Drug Induced ◽

Delayed Reaction

Quinolones are the second most common antibiotic class associated with drug-induced allergic reactions, but data on quinolone allergy are scarce. This review article discusses the available evidence on quinolone allergy, including prevalence, risk factors, diagnosis, clinical manifestations, cross-reactivity, and management of allergic reactions. Although the incidence of quinolone allergy is still lower than beta-lactams, it has been increasingly reported in recent decades, most likely from its expanded use and the introduction of moxifloxacin. Thorough patient history remains essential in the evaluation of quinolone allergy. Many diagnostic tools have been investigated, but skin tests can yield false-positive results and in vitro tests have not been validated. The drug provocation test is considered the test of choice to confirm a quinolone allergy but is not without risk. Evidence regarding cross-reactivity among the quinolones is limited and conflicting. Quinolone allergy can be manifested either as an immediate or delayed reaction, but is not uniform across the class, with moxifloxacin posing the highest risk of anaphylaxis. Quinolone should be discontinued when an allergic reaction occurs and avoided in future scenarios, but desensitization may be warranted if no alternatives are available.

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Hen’s egg allergy: an update

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2018-2-156-166 ◽

2018 ◽

Vol 17 (2) ◽

pp. 156-166

Author(s):

M. M. Fedotova ◽

O. S. Fedorova ◽

U. V. Konovalova ◽

E. M. Kamaltynova ◽

T. A. Nagaeva ◽

...

Keyword(s):

Clinical Presentation ◽

Binding Capacity ◽

Clinical Manifestations ◽

Cross Reactivity ◽

Current Data ◽

Egg Allergy ◽

Ige Binding ◽

Hen’S Egg ◽

Allergenic Proteins ◽

Common Problems

Hen’s egg allergy is one of the most common problems in pediatrics. This pathology is associated with severe clinical manifestations, often with a risk of anaphylactic reactions. This review presents current data on the epidemiology and clinical presentation, as well as aspects of the natural history and management of hen’s egg allergy. The paper will provide data on allergenic proteins of hen’s egg, including data on structure, physicochemical properties, IgE-binding capacity, and cross-reactivity. Finally, practical information about egg allergy and immunization will be presented.

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Nutritional B12 Deficiency in Infants of Vitamin B12-Deficient Mothers

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000080 ◽

2011 ◽

Vol 81 (5) ◽

pp. 328-334 ◽

Cited By ~ 6

Author(s):

Oya Halicioglu ◽

Sezin Asik Akman ◽

Sumer Sutcuoglu ◽

Berna Atabay ◽

Meral Turker ◽

...

Keyword(s):

Megaloblastic Anemia ◽

Maternal Diet ◽

Clinical Manifestations ◽

Serum Vitamin ◽

Failure To Thrive ◽

Clinical Findings ◽

Vitamin B ◽

Animal Products ◽

Hematological Evaluation ◽

Nutritional Vitamin

Aim: Nutritional vitamin B12 deficiency in infants may occur because the maternal diet contains inadequate animal products. Clinical presentations of the infants who had nutritional vitamin B12 deficiency were analyzed in this study. Subjects and Methods: Patients with nutritional vitamin B12 deficiency were enrolled in the study between 2003 and 2010. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. Results: Thirty children aged 1 - 21 months constituted the study group. Poverty was the main cause of inadequate consumption of animal products of the mothers. All infants had predominantly breastfed. The most common symptoms were developmental delay, paleness, apathy, lethargy, anorexia, and failure to thrive. Hematological findings were megaloblastic anemia (83.3 %), thrombocytopenia (30 %), and severe anemia (13.3 %). All of the mothers had low serum B12 levels; eight of them had megaloblastic anemia. Conclusion: The unusual clinical manifestations of vitamin B12 deficiency may also be seen apart from neurological and hematological findings. Nutritional vitamin B12 deficiency due to maternal deficiency might be a serious health problem in infants. Therefore, screening and supplementation of pregnant and lactating women to prevent infantile vitamin B12 deficiency should be considered.

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Allergens from Edible Insects: Cross-reactivity and Effects of Processing

Current Allergy and Asthma Reports ◽

10.1007/s11882-021-01012-z ◽

2021 ◽

Vol 21 (5) ◽

Author(s):

Laura De Marchi ◽

Andrea Wangorsch ◽

Gianni Zoccatelli

Keyword(s):

Food Processing ◽

Cross Reactivity ◽

Allergic Reactions ◽

Edible Insects ◽

Insect Allergy ◽

Crucial Information ◽

Inhalant Allergens ◽

Minor Allergens

Abstract Purpose of Review The recent introduction of edible insects in Western countries has raised concerns about their safety in terms of allergenic reactions. The characterization of insect allergens, the sensitization and cross-reactivity mechanisms, and the effects of food processing represent crucial information for risk assessment. Recent Findings Allergic reactions to different insects and cross-reactivity with crustacean and inhalant allergens have been described, with the identification of new IgE-binding proteins besides well-known pan-allergens. Depending on the route of sensitization, different potential allergens seem to be involved. Food processing may affect the solubility and the immunoreactivity of insect allergens, with results depending on species and type of proteins. Chemical/enzymatic hydrolysis, in some cases, abolishes immunoreactivity. Summary More studies based on subjects with a confirmed insect allergy are necessary to identify major and minor allergens and the role of the route of sensitization. The effects of processing need to be further investigated to assess the risk associated with the ingestion of insect-containing food products.

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Iodine allergy: Common misperceptions

American Journal of Health-System Pharmacy ◽

10.1093/ajhp/zxab033 ◽

2021 ◽

Author(s):

Nicole R Wulf ◽

John Schmitz ◽

Amy Choi

Keyword(s):

Literature Review ◽

Adverse Reactions ◽

Povidone Iodine ◽

Cross Reactivity ◽

Current Evidence ◽

Allergic Reactions ◽

Iodinated Contrast Media ◽

Inclusion Criteria ◽

Iodinated Contrast ◽

Final Article

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose The current evidence regarding iodine-containing compounds and iodine allergy cross-reactivity is reviewed. Summary Iodine is an essential human nutrient found in the thyroid gland. It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report having adverse reactions to iodine-containing substances are often labelled as having an “iodine allergy,” which can result in delays in care or patients being denied essential ICM or other iodine-containing drugs. A literature review was conducted to evaluate the evidence regarding iodine allergy and iodine-containing drugs. Of 435 articles considered potentially appropriate for full review (plus 12 additional articles included on the basis of references from the eligible articles), 113 could not be obtained. After exclusion of 353 articles that did not meet all inclusion criteria, the remaining 81 articles were included in the review. The results of the literature review indicated that iodine has not been shown to be the allergen responsible for allergic reactions to iodinated contrast media, amiodarone, povidone-iodine, and other iodine-containing compounds. Conclusion There is a lack of evidence to support cross-reactivity between iodine-containing compounds in so called iodine-allergic individuals.

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New perspectives on propofol allergy

American Journal of Health-System Pharmacy ◽

10.1093/ajhp/zxab298 ◽

2021 ◽

Author(s):

Jessica L Johnson ◽

Ashley Hawthorne ◽

Michael Bounds ◽

David J Weldon

Keyword(s):

Alternative Therapy ◽

Clinical Trial Data ◽

Cross Reactivity ◽

Food Allergies ◽

Critical Examination ◽

Evidence Based ◽

Allergic Reactions ◽

Definitive Evidence ◽

Medication Costs ◽

History Of

Abstract Purpose Propofol is an intravenous sedative used in many patient populations and care settings. Although generally considered safe and effective, the drug has historically been avoided in patients with reported allergies to egg, soy, and/or peanut on the basis of the manufacturer’s prescribing information. Concerns exist for potential adverse events, increased medication costs, reduced efficacy, and risk of medication errors when using alternative agents. Here we present a critical examination of the literature concerning cross-reactivity of food allergies with propofol to provide evidence-based recommendations for the evaluation and management of potential allergic reactions. Summary Literature regarding the history of propofol allergy warnings and clinical trial data were assessed to provide an alternative perspective on avoidance of propofol in patients with food allergies. Suspected trigger molecules are discussed with evaluation of the antigenic potential of excipient ingredients used in the manufacture of multiple propofol formulations. Evidence-based recommendations are provided for pharmacist-led screening of adult patients with reported food allergies to support selection of propofol or alternative therapy. Conclusion There is a lack of definitive evidence that propofol must be routinely avoided in patients with reported allergies to egg, soy, and/or peanut products. Data from clinical trials suggest that propofol is safe for patients with nonanaphylactic food allergies. Patients who do experience allergic reactions following administration of propofol should undergo further testing to definitively identify the specific trigger and prevent future unnecessary avoidance of preferred medication regimens. Pharmacists can play an important role in interviewing patients with reported food allergies to better determine the risk vs benefit of propofol avoidance.

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