scholarly journals PROGNOSTIC SIGNIFICANCE OF BLOOD MARKER OF HYPERTROPHY– CARDIOTROPHIN-1 WHEN CARRYING DIFFERENT VARIANTS OF ITS GENE IN MEN WITH ESSENTIAL HYPERTENSION

2021 ◽  
Vol 74 (2) ◽  
pp. 273-277
Author(s):  
Maryna O. Matokhniuk ◽  
Oleksandr V. Limanskiy ◽  
Olena V. Maiko ◽  
Vadym Zhebel ◽  
Oleksandra K. Shevchuk ◽  
...  
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Chronic Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Prognostic Significance ◽  
Left Ventricular ◽  
Gene Variants ◽  
Its Gene ◽  
Blood Marker

The aim: To improve diagnosis of essential hypertension with left ventricular hypertrophy and chronic heart failure in men citizens of Podillya region in Ukraine by determining the plasma levels of cardiotrophin-1 in patients with different CT-1 gene variants. Materials and methods: A total of 70 men with no signs of cardiovascular disease and 100 patients with essential hypertension were examined. Among those, 50 participants had hypertension and left ventricular hypertrophy. Other 50 patients had hypertension complicated by chronic heart failure. Results: It was established that in patients with essential hypertension the frequency of the pool of genotypes GA + AA is higher than the genotype GG (p <0.05). Plasma CT-1 levels ≥ 122,895 pg / ml can be used for early diagnosis left ventricular hypertrophy, and the cut-off level is ≥ 303.81 pg / ml (sensitivity 85.7%, specificity 92%) for screening diagnosis of essential hypertension complications in the form of chronic heart failure. Conclusions: In patients with essential hypertension of varying severity, the GA+АА genotypes of CT-1 gene was found to be dominant. They had higher levels of plasma concentration CT-1. The threshold levels of CT-1 for screening diagnosis of essential hypertension with hypertrophy and chronic heart failure in males (who were residents of the Podillya region of Ukraine) were evaluated.

Abstract 237: Prognostic Significance of Left Ventricular Hypertrophy (lvh) by Electrocardiography in a Minority-predominant Heart Failure (hf) Cohort

2016 ◽  
Vol 9 (suppl_2) ◽  
Author(s):  
Muhammad U Majeed ◽  
Abdullahi Oseni ◽  
Olabisi Akanbi ◽  
Vincent Agboto ◽  
Henry E Okafor
Keyword(s):  
Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Prognostic Significance ◽  
Left Ventricular ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
P Value ◽  
Cardiovascular Morbidity And Mortality ◽  
The Impact

Background: Left ventricular Hypertrophy (LVH) has been associated with higher cardiovascular morbidity and mortality but most of these studies were conducted in majority (white) populations. LVH is known to be more common in African Americans (AA) who also have a higher prevalence of cardiovascular morbidity and mortality. The prognostic significance of LVH in AA with Heart Failure (HF) has not been well studied. Methods: We performed a retrospective analysis of a predominantly minority HF cohort (69.3% AA); after obtaining approval from our institutional review board. Our primary goal was to compare the HF outcomes [All-cause hospitalizations (ACH), hospitalizations primarily due to HF and ER visits] in patients with EKG evidence of LVH versus those without LVH. We also examined the racial (Blacks vs Whites), gender (males vs females) and age-based (≥60 Vs <60 years) differential impact of LVH on HF outcomes and determined the prevalence of LVH in the cohort. Levene’s Test and t-test were used to analyze the data for equality of variances and means respectively. Result: Our HF cohort consisted of 599 patients (415 AA, 142 Caucasian, 22 others, 20 unknown). The prevalence of LVH in overall cohort was 26.7%. We noted that black had higher prevalence of LVH ( 31%) vs Whites (15.5%) while prevalence of LVH was not very different in males ( 27.9%) vs females( 25.7%) and ≥60 years of age( 27.5%) vs <60 (27.3%). The analysis showed that there were statistically significant differences in the number of ACH (p-value = 0.014), HF hospitalizations (p-value = 0.019) and ER visits (p-value = 0.001) in the LVH group compared with the non-LVH group. . There were no racial, gender or age-based statistically significant differences in the impact of LVH on HF outcomes. Conclusion: Electrocardiographically determined LVH in a minority - predominant HF cohort is associated with worse outcomes. This needs to be prospectively validated in a larger cohort of HF and could serve as a prognostic marker to guide the care of HF patients.

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