Application of gene therapy in auditory system diseases

How to prevent and treat auditory related diseases through genetic intervention is a hotspot in the field of hearing research in recent years. With the development of molecular biology, molecular genetics, genetic engineering, etc., especially, gene regulation has made a major breakthrough in the research of inner ear hair cell regeneration in recent years, which may provide us with a novel and efficient way to treat auditory related diseases. This review includes the latest research on gene therapy in hereditary deafness, drug deafness, aging-related hearing loss, and noise-related hearing loss.

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Hair Cell Regeneration in the Mammalian Ear, Is Gene Therapy the Answer?

IFMBE Proceedings - 26th Southern Biomedical Engineering Conference SBEC 2010, April 30 - May 2, 2010, College Park, Maryland, USA ◽

10.1007/978-3-642-14998-6_11 ◽

2010 ◽

pp. 42-44

Author(s):

Matthew W. Kelley

Keyword(s):

Gene Therapy ◽

Hair Cell ◽

Cell Regeneration ◽

Hair Cell Regeneration

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Gene therapy for hair cell regeneration: Review and new data

Hearing Research ◽

10.1016/j.heares.2020.107981 ◽

2020 ◽

Vol 394 ◽

pp. 107981 ◽

Cited By ~ 2

Author(s):

Seiji B. Shibata ◽

Matthew B. West ◽

Xiaoping Du ◽

Yoichiro Iwasa ◽

Yehoash Raphael ◽

...

Keyword(s):

Gene Therapy ◽

Hair Cell ◽

Cell Regeneration ◽

Hair Cell Regeneration

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Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?

Hearing Research ◽

10.1016/j.heares.2016.12.011 ◽

2017 ◽

Vol 349 ◽

pp. 182-196 ◽

Cited By ~ 11

Author(s):

Fei Zheng ◽

Jian Zuo

Keyword(s):

Hearing Loss ◽

Hair Cell ◽

Cell Regeneration ◽

Noise Induced Hearing Loss ◽

Hair Cell Regeneration ◽

Cochlear Hair Cell

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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience ◽

10.3389/fncel.2021.732507 ◽

2021 ◽

Vol 15 ◽

Author(s):

Shan Xu ◽

Ning Yang

Keyword(s):

Hearing Loss ◽

Hair Cell ◽

Sensorineural Hearing Loss ◽

Hair Cells ◽

Molecular Mechanisms ◽

Sensorineural Hearing ◽

Research Progress ◽

Cell Regeneration ◽

Hair Cell Regeneration ◽

Auditory Hair Cells

Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss. The damage and loss of hair cells are mainly caused by factors such as aging, infection, genetic factors, hypoxia, autoimmune diseases, ototoxic drugs, or noise exposure. In recent years, research on the regeneration and functional recovery of mammalian auditory hair cells has attracted more and more attention in the field of auditory research. How to regenerate and protect hair cells or auditory neurons through biological methods and rebuild auditory circuits and functions are key scientific issues that need to be resolved in this field. This review mainly summarizes and discusses the recent research progress in gene therapy and molecular mechanisms related to hair cell regeneration in the field of sensorineural hearing loss.

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Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies

Brain Sciences ◽

10.3390/brainsci10100756 ◽

2020 ◽

Vol 10 (10) ◽

pp. 756

Author(s):

Patricia M. White

Keyword(s):

Hearing Loss ◽

Social Context ◽

Hair Cell ◽

Hair Cells ◽

Cell Regeneration ◽

Hair Cell Regeneration ◽

Human Hearing ◽

New Research

Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration. Birds and fish can spontaneously regenerate lost hair cells through a process that has become better defined in the last few years. Findings from these studies have informed new research on hair cell regeneration in the mammalian cochlea. Hair cell regeneration is one part of the greater problem of hearing restoration, as hearing loss can stem from a myriad of causes. This review discusses these issues and recent findings, and places them in the greater social context of need and community.

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