Reprogramming of mouse bone marrow mesenchymal stem cells, mouse bone marrow mononuclear cells and mouse embryonic fibroblasts into induced pluripotent stem cells: a comparison of efficiencies

2014 ◽  
Vol 33 (12) ◽  
pp. 1304-1311
Author(s):  
Yao WANG ◽  
Lei WANG ◽  
Yu-hua LU ◽  
Xiang-jun FAN ◽  
Ming-yan ZHU ◽  
...  
2020 ◽  
Vol 21 (18) ◽  
pp. 6718
Author(s):  
Satoshi Suda ◽  
Chikako Nito ◽  
Shoji Yokobori ◽  
Yuki Sakamoto ◽  
Masataka Nakajima ◽  
...  

Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.


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