The Synthesis and Physico-chemical Characterization of Anthocyan-magnesium Compound

2008 ◽  
Vol 59 (7) ◽  
Author(s):  
Cerasela Elena Gird ◽  
Ligia Elena Dutu ◽  
Teodora Dalila Balaci ◽  
Veronica Naceas

This paper presents the results of the studies regarding the obtaining and the physico- chemical characterization of the semi-synthesis compound called anthocyan-magnesium. The coupling of the anthocyans extracted from Ribes nigrum L. (black currant) with magnesium had the purpose to sum the therapeutic properties of the two components. The anthocyanic extract contains up to 22.4 � 24.0% anthocyans (expressed in cyanidin chloride). The anthocyan-magnesium compound contains 13.37 � 15.25% anthocyans, 11.23 � 11.29% magnesium ions (14 mEg) and 1.56 � 1.96% potassium ions. Spectral methods (IR and UV-VIS spectroscopy) and magnetic determinations confirm the structure of the semisynthetic compound. The coupling of the anthocyans extracted from Ribes nigrum L. (black currant) with magnesium had the purpose to sum the therapeutic properties of the two components. The anthocyanic extract contains up to 22.4 � 24.0% anthocyans (expressed in cyanidin chloride). The anthocyan-magnesium compound contains 13.37 � 15.25% anthocyans, 11.23 � 11.29% magnesium ions (14 mEg) and 1.56 � 1.96% potassium ions. Spectral methods (IR and UV-VIS spectroscopy) and magnetic determinations confirm the structure of the semisynthetic compound.

Author(s):  
Olufunso O. Abosede

Abstract: In the recent past, the pharmaceutical modification of drug molecules by complexation with biologically relevant metals to improve their properties such as stability, dissolution rate, absorption and bioavailability has been extensively studied. In order to achieve better and enhanced medicinal activity, vanadyl complexes of the widely used lincomycin (Lin-van) and neomycin (Neo-van) have been synthesized and their physico-chemical properties examined. The UV-Vis absorption properties of these complexes were determined and their antimicrobial activities were tested against some pathogenic organisms viz: Proteus vulgaris, Klebsiella pneumonae, Escherichia coli and Staphylococcus aureus. In all cases, Neo-van showed better antimicrobial activity than Lin-van while both complexes showed better activity than the antibiotic lincomycin and the previously reported Cu-Lin. Keywords: lincomycin, neomycin, UV-Vis spectroscopy, Physico-chemical, Oxovanadyl, synthesis


Alergologia ◽  
2020 ◽  
Vol 1 (4) ◽  
pp. 7
Author(s):  
Mariana Vieru ◽  
Florin-Dan Popescu ◽  
Laura Haidar ◽  
Carmen Bunu-Panaitescu

2010 ◽  
Vol 35 (5) ◽  
pp. 261-267 ◽  
Author(s):  
Wissemn Gallala ◽  
Mohamed Essghaier Gaied ◽  
Borhen Kchaou

2001 ◽  
Vol 71 (3) ◽  
pp. 342-349
Author(s):  
Lucian Eva ◽  
Letitia Doina Duceac ◽  
Liviu Stafie ◽  
Constantin Marcu ◽  
Geta Mitrea ◽  
...  

The fourth generation cephalosporin antibacterial agent, cefepime, was loaded into layered double hydroxides for enhancing antibiotic efficiency, reducing side effects, as well as achieving the sustained release property. The intercalation of antibiotic into the inter-gallery of ZnAl-layered double hydroxide (LDH) was carried out using ion exchange method, by this constituting a nano-sized organic-inorganic hybrid material for a controlled release novel formulation. Although cefepime is a broad spectrum antibiotic, it has various adverse effects and a significant degradation rate. Thus, the preparation and physico-chemical characterization of nanomaterials able to intercalate this drug is an important study for medical and pharmaceutical field. The antibiotic inclusion into LDHs nanostructure was confirmed by advanced characterization techniques and the release profile of cefepime was analysed with the respect to pH of the simulated media.


2012 ◽  
Vol 358 (23) ◽  
pp. 3280-3288 ◽  
Author(s):  
S. Petrescu ◽  
M. Constantinescu ◽  
E.M. Anghel ◽  
I. Atkinson ◽  
M. Olteanu ◽  
...  

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