scholarly journals Synthesis, UV-Vis Spectroscopic and Physico-chemical Characterization of Oxovanadyl Complexes of Lincomycin and Neomycin

Author(s):  
Olufunso O. Abosede

Abstract: In the recent past, the pharmaceutical modification of drug molecules by complexation with biologically relevant metals to improve their properties such as stability, dissolution rate, absorption and bioavailability has been extensively studied. In order to achieve better and enhanced medicinal activity, vanadyl complexes of the widely used lincomycin (Lin-van) and neomycin (Neo-van) have been synthesized and their physico-chemical properties examined. The UV-Vis absorption properties of these complexes were determined and their antimicrobial activities were tested against some pathogenic organisms viz: Proteus vulgaris, Klebsiella pneumonae, Escherichia coli and Staphylococcus aureus. In all cases, Neo-van showed better antimicrobial activity than Lin-van while both complexes showed better activity than the antibiotic lincomycin and the previously reported Cu-Lin. Keywords: lincomycin, neomycin, UV-Vis spectroscopy, Physico-chemical, Oxovanadyl, synthesis

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2103
Author(s):  
Saša Prđun ◽  
Lidija Svečnjak ◽  
Mato Valentić ◽  
Zvonimir Marijanović ◽  
Igor Jerković

Chemical characterization of bee pollen is of great importance for its quality estimation. Multifloral and unifloral bee pollen samples collected from continental, mountain and Adriatic regions of Croatia were analyzed by means of physico-chemical, chromatographic (GC-MS), and spectroscopic (FTIR-ATR) analytical tools, aiming to conduct a comprehensive characterization of bee pollen. The most distinctive unifloral bee pollen with regard to nutritional value was Aesculus hippocastanum (27.26% of proteins), Quercus spp. (52.58% of total sugars), Taraxacumofficinale (19.04% of total lipids), and Prunusavium (3.81% of ash). No statistically significant differences between multifloral and unifloral bee pollen from different regions were found for most of the physico-chemical measurement data, with an exception of melezitose (p = 0.04). Remarkable differences were found among the bee pollen HS VOCs. The major ones were lower aliphatic compounds, monoterpenes (mainly linalool derivatives, especially in Prunusmahaleb and P.avium bee pollen), and benzene derivatives (mainly benzaldehyde in T.officinale and Salix spp.). Aldehydes C9 to C17 were present in almost all samples. FTIR-ATR analysis revealed unique spectral profiles of analyzed bee pollen exhibiting its overall chemical composition arising from molecular vibrations related to major macromolecules—proteins, lipids, and carbohydrates (sugars).


2016 ◽  
Vol 13 (2) ◽  
pp. 197-206
Author(s):  
PR Sheel ◽  
MAH Chowdhury ◽  
M Ali ◽  
MA Mahamud

The soil physico-chemical properties have been disturbed due to long continued intensive agricultural practices. Under this situation we are approaching rapidly to a very strong future challenge in sustaining the quality of our soil. This study was conducted to evaluate the physico-chemical properties of the selected soil series. The area covered Mymensingh and Jamalpur districts of Bangladesh. Soil samples were collected randomly from different profiles of Lokdeo, Tarakanda, Silmondi and Melandah soil series during March-May, 2014 and analysed. All soils were acidic and textural classes were sandy loam, silt loam, loam, and clay loam. Organic matter and total N contents low to very low. Available S content in the upper layers of most soils were medium to optimum and in the deeper layer low to medium. The exchangeable K, Ca and Na contents were also low. The upper layers of all the locations contained higher amounts of available Zn. The available Cu and Fe contents of most soils were very high. The soils of all locations contained very high amount of available Mn except the deeper layers (45-75 cm) of Melandah which contained optimum amount of available Mn. Soil pH showed negative correlation with total N and available S. Total N showed positive correlation with soil OM, available Cu and available S. There was positive correlation between available S and available Mn.J. Bangladesh Agril. Univ. 13(2): 197-206, December 2015


2008 ◽  
Vol 59 (7) ◽  
Author(s):  
Cerasela Elena Gird ◽  
Ligia Elena Dutu ◽  
Teodora Dalila Balaci ◽  
Veronica Naceas

This paper presents the results of the studies regarding the obtaining and the physico- chemical characterization of the semi-synthesis compound called anthocyan-magnesium. The coupling of the anthocyans extracted from Ribes nigrum L. (black currant) with magnesium had the purpose to sum the therapeutic properties of the two components. The anthocyanic extract contains up to 22.4 � 24.0% anthocyans (expressed in cyanidin chloride). The anthocyan-magnesium compound contains 13.37 � 15.25% anthocyans, 11.23 � 11.29% magnesium ions (14 mEg) and 1.56 � 1.96% potassium ions. Spectral methods (IR and UV-VIS spectroscopy) and magnetic determinations confirm the structure of the semisynthetic compound. The coupling of the anthocyans extracted from Ribes nigrum L. (black currant) with magnesium had the purpose to sum the therapeutic properties of the two components. The anthocyanic extract contains up to 22.4 � 24.0% anthocyans (expressed in cyanidin chloride). The anthocyan-magnesium compound contains 13.37 � 15.25% anthocyans, 11.23 � 11.29% magnesium ions (14 mEg) and 1.56 � 1.96% potassium ions. Spectral methods (IR and UV-VIS spectroscopy) and magnetic determinations confirm the structure of the semisynthetic compound.


2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Arif Ali Baig Moghal

In order to explore the possibility of using low-lime fly ashes, the physical and chemical properties which have a direct bearing on their geotechnical and geoenvironmental behaviors have been investigated. In this paper, two types of low-lime fly ashes, originating from India, have been used. A brief account of various methods adopted in characterizing their physical, chemical, and geotechnical properties is presented. The relative importance of each of these properties in enhancing the bulk applicability of fly ashes has been brought out.


2009 ◽  
Vol 15 (5) ◽  
pp. 627-640 ◽  
Author(s):  
Nuno Vale ◽  
Joana Matos ◽  
Rui Moreira ◽  
Paula Gomes

Novel primaquine-derived antimalarials have been extensively characterized by electrospray ionization-ion trap mass spectrometry (ESI-MS). Experiments by in-source collision-induced dissociation (CID) in the nozzle–skimmer region (NSR) or by tandem mass spectrometry (MS/MS) are shown to be most valuable tools for the physico–chemical characterization of these 8-aminoquinolinic drugs that also bear the biologically relevant imidazolidin-4-one scaffold. It was possible to find parallelism between compound stability in the NSR and its reactivity towards hydrolysis at physiological pH and T. Moreover, MS/MS fragmentation patterns were characteristic for each family, providing a means for structural distinction of isomers and allowing interesting correlations to be found between the relative abundance of particular fragments and relevant structure–activity determinants, such as the Charton steric parameter, ν. In conclusion, this work provides a solid ground for establishing ESI-MS as a key tool for the physico–chemical characterization of biopharmaceuticals bearing the 8-aminoquinoline and/or the imidazolidin-4-one moieties.


2021 ◽  
Vol 11 (1) ◽  
pp. 6740-6744
Author(s):  
N. el H. Belkham ◽  
D. Benachour ◽  
A. Mehamha

A hybrid material can be defined as a combination of two components of different chemical nature. The combination of a mineral matrix and organic matter has multiple significance. From a chemical point of view, it allows the obtaining of bi-functional materials that combine the chemical properties of their components. The development of new materials with specific properties and nanostructured Lamellar Double Hydroxides (LDHs) has been widely investigated due to their great importance. This study focuses on the development of a hybrid material consisting of a matrix of alumina trihydrate Al(OH)3 (gibbsite). Previous studies on the synthesis of suspension LDHs by lithium salts intercalation in a gibbsite matrix were examined, while the obtained samples were characterized by different physicochemical methods.


2007 ◽  
Vol 64 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Silvia Antoniali ◽  
Paulo Ademar Martins Leal ◽  
Ana Maria de Magalhães ◽  
Rogério Tsuyoshi Fuziki ◽  
Juliana Sanches

The bell pepper presents alterations in its composition and its properties with the process of senescence during ripening. These composition and textual factors are part of the quality of the fruit and therefore of the selection. This permits the correct knowledge of the factors necessary for post-harvest measures, so that they can be adequately applied. The aim of this study is to analyze the 'Zarco HS' yellow pepper at various levels of ripeness taking into account its physico-chemical properties (titratable acidity, pH, total soluble solids, water content, and ascorbic acid), in order to understand this behavior during the ripening process. Bell peppers were separated based on their yellow percentage, which varied from 0% to 100%, and for each percentage five fruits were chosen as replicates. They were compared to 0%, 25%, 50%, 75% and 100% levels of ripening, due to the difficulty of the methodology in identifying the smaller differences between coloring. The 'Zarco HS' yellow bell pepper presents greater levels of soluble solids and lower levels of malic acid as the percentage of external yellow coloring increases. The yellow bell peppers, especially when totally yellow, represent an important source of vitamin C.


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