CYTOKINE TISSUE PROFILE IN NON-METASTATIC GASTRIC CANCER

The development of the tumor process involves the involvement of various functional elements of innate and adaptive immunity. A special role in the reorganization of tissues, changes and evolution of the properties of cancer cells is given to cytokines, the study of the role of which in these processes with various types of neoplasms and, in particular, with nonmetastatic gastric cancer is an urgent task. The aim of the work was to determine the characteristics of the cytokine status in the tissues of patients with non-metastatic gastric cancer. Materials and methods. In the extracts of tumor tissue, perifocal zone, omentum, peritoneum of patients with gastric cancer without metatstases (T3-4aN0-3M0, n = 20, 58.9 ± 9.7 years), the concentration of IL-1P, IL-2, IL -6, IL-8, IL-18, TNF-a, IL-10 and IL-1RA in tumor tissue, the perifocal zone, as well as in the omentum and peritoneum. Results and discussion. In the tumor tissue, an increase in the content of IL-1P, IL-8 and a decrease in IL-2, TNF-a and IL-10 were noted. In the perifocal zone, a decrease in the concentration of IL-1P, IL-6, IL-8 was revealed with an increased content of IL-2, IL-1RA, IL-10, TNF-a and IL-18. Against this background, the omentum and peritoneum compared with the tumor, the concentration of IL-1P, IL-18 and IL-1RA is reduced, against the background of an increase in the concentration of IL-2, IL-6, TNF-a and IL-10. Findings. It was shown that tumor tissue has some features in the cytokine profile compared with unaffected tissues, which can be used to further evaluate the development of the pathological process.

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The role of chemokines in linking innate and adaptive immunity

Current Opinion in Immunology ◽

10.1016/s0952-7915(01)00308-9 ◽

2002 ◽

Vol 14 (1) ◽

pp. 129-135 ◽

Cited By ~ 337

Author(s):

Andrew D Luster

Keyword(s):

Adaptive Immunity ◽

Innate And Adaptive Immunity

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Axiological contexts of geographical cognition.

European Journal of Geography ◽

10.48088/ejg.v.suk.12.3.102.112 ◽

2021 ◽

Vol 12 (3) ◽

pp. 103-112

Author(s):

Viacheslav D. Sukhorukov ◽

◽

Yuriy N. Gladkiy ◽

Valeriy G. Suslov ◽

◽

...

Keyword(s):

Spatial Interaction ◽

Dominant Role ◽

Special Role ◽

Value Consciousness ◽

Urgent Task ◽

Humanitarian Values ◽

Nature And Society ◽

Geographical Space ◽

Conceptual Progress

The paper reasons about value consciousness, which plays a special role in the study and development of geographical space. The understanding of geographical space is based on multidimensional analytical features of this subject category. Geographical space is represented as an area of mutual penetration of a unique natural shell and an original anthroposphere. In this fusion of nature and society, the predominant role of humans in the surrounding reality is highlighted. It is suggested that the urgent task of geographical knowledge is the need to unite knowledge about people, nature and society in the conditions of spatial interaction. It is emphasized that the main vector of modern geographical research is the conceptual progress from "Earth" to "Person" as the only reliable wealth that the world possesses. The dominant role of a person in the surrounding reality is determined by the moral consciousness and reasonable practice of an individual in specific spatial circumstances. The authors illustrate that in modern conditions it is impossible to do this without appealing to humanitarian values, which become the fundamental basis of the entire world "Dasein” (by M. Heidegger) as an existing being.

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ROLE OF INNATE AND ADAPTIVE IMMUNITY ON ATHEROSCLEROSIS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(19)32473-8 ◽

2019 ◽

Vol 73 (9) ◽

pp. 1867

Author(s):

Maria Cristina Izar ◽

Waleria Fonzar ◽

Francisco Fonseca ◽

Henrique Fonseca ◽

Tuany P. Silva ◽

...

Keyword(s):

Familial Hypercholesterolemia ◽

Adaptive Immunity ◽

Innate And Adaptive Immunity

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Sexual dimorphism in immune function: The role of sex steroid hormones

SHS Web of Conferences ◽

10.1051/shsconf/20185102007 ◽

2018 ◽

Vol 51 ◽

pp. 02007

Author(s):

Anna Mihailova ◽

Indrikis Krams

Keyword(s):

Immune System ◽

Sexual Dimorphism ◽

Infectious Diseases ◽

Immune Function ◽

Steroid Hormones ◽

Adaptive Immunity ◽

Gonadal Hormones ◽

Sex Steroid ◽

Innate And Adaptive Immunity

There is evidence of the relation of sex steroid hormones and sexual dimorphism in immune system response to infectious diseases. The aim of this review was to identify the role of sex hormones in immune function and sexual dimorphism of immune reactions. Gonadal hormones together with the immune system play an important role in process of immune responses to the disease [1]. Estrogens, progesterone and testosterone have different impacts on immune cells and different gonadal hormones are of high importance for responses of innate and adaptive immunity [1, 2]. Estrogens mainly enhance immune function while testosterone has a suppressive role. Higher progesterone during pregnancy leads to autoimmune disease remission and an elevated susceptibility toward certain infectious diseases [2, 3, 4]. The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome could be worse for females [5]. Sexual dimorphism of immune function is based on different concentrations of sex hormones in males and females and on a specific mediating role of these hormones in immune function and response along with differences in innate and adaptive immunity.

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