Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy

Introduction: Ultrasound biomicroscopy (UBM) is the only widely used method for the evaluation of anterior uveal melanoma (AUM). Objective: Documentation of regression of AUM treated with ruthenium-106 (Ru-106) plaque types CCB and CCC using UBM. Methods: This single institution-based retrospective case series involved 10 Caucasian patients with AUM followed after brachytherapy with UBM from January 2014 until February 2019. The largest prominence of the tumor perpendicular to the sclera or the cornea (including scleral/corneal thickness) (D) and the largest basal dimension (B) were measured in millimeters with UBM for all patients prior to the brachytherapy and at 4-month interval follow-up. Tumor regression was calculated as a percentage of decrease in the initial D and B values. Results: The study involved 10 patients with a mean age of 64.4 years (yr) (range 46–80 yr). D ranged from 1.82 to 5.5 mm (median 2.99 mm) and B from 2.32 to 12.38 mm (median 4.18 mm). The apical radiation dose in all patients was 100 Gy. The median follow-up was 42.02 months. Regression for D was 21.11 ± 13.66%, 31.09 ± 14.66%, and 34.92 ± 19.86% at 1st, 2nd, and 3rd year of the follow-up, respectively, while for B it was 21.58 ± 16.05%, 28.98 ± 17.71%, and 32.06 ± 18.96%, respectively. Tumor recurrence was documented in 2/10 patients. Conclusion: The major regression of AUM, treated with Ru-106 plaque types CCB and CCC, was documented in the first 2 years after brachytherapy in our study group. In the following years, only minimal regression was documented that warns of the need for close monitoring and active search for local recurrences.

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Clinical Features of Iris Cysts in Long-Term Follow-Up

Journal of Clinical Medicine ◽

10.3390/jcm10020189 ◽

2021 ◽

Vol 10 (2) ◽

pp. 189

Author(s):

Joanna Konopińska ◽

Łukasz Lisowski ◽

Zofia Mariak ◽

Iwona Obuchowska

Keyword(s):

Visual Acuity ◽

Ultrasound Biomicroscopy ◽

Anatomical Location ◽

Long Term Follow Up ◽

Temporal Quadrant ◽

The Mean ◽

Multiple Cysts ◽

Cyst Growth

This study evaluated the characteristics and clinical course of patients with iris cysts in the long-term follow-up (24–48 months). We retrospectively analyzed the medical records of 39 patients with iris cysts (27 women and 12 men). Age, visual acuity, intraocular pressure (IOP), slit-lamp evaluation, and ultrasound biomicroscopy images were assessed. The mean age at diagnosis was 40.6 ± 17.48 years. Thirty (76.9%) cysts were peripheral, five (12.8%) were located at the pupillary margin, two (5.1%) were midzonal, and two (5.1%) were multichamber cysts extending from the periphery to the pupillary margin. A total of 23 (59%) cysts were in the lower temporal quadrant, 11 (28.2%) were in the lower nasal quadrant, and 5 (12.8%) were in the upper nasal quadrant. Cyst size was positively correlated with patient age (rs = 0.38, p = 0.003) and negatively correlated with visual acuity (rs = −0.42, p = 0.014). Cyst growth was not observed. The only complication was an increase in IOP in three (7.7%) patients with multiple cysts. The anatomical location of the cysts cannot differentiate them from solid tumors. The vast majority of cysts are asymptomatic, do not increase in size, and do not require treatment during long-term follow-up.

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The effectiveness of descemethogoniopuncture depending on the timing of its implementation after microinvasive non-penetrating deep sclerectomy in patients with glaucoma

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-79-82 ◽

2021 ◽

pp. 79-82

Author(s):

E.L. Sorokin ◽

◽

N.V. Postupaeva ◽

◽

Keyword(s):

Intraocular Pressure ◽

Antihypertensive Effect ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Hypotensive Effect ◽

Ultrasound Biomicroscopy ◽

Deep Sclerectomy ◽

Group 2 ◽

Group 1

Purpose. Evaluation of the efficacy of descemethogoniopuncture (DGP) at various times after microinvasive non-penetrating deep sclerectomy (MNPDS) in patients with glaucoma. Material and methods. The analysis of the results of DGP in 64 eyes of patients with primary open-angle glaucoma after previously performed MNPDS. According to the timing of DGP after MNPDS, the patients were divided into 3 groups. In the 1st group BPH was performed after 1–2 months (22 eyes), the 2nd group – after 3–4 months (21 eyes), the 3rd group after 5–6 months (21 eyes). The follow-up period was 1 year. Results. The level of intraocular pressure before DGP averaged 15.1±0.6 mm Hg in group 1, 17.5±0.9 mm Hg in group 2, and group – 18.6±0.7 mm Hg. After DGP, 13.1±0.4 mm Hg, 14.6±0.7 mm Hg, 16.1±0.5 mm Hg respectively. According to ultrasound biomicroscopy, the highest and extended intrascleral cavities and tunnels, as well as a thin loose trabeculodescemet membrane (TDM), were observed in the eyes of the 1st group. With an increase in the time after MNPDS, there was a compaction of TDM, a decrease in the height and length of the intrascleral cavity and tunnels. 12 months after DGP, the most pronounced antihypertensive effect without antihypertensive therapy occurred in group 1 – 55% of cases compared with groups 2 and 3 (33% and 14% respectively). Conclusion. The greatest efficiency was shown by performing DGP within 1–2 months after MNPDS, which is associated with the minimum development of proliferative processes in the intrascleral outflow tract in the early stages after this operation. Key words: descemethogoniopuncture, microinvasive non-penetrating deep sclerectomy, intraocular pressure, hypotensive effect, glaucoma.

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Management of Aphakia with Visual Axis Opacification after Congenital Cataract Surgery Based on UBM Image Features Analysis

Journal of Ophthalmology ◽

10.1155/2020/9489450 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Wensi Chen ◽

Shiping He ◽

Daoman Xiang

Keyword(s):

Cataract Surgery ◽

Mixed Type ◽

Congenital Cataract ◽

Ultrasound Biomicroscopy ◽

Image Features ◽

Imaging Features ◽

Visual Axis ◽

Anterior Vitrectomy ◽

Congenital Cataract Surgery

Objective. The purpose of this study was to study the imaging features of ultrasound biomicroscopy (UBM) in the aphakia with visual axis opacification (VAO) after congenital cataract surgery. Methods. From May 2015 to May 2018, aphakia patients with VAO who underwent congenital cataract surgery were examined by high-resolution bag/balloon UBM technique, and the results of UBM imaging were analyzed. According to UBM imaging features, different types of VAO were classified. Results. A total of 38 children (55 eyes) with VAO were included. 17 patients were bilateral, and 21 patients were unilateral. Patients with VAO were classified into 3 groups according to the UBM imaging features: membranous fibrosis VOA (17 cases, 28 eyes), cortical regeneration VOA (15 cases, 20 eyes), and mixed VOA (6 cases, 7 eyes). The patients in the membranous fibrosis group underwent Nd:YAG laser posterior capsulotomy, those in the cortical regeneration group underwent anterior vitrectomy, and those in the mixed type group underwent anterior vitrectomy with RF capsulotomy tip. After surgery, VAO were removed in all patients. During the follow-up period, in the membranous fibrotic VAO group, iris adhesion and pupillary occlusion were found in 2 eyes, and anterior vitrectomy combined with separation of iris adhesion was performed. In cortical regenerative and mixed type VAO groups, anterior vitrectomy was performed without opacity in the axial region. The total recurrence rate of VAO was 3.46%. Conclusion. After congenital cataract surgery, the UBM imaging features of aphakia with VAO are helpful to evaluate the condition of VAO before reoperation so as to choose the optimal surgical method to achieve better therapeutic effect.

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Long-term evaluation of autologous lamellar corneal grafts for the treatment of deep corneal ulcer in four dogs: a case report

Veterinární Medicína ◽

10.17221/139/2017-vetmed ◽

2019 ◽

Vol 64 (No. 02) ◽

pp. 84-91

Author(s):

SY Kim ◽

JY Kim ◽

SW Jeong

Keyword(s):

Case Report ◽

Corneal Ulcer ◽

Donor Site ◽

Ultrasound Biomicroscopy ◽

Corneal Graft ◽

Corneal Ulcers ◽

Term Evaluation ◽

The Aesthetic

Autologous lamellar corneal grafts were performed on four dogs with two deep corneal ulcers and two corneal perforations to achieve better visual and aesthetic outcomes. The donor corneal graft was harvested from the relatively normal corneal region of the affected eye and used to cover the corneal defect. At the two-year follow-up examination, ultrasound biomicroscopy was performed to confirm the thickness and endothelial continuity of the transplanted grafts and donor site of the cornea. The evaluations revealed that the dogs had healed without incident and that their vision had been maintained. Furthermore, the owners were satisfied with the aesthetic outcomes in all cases. Our findings show that autologous lamellar corneal grafts are useful and effective in treating canine corneal ulcers and perforations.

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Pars plana Ex-Press mini shunt for management of persistent glaucoma in vitrectomized eyes: A novel technique

European Journal of Ophthalmology ◽

10.1177/1120672120914495 ◽

2020 ◽

Vol 30 (5) ◽

pp. 1179-1184 ◽

Cited By ~ 2

Author(s):

Abdussalam Abdullatif ◽

Heba El-Saied

Keyword(s):

Intraocular Pressure ◽

Silicone Oil ◽

Case Series ◽

Ultrasound Biomicroscopy ◽

Secondary Glaucoma ◽

Antiglaucoma Medication ◽

Novel Approach ◽

Pars Plana ◽

Secondary Refractory

Purpose: To evaluate the safety and efficacy of a novel approach to implant Ex-Press mini shunt via the pars plana under a scleral flap in pseudophakic or aphakic, vitrectomized patients with secondary refractory glaucoma. Methods: A prospective interventional case series of three patients with secondary glaucoma after pars plana vitrectomy. Intraocular pressure was not controlled by silicone oil removal, if the patient was siliconized, nor the maximum medical treatment. Ex-Press mini shunt via the pars plana was implanted. We evaluated the control of intraocular pressure and the development of intraoperative and postoperative complications. Results: During 1-year follow-up, control of intraocular pressure was achieved; 14, 15, and 15 mmHg at the 3 months, and 15, 15, and 16 mmHg at the 6 months in our three cases without antiglaucoma treatment and 16, 16, and 18 with single antiglaucoma medication at 1 year. Blebs were posterior and diffuse. No complications were encountered intraoperatively or postoperatively. Ultrasound biomicroscopy showed suprachoroidal posterior lake of fluid as an additional filtration route without any choroidal or retinal complication. Conclusion: Implantation of Ex-Press mini shunt via the pars plana in aphakic or pseudophakic, vitrectomized eyes is a promising, safe, and effective technique in patients with secondary glaucoma.

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Surgical site characteristics after CLASS followed by ultrasound biomicroscopy and clinical grading scale: a 2-year follow-up

Eye ◽

10.1038/s41433-020-01235-w ◽

2020 ◽

Author(s):

Xiaowei Yan ◽

Hengli Zhang ◽

Fan Li ◽

Lihua Ma ◽

Yulei Geng ◽

...

Keyword(s):

Ultrasound Biomicroscopy ◽

Site Characteristics ◽

Grading Scale ◽

Clinical Grading

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Myeloid sarcoma presenting as an unusual limbal mass

BMJ Case Reports ◽

10.1136/bcr-2018-226284 ◽

2019 ◽

Vol 12 (1) ◽

pp. bcr-2018-226284 ◽

Cited By ~ 1

Author(s):

Rachna Meel ◽

Arjun Desai ◽

Nripen Gaur ◽

Sameer Bakhshi

Keyword(s):

Systemic Chemotherapy ◽

Granulocytic Sarcoma ◽

Ultrasound Biomicroscopy ◽

Myeloid Sarcoma ◽

Excision Biopsy ◽

Histopathological Analysis ◽

Ocular Pain ◽

French American British ◽

Acute Myeloid

A 19-year-old woman presented to the outpatient department with occasional ocular pain and redness and a perilimbal mass, which she noticed 5 months ago in her left eye. She had no systemic complaints. Ultrasound biomicroscopy of the mass showed a hypoechoic lesion with uniform reflectivity. The patient underwent an excision biopsy and a histopathological analysis revealed features suggestive of a granulocytic sarcoma/myeloid sarcoma. Further haematopathological evaluation confirmed concurrent acute myeloid (myelomonocytic) leukaemia French American British classification M4. There was complete remission of the ocular surface lesion and leukaemia with systemic chemotherapy. At the last follow-up of 18 months post-treatment the patient is free of disease.

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Trabeculectomy in an unsuspected extramedullary iris–ciliary body plasmacytoma

European Journal of Ophthalmology ◽

10.1177/1120672120920225 ◽

2020 ◽

pp. 112067212092022

Author(s):

Harathy Selvan ◽

Seema Kashyap ◽

Seema Sen ◽

Bhavna Chawla ◽

Neiwete Lomi ◽

...

Keyword(s):

Ciliary Body ◽

Histopathological Examination ◽

Neovascular Glaucoma ◽

Ultrasound Biomicroscopy ◽

Extramedullary Plasmacytoma ◽

Plasma Cell Dyscrasia ◽

Post Operative Period ◽

Bleb Failure ◽

Disease Free

Extramedullary plasmacytoma of the iris and ciliary body is extremely rare. We present a case which was misdiagnosed as granulomatous uveitis with neovascular glaucoma, and underwent a trabeculectomy with mitomycin-c along with iris biopsy. The post-operative period showed early bleb failure and catastrophic growth of the suspected mass. Histopathological examination revealed a diagnosis iris plasmacytoma. Subsequent ultrasound biomicroscopy showed involvement of the iris and ciliary body. A prompt systemic workup was done, and an associated systemic plasma cell dyscrasia was ruled out. The affected eye was enucleated, and the patient remains disease free at the end of 3-year follow-up.

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