Abstract
BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spleen volume formula using the body surface area. We compared the liver volume formula with other four formulas, which be proved with highest accuracy and lowest error. Until now, except for the new spleen volume formula in the research, there are few reports about it.AIMTo obtain a reference range of morphological indices, and to establish a formula to accurately predict the standard liver and spleen volumes in Chinese adults.METHODSComputed tomography was used to calculate the estimated total liver volume and spleen volume of 305 Chinese adults without any diseases which could influence the volumes of these two organs. Gender, age, body height, body weight, body surface area and body mass index were determined. Correlation analysis and step-wise multiple linear regression analysis were performed to evaluate the impact of each parameter on the liver and spleen volumes, and then a formula to predict the liver and spleen volumes was established. Finally, the results obtained with the new liver volume formula with existing formulas in a validation group were compared.RESULTSThe average liver and spleen volume values were 1043.18 ± 244.60 cm3 and 175.07 ± 88.15 cm3, respectively. Age, body height, body weight, body surface area and body mass index were significantly correlated with liver and spleen volume. Body surface area showed the strongest correlation with liver volume and spleen volume( p<0.005 and p<0.001). Based on these results, new formulas to calculate the standard liver volume and standard spleen volume were established.CONCLUSIONSCompared the new liver volume formula with the existing formula, it is found that the new liver volume is more accurate. And the accuracy of the spleen volume formula is acceptable. Core tip: To solve the problem of time-consuming and boring in calculating the liver and spleen volume, we successfully established the liver and spleen volume formula can be used in Chinese adult. Though there are some reports about the liver volume, but it is different in spleen volume. The liver volume and spleen volume radio is an useful index to predict the esophageal varices and bleeding risk for cirrhosis patients. Only liver volume formula is not enough, the finding of the spleen volume is very meaningful.
New formula for predicting standard liver volume in Chinese adults
