New formula for predicting standard liver and spleen volumes in Chinese adults

2019 ◽  
Author(s):  
Longbao Yang ◽  
Gang Zhao ◽  
Xinxing Tantai ◽  
Cailan Xiao ◽  
Caifeng Yang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Liver Volume ◽  
Body Height ◽  
Spleen Volume ◽  
Chinese Adults ◽  
Volume Formula

Abstract BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spleen volume formula using the body surface area. We compared the liver volume formula with other four formulas, which be proved with highest accuracy and lowest error. Until now, except for the new spleen volume formula in the research, there are few reports about it.AIMTo obtain a reference range of morphological indices, and to establish a formula to accurately predict the standard liver and spleen volumes in Chinese adults.METHODSComputed tomography was used to calculate the estimated total liver volume and spleen volume of 305 Chinese adults without any diseases which could influence the volumes of these two organs. Gender, age, body height, body weight, body surface area and body mass index were determined. Correlation analysis and step-wise multiple linear regression analysis were performed to evaluate the impact of each parameter on the liver and spleen volumes, and then a formula to predict the liver and spleen volumes was established. Finally, the results obtained with the new liver volume formula with existing formulas in a validation group were compared.RESULTSThe average liver and spleen volume values were 1043.18 ± 244.60 cm3 and 175.07 ± 88.15 cm3, respectively. Age, body height, body weight, body surface area and body mass index were significantly correlated with liver and spleen volume. Body surface area showed the strongest correlation with liver volume and spleen volume( p<0.005 and p<0.001). Based on these results, new formulas to calculate the standard liver volume and standard spleen volume were established.CONCLUSIONSCompared the new liver volume formula with the existing formula, it is found that the new liver volume is more accurate. And the accuracy of the spleen volume formula is acceptable. Core tip: To solve the problem of time-consuming and boring in calculating the liver and spleen volume, we successfully established the liver and spleen volume formula can be used in Chinese adult. Though there are some reports about the liver volume, but it is different in spleen volume. The liver volume and spleen volume radio is an useful index to predict the esophageal varices and bleeding risk for cirrhosis patients. Only liver volume formula is not enough, the finding of the spleen volume is very meaningful.

scholarly journals Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses

2021 ◽  
Vol 12 ◽  
Author(s):  
Jose M. Serra López-Matencio ◽  
Yaiza Pérez García ◽  
Virginia Meca-Lallana ◽  
Raquel Juárez-Sánchez ◽  
Angeles Ursa ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Plasma Concentration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Treatment Duration ◽  
Pharmacokinetics And Pharmacodynamics ◽  
The Impact

Background: Plasma concentration of natalizumab falls above the therapeutic threshold in many patients who, therefore, receive more natalizumab than necessary and have higher risk of progressive multifocal leukoencephalopathy.Objective: To assess in a single study the individual and treatment characteristics that influence the pharmacokinetics and pharmacodynamics of natalizumab in multiple sclerosis (MS) patients in the real-world practice.Methods: Prospective observational study to analyse the impact of body weight, height, body surface area, body mass index, gender, age, treatment duration, and dosage scheme on natalizumab concentrations and the occupancy of α4-integrin receptor (RO) by natalizumab.Results: Natalizumab concentrations ranged from 0.72 to 67 μg/ml, and RO from 26 to 100%. Body mass index inversely associated with natalizumab concentration (beta = −1.78; p ≤ 0.001), as it did body weight (beta = −0.34; p = 0.001), but not height, body surface area, age or gender Extended vs. standard dose scheme, but not treatment duration, was inversely associated with natalizumab concentration (beta = −7.92; p = 0.016). Similar to natalizumab concentration, body mass index (beta = −1.39; p = 0.001) and weight (beta = −0.31; p = 0.001) inversely impacted RO. Finally, there was a strong direct linear correlation between serum concentrations and RO until 9 μg/ml (rho = 0.71; p = 0.003). Nevertheless, most patients had higher concentrations of natalizumab resulting in the saturation of the integrin.Conclusions: Body mass index and dosing interval are the main variables found to influence the pharmacology of natalizumab. Plasma concentration of natalizumab and/or RO are wide variable among patients and should be routinely measured to personalize treatment and, therefore, avoid either over and underdosing.

Derivation of new reference tables for human heart weights in light of increasing body mass index

2010 ◽  
Vol 64 (4) ◽  
pp. 358-362 ◽  
Author(s):  
Kezia Gaitskell ◽  
Rafael Perera ◽  
Elizabeth J Soilleux
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Heart Weight ◽  
Gender And Age ◽  
Body Weights ◽  
Effect Of Age

As body weights and body mass indices have increased over time, we questioned the validity of correlating heart weight with body weight and whether tables from previous decades remain relevant. We investigated this by collecting details of heart weight, body weight, height, gender and age from 384 autopsy cases with no obvious heart or lung disease. Heart weights, body weights and heights showed a normal distribution for both genders. Heart weight correlated slightly better with body surface area than body weight and we present new reference charts derived from these data. The correlation between heart weight and body weight has changed little, despite increases in body weight and body mass index. As life expectancy is increasing, we investigated the effect of age on heart weight and demonstrated a small increase in heart weight relative to body surface area for both genders, in contrast to a previous study.

Contrast Enhancement in Cardiovascular MDCT: Effect of Body Weight, Height, Body Surface Area, Body Mass Index, and Obesity

2008 ◽  
Vol 190 (3) ◽  
pp. 777-784 ◽  
Author(s):  
Kyongtae T. Bae ◽  
Brian A. Seeck ◽  
Charles F. Hildebolt ◽  
Cheng Tao ◽  
Fang Zhu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Contrast Enhancement ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface

The use of Body Surface Index as a Better Clinical Health indicators Compare to Body Mass Index and Body Surface Area for Clinical Application

2018 ◽  
pp. 131-136
Author(s):  
Shirazu I. ◽  
Theophilus. A. Sackey ◽  
Elvis K. Tiburu ◽  
Mensah Y. B. ◽  
Forson A.
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Clinical Application ◽  
Body Surface ◽  
Body Height ◽  
Health Indicators ◽  
The Body ◽  
Body Parameters ◽  
The Relationship ◽  
Individual Body

The relationship between body height and body weight has been described by using various terms. Notable among them is the body mass index, body surface area, body shape index and body surface index. In clinical setting the first descriptive parameter is the BMI scale, which provides information about whether an individual body weight is proportionate to the body height. Since the development of BMI, two other body parameters have been developed in an attempt to determine the relationship between body height and weight. These are the body surface area (BSA) and body surface index (BSI). Generally, these body parameters are described as clinical health indicators that described how healthy an individual body response to the other internal organs. The aim of the study is to discuss the use of BSI as a better clinical health indicator for preclinical assessment of body-organ/tissue relationship. Hence organ health condition as against other body composition. In addition the study is `also to determine the best body parameter the best predict other parameters for clinical application. The model parameters are presented as; modeled height and weight; modelled BSI and BSA, BSI and BMI and modeled BSA and BMI. The models are presented as clinical application software for comfortable working process and designed as GUI and CAD for use in clinical application.

Body Mass Index and Body Surface Area and Their Associations with Outcomes in Stage II and III Colon Cancer

2012 ◽  
Vol 44 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Sina Alipour ◽  
Hagen F. Kennecke ◽  
Ryan Woods ◽  
Howard J. Lim ◽  
Caroline Speers ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Colon Cancer ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Stage Ii
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