Fatty liver is an independent risk factor for gallbladder polyps

Background: Non-alcoholic fatty liver disease (NAFLD) can increase the incidence of cardiovascular disease and hepatocellular carcinoma. Thyroid hormones also play important roles in hepatic lipid metabolism and hepatic insulin resistance. Hypothyroidism is associated with reduced lipolysis and decreased liver uptake of free fatty acids derived from triglycerides. In recent years, the correlation between overt or subclinical hypothyroidism and NAFLD has been discussed. The relationship between NAFLD and thyroid function parameters remains unclear. Aim: We aimed to evaluate the relationship between serum level of Thyroid Stimulating Hormone (TSH) within normal reference range and Non Alcoholic fatty liver Disease (NAFLD). Subjects and Methods: This is a cross sectional case control study on 40 patients with NAFLD and a control group of 20 healthy individuals, who were attendants of Outpatient Clinic of Internal Medicine Department of Tanta University Hospitals and EL-Menshawy General Hospital from February 2018 to the end of January 2019. Results: In the present study, univariate regression analysis showed that serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Conclusion: Serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD in univariate regression analysis, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Despite the positive correlation between serum TSH level and grade of NAFLD, the study didn’t show serum TSH level as independent risk factor of NAFLD.

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Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men

Atherosclerosis ◽

10.1016/j.atherosclerosis.2015.04.009 ◽

2015 ◽

Vol 240 (2) ◽

pp. 380-386 ◽

Cited By ~ 36

Author(s):

Kadir Ozturk ◽

Ahmet Uygun ◽

Ahmet Kerem Guler ◽

Hakan Demirci ◽

Cafer Ozdemir ◽

...

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Young Adult ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Nonalcoholic Fatty Liver ◽

Adult Men

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865 NONALCOHOLIC FATTY LIVER DISEASE IS AN INDEPENDENT RISK FACTOR FOR COLORECTAL NEOPLASIA IN CAUCASIANS

Journal of Hepatology ◽

10.1016/s0168-8278(11)60867-2 ◽

2011 ◽

Vol 54 ◽

pp. S345

Author(s):

A. Stadlmayr ◽

E. Aigner ◽

M. Strasser ◽

W. Patsch ◽

C. Datz

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Colorectal Neoplasia ◽

Nonalcoholic Fatty Liver

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OP-143 NON ALCOHOLIC FATTY LIVER DISEASE IS AN INDEPENDENT RISK FACTOR FOR PRESENCE OF CALCIUM IN CORONARY ARTERIES

International Journal of Cardiology ◽

10.1016/s0167-5273(12)70084-0 ◽

2012 ◽

Vol 155 ◽

pp. S32-S33

Author(s):

A.I. Atar ◽

Ö.Ç. Yilmaz ◽

K. Akin ◽

Y. Selçoki ◽

O. Er ◽

...

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Coronary Arteries ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Prevalence of Non-alcoholic Fatty Liver Disease among Patients with Diabetes Mellitus Attending Primary Health Care Centers in Bahrain

Oman Medical Journal ◽

10.5001/omj.2022.53 ◽

2021 ◽

Author(s):

Afaf Merza Mohamed ◽

Hasan Mohamed Ali Isa ◽

Mohamed Shaikh Ali ◽

Abdulhusain Dadi ◽

Zahra Kadhim

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Risk Factor ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Female Gender ◽

Alcoholic Fatty Liver ◽

Primary Health ◽

Alcoholic Fatty Liver Disease

Objectives: We aimed to identify the prevalence of non-alcoholic fatty liver disease (NAFLD) among patients with type-2 diabetes mellitus (T2DM) and to assess the possible risk factors. Methods: In this retrospective cross-sectional study, a random sample from patients receiving treatment for T2DM in the non-communicable disease clinic, primary health centers, Bahrain in 2018 was reviewed. Three-hundred eighty-two patients who underwent abdominal ultrasonography were selected for the study. Detailed patients’ data were collected and statistically analyzed. Prevalence of NAFLD and its’ possible risk factors were assessed. Results: The study populations were mostly females (235 (61.5%) patients). The mean age was 5912 years. Hypertension was the most frequent associated disease (221 (57.9%) patients). Most of the patients were either overweight or obese, 103 (30.5%) and 197 (58.3%), respectively. Elevated alanine aminotransferase (ALT) was found in 75 (21%) of 357 (93.5%) tested patients. Two-hundred sixty (68.06%) patients had fatty liver based on ultrasound imaging. In univariate analysis, female gender (p=0.013), high body mass index (BMI) (p<0.0001), high waist circumference (p=0.011) and high triglyceride levels (p=0.043) were significant risk factors for fatty liver. In binary logistic regression, BMI was the independent risk factor for fatty liver (p=0.005). Conclusions: The prevalence of NAFLD among patients with T2DM was found to be high. However, it was comparable to what has been reported in other studies. Female gender, high BMI, waist circumference and triglyceride level are risk factors for NAFLD. BMI is the independent risk factor.

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Increased Prevalence of Colorectal Adenomas in Patients with Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Digestive Diseases ◽

10.1159/000502684 ◽

2019 ◽

Vol 38 (3) ◽

pp. 222-230 ◽

Cited By ~ 2

Author(s):

John William Blackett ◽

Elizabeth C. Verna ◽

Benjamin Lebwohl

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Colorectal Adenomas ◽

Advanced Fibrosis ◽

Nonalcoholic Fatty Liver ◽

Adenoma Detection

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Previous studies have suggested an association between colorectal adenomas and NAFLD but are limited by a lack of biopsy-proven NAFLD or comparison with matched controls. Objectives: We aimed to determine whether histologically demonstrated NAFLD is an independent risk factor for colorectal adenomas. Methods: Patients who underwent liver biopsy showing steatosis who had also undergone screening or surveillance colonoscopy in 2007–2017 were retrospectively studied by manual chart review, excluding patients with liver disease other than NAFLD. Adenoma detection rates and characteristics such as location, histologic type, and size were compared in the resulting 123 NAFLD patients against controls without liver disease matched by age, gender, and endoscopist. Results: Adenoma prevalence was significantly higher in the NAFLD group at 40.7 versus 28.1% in controls (OR 1.87, 95% CI 1.15–3.03, p = 0.01) and remained significant on multivariable analysis controlling for rates of hyperlipidemia, diabetes, and obesity (OR 1.74, 95% CI 1.05–2.88, p = 0.032). Comparing NAFLD patients with advanced fibrosis to those with simple steatosis, there was a trend toward higher adenoma prevalence in advanced fibrosis (50.0 vs. 36.8%; OR 1.84, 95% CI 0.50–6.70, p = 0.36). Conclusions: Patients with histologically demonstrated NAFLD had a significantly higher adenoma prevalence on colonoscopy compared to matched controls, which remained significant after adjusting for rates of diabetes, obesity, and hyperlipidemia. NAFLD should be investigated further as an independent risk factor for colorectal neoplasia.

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