scholarly journals Prevalence of Non-alcoholic Fatty Liver Disease among Patients with Diabetes Mellitus Attending Primary Health Care Centers in Bahrain

2021 ◽  
Author(s):  
Afaf Merza Mohamed ◽  
Hasan Mohamed Ali Isa ◽  
Mohamed Shaikh Ali ◽  
Abdulhusain Dadi ◽  
Zahra Kadhim
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Risk Factor ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Female Gender ◽  
Alcoholic Fatty Liver ◽  
Primary Health ◽  
Alcoholic Fatty Liver Disease

Objectives: We aimed to identify the prevalence of non-alcoholic fatty liver disease (NAFLD) among patients with type-2 diabetes mellitus (T2DM) and to assess the possible risk factors. Methods: In this retrospective cross-sectional study, a random sample from patients receiving treatment for T2DM in the non-communicable disease clinic, primary health centers, Bahrain in 2018 was reviewed. Three-hundred eighty-two patients who underwent abdominal ultrasonography were selected for the study. Detailed patients’ data were collected and statistically analyzed. Prevalence of NAFLD and its’ possible risk factors were assessed. Results: The study populations were mostly females (235 (61.5%) patients). The mean age was 5912 years. Hypertension was the most frequent associated disease (221 (57.9%) patients). Most of the patients were either overweight or obese, 103 (30.5%) and 197 (58.3%), respectively. Elevated alanine aminotransferase (ALT) was found in 75 (21%) of 357 (93.5%) tested patients. Two-hundred sixty (68.06%) patients had fatty liver based on ultrasound imaging. In univariate analysis, female gender (p=0.013), high body mass index (BMI) (p<0.0001), high waist circumference (p=0.011) and high triglyceride levels (p=0.043) were significant risk factors for fatty liver. In binary logistic regression, BMI was the independent risk factor for fatty liver (p=0.005). Conclusions: The prevalence of NAFLD among patients with T2DM was found to be high. However, it was comparable to what has been reported in other studies. Female gender, high BMI, waist circumference and triglyceride level are risk factors for NAFLD. BMI is the independent risk factor.

11. Risk factors for development of diabetes mellitus in non-alcoholic fatty liver disease (NAFLD) patients

2018 ◽  
Vol 8 ◽  
pp. S39-S40
Author(s):  
Shivaram Prasad Singh ◽  
Saroj Kanta Sahu ◽  
Prasanta Kumar Parida ◽  
Sambit Kumar Behera ◽  
Suryakanta Parida ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Relationship of Non Alcoholic Fatty Liver Disease (NAFLD) and Serum Level of Thyroid Stimulating Hormone (TSH) in Normal Reference Range

2021 ◽  
pp. 33-39
Author(s):  
Doaa Ameen Khalil ◽  
Yasser Mohammed Abdul Raouf ◽  
Amal Said Al-Bendary ◽  
Kamal Mohamed Okasha
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Serum Level ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) can increase the incidence of cardiovascular disease and hepatocellular carcinoma. Thyroid hormones also play important roles in hepatic lipid metabolism and hepatic insulin resistance. Hypothyroidism is associated with reduced lipolysis and decreased liver uptake of free fatty acids derived from triglycerides. In recent years, the correlation between overt or subclinical hypothyroidism and NAFLD has been discussed. The relationship between NAFLD and thyroid function parameters remains unclear. Aim: We aimed to evaluate the relationship between serum level of Thyroid Stimulating Hormone (TSH) within normal reference range and Non Alcoholic fatty liver Disease (NAFLD). Subjects and Methods: This is a cross sectional case control study on 40 patients with NAFLD and a control group of 20 healthy individuals, who were attendants of Outpatient Clinic of Internal Medicine Department of Tanta University Hospitals and EL-Menshawy General Hospital from February 2018 to the end of January 2019. Results: In the present study, univariate regression analysis showed that serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Conclusion: Serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD in univariate regression analysis, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Despite the positive correlation between serum TSH level and grade of NAFLD, the study didn’t show serum TSH level as independent risk factor of NAFLD.

scholarly journals Thyroid‐stimulating hormone is an independent risk factor of non‐alcoholic fatty liver disease

JGH Open ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 400-404 ◽  
Author(s):  
Kazuki Tahara ◽  
Takemi Akahane ◽  
Tadashi Namisaki ◽  
Kei Moriya ◽  
Hideto Kawaratani ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Thyroid Stimulating Hormone ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Stimulating Hormone

scholarly journals Relationship Between BMI Degree and Non-Alcoholic Fatty Liver Disease Risk Factors

2021 ◽  
Vol 3 (1) ◽  
pp. 35-41
Author(s):  
Chairunnisa Fitri Marpaung ◽  
Gontar Alamsyah Siregar ◽  
Ilhamd
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Risk ◽  
Clinical Chemistry ◽  
Overweight And Obesity ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: Obesity is a major risk factor for cardiovascular disease, type 2 diabetes, high blood pressure, sleep apnea, psychological issues, some musculoskeletal conditions, and some cancers. The aim of the study to evaluate the correlation between BMI and risk factor of non-alcoholic fatty liver disease (NAFLD). Method: The research was conducted cross-sectionally in NAFLD patients who were treated at RSUP H Adam Malik Medan and got approval from the Ethics Commission for Health Research. Sample research is NAFLD patients who are taken in consecutive sampling that meets the criteria of inclusion and exclusion.  Body mass index (BMI) is obtained by dividing a person's weight in kilograms by their height in square meters, define obesity (OB) if BMI  >  25,  overweight  (OW) BMI  23-24.9, and normoweight (NW) BMI 18.5-22.9. Diagnose NAFLD by performing ultrasound examination, resistin and adiponectin examination with ELISA (Sandwich Immunoassay), liver function according to IFCC (International Federation of Clinical Chemistry), and albumin checked by BCG method. Result: There were 67 patients (NM=32, OW=15, OB=20) NAFLD with an average age of 42.1± 11.9 years,  Comparison of NAFLD risk factors in normoweight, overweight, and obesity, showing very significant results (all p<0.001). There is a very significant correlation between BMI and all NAFLD risk factors (all p<0.001). Conclusion: There are very significant correlates between BMI and all inflammatory factors of NAFLD.

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