scholarly journals Evaluation of Serum Hepcidin Level in Iraqi Patients with Chronic Hepatitis C and Relation to Serum Iron Status

2021 ◽  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Iron ◽  
Iron Status ◽  
Hepcidin Level ◽  
Serum Hepcidin

scholarly journals Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels

BioMedica ◽  
2020 ◽  
Vol 36 (3) ◽  
pp. 259-264
Author(s):  
Maria Gill ◽  
Javaria Sharafat ◽  
Muhammad Usman Bashir ◽  
Rozina Noreen Hashmi ◽  
Khalid Pervez Lone ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Iron ◽  
Serum Hepcidin ◽  
Chronic Hepatitis C Patients

Role of hepcidin as a biomarker for iron status and its effect on anemia management in patients with chronic kidney disease (stage II-Iv) after HCV treatment

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy M El Sharkawy ◽  
Lina E Khedr ◽  
Ashraf H Abdelmbdy ◽  
Mohamed T Mohamed
Keyword(s):  
Chronic Kidney Disease ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Iron Status ◽  
Disease Stage ◽  
Hepcidin Level ◽  
Stage 4 ◽  
Ckd Stage ◽  
Serum Hepcidin

Abstract Background Anemia is a severe complication of chronic kidney disease (CKD) that is seen in more than 80% of patients with impaired renal function. Although there are many mechanisms involved in the pathogenesis of anemia of renal disease, the primary cause is the inadequate production of erythropoietin by the damaged kidneys. Aim of the work to assess hepcidin level in non dialysis patients (CKD stage 4 &5) treated from Hepatitis C virus and its relation to iron parameters. Patients and Methods This study was conducted on 20 CKD patients (stage 4 and 5) treated from hepatitis C virus. All candidates included in this study subjected to careful history taking, full clinical examination and investigations (including complete blood count, renal chemistry, HCVAb, serum iron, total iron binding capacity, TSAT%, ferritin and hsCRP. Serum hepcidin was analyzed by ELISA technique. Results Serum hepcidin was 26.35±7.26; 40% in stage III, 37.8% in stage IV and 22.2% in stage V. There was statistically significant difference between GFR stages according to Hb., Drug intake ACE inhibitor/ARB, Plt., Creatinine, BUN, Iron, TIBC, Ferritin, T SAT%, CRP and Serum Hepcidin. We showed significant correlations between serum hepcidin and TIC, Iron, TIBC, Ferritin and TSAT%. Conclusion Median hepcidin value is elevated in nondialysis CKD patients due to increased inflammation and decreased clearance of hepcidin. Furthermore, iron status modifies serum hepcidin level and its association with Hb. Increased hepcidin level leads to iron-restricted erythropoiesis and recombinant human EPO (rhEPO) resistance by inhibiting iron absorption from gut and iron recycling from macrophages. Hence, elevated hepcidin can predict need for parenteral iron to overcome hepcidin-mediated iron-restricted erythropoiesis and need for relatively higher rhEPO doses to suppress hepcidin.

scholarly journals Reduced serum hepcidin levels in patients with chronic hepatitis C

2009 ◽  
Vol 51 (5) ◽  
pp. 845-852 ◽  
Author(s):  
Domenico Girelli ◽  
Michela Pasino ◽  
Julia B. Goodnough ◽  
Elizabeta Nemeth ◽  
Maria Guido ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Hepcidin

Serum iron indices as a measure of iron deposits in chronic hepatitis C

2001 ◽  
Vol 304 (1-2) ◽  
pp. 49-55 ◽  
Author(s):  
Carlo Fabris ◽  
Pierluigi Toniutto ◽  
Cathryn A. Scott ◽  
Edmondo Falleti ◽  
Claudio Avellini ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Iron ◽  
Iron Deposits

scholarly journals Importance of studying the levels of hepcidin and vitamin D in Egyptian children with chronic hepatitis C

2019 ◽  
Vol 7 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Amal Ahmed Mohamed ◽  
Eman R. Abd Almonaem ◽  
Amira I. Mansour ◽  
HebatAllah Fadel Algebaly ◽  
Rania Abdelmonem Khattab ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Iron Metabolism ◽  
Hcv Infection ◽  
Vitamin D Levels ◽  
Egyptian Children ◽  
Serum Hepcidin

Abstract Background and Objective Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infection. This study assessed the level of vitamin D and serum hepcidin and its expression in peripheral blood of children with chronic hepatitis C (CHC) and correlated them with other serum markers to reflect iron metabolism and liver disease severity. Methods A total of 100 children were included in this study: 50 with HCV infection and 50 healthy controls. Biochemical parameters together with vitamin D, hepcidin, and its expression were all measured. Results The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (P<0.001). Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = −0.37). Both hepcidin and ferritin were higher in patients with Child Pugh scores B and C than those with score A (P<0.001). Conclusion Measuring serum hepcidin and its expression together with vitamin D levels in patients may have a prognostic value and is promising in the follow-up of the severity of liver disease.

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