A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues
2012 ◽
Vol 8
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pp. 1344-1351
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Keyword(s):
The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach. Alternative methods of macrolactonization (e.g., Corey–Nicolaou) resulted in significant epimerization of the C-terminal amino acid during the cyclization reaction. The D-stereochemistry of the alanine residue in the naturally occurring cyclic peptide may be required for the antifungal activity of this natural product.
1996 ◽
Vol 48
(6)
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pp. 417-432
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Keyword(s):
1993 ◽
Vol 51
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pp. 388-389
Keyword(s):
1974 ◽
Vol 39
(7)
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pp. 1933-1939
Keyword(s):
1980 ◽
Vol 45
(4)
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pp. 1144-1154
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Keyword(s):
1991 ◽
Vol 266
(11)
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pp. 7044-7050
Keyword(s):
1976 ◽
Vol 251
(14)
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pp. 4365-4371
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1984 ◽
Vol 259
(23)
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pp. 14928-14934
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Keyword(s):