scholarly journals A protocol for systematic review and network meta-analysis Efficacy and Safety of Kunxian Capsule in Treating Patients with Lupus Nephritis：A network meta-analysis

2021 ◽  
Author(s):  
Zifeng Li ◽  
◽  
Yuling Fan ◽  
Yunhong Lei ◽  
Xiaoqiang Hou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Lupus Nephritis ◽  
Immune Status ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Review Question

Review question / Objective: To study on the efficacy and safety of Kunxian Capsule in treating patients with lupus nephritis( LN). Condition being studied: The study showed that Kunxian capsule significantly improved immune status and renal function and suppressed IL-10 and TNF in serum of lupus mice- α Of secretion, works better in combination with and reduces hormone dosage. At present, there are few studies in which Kunxian capsules are used in the clinic, and the conclusions of the studies are inconsistent, so this study was conducted in order to comprehensively evaluate the efficacy and safety of Kunxian capsules for the treatment of lupus nephritis.

scholarly journals The Efficacy and Safety of Leflunomide for the Treatment of Lupus Nephritis in Chinese Patients: Systematic Review and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144548 ◽  
Author(s):  
Heng Cao ◽  
Yuefeng Rao ◽  
Lin Liu ◽  
Jin Lin ◽  
Hongyu Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lupus Nephritis ◽  
Meta Analysis ◽  
Chinese Patients ◽  
Efficacy And Safety

scholarly journals Therapeutic effect and safety of Tuina on Sciatica: A protocol for systematic review and meta-analysis

2021 ◽  
Author(s):  
Huixin Yan ◽  
◽  
Yun An ◽  
Tao Zhao ◽  
Jiangna Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Leg Pain ◽  
Efficacy And Safety ◽  
Scientific Issue ◽  
Review Question ◽  
The Common ◽  
Pain Symptoms ◽  
Tuina Therapy

Review question / Objective: This study aimed to conduct a meta-analysis of Tuina in the treatment of Sciatica to clarify its efficacy and safety. Condition being studied: Sciatica is one of the common pain symptoms in the human body, also known as radiating leg pain. Sciatica is increasingly occurring due to poor posture and lack of physical exercise all over the world. At present, many studies have indicated that Tuina can improve the clinical symptoms and functional status of sciatica. However, there is currently no relevant systematic review to evaluate and report this clinical scientific issue. Consequently, this study will conduct a meta-analysis on the effectiveness and safety of Tuina therapy for sciatica.

scholarly journals Clinical efficacy and safety outcomes of bempedoic acid for LDL-C lowering therapy in patients at high cardiovascular risk: a systematic review and meta-analysis

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
Y Lin ◽  
C Parco ◽  
A Karathanos ◽  
T Krieger ◽  
V Schulze ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
High Cardiovascular Risk ◽  
Muscular Disorders ◽  
Risk Patients

Abstract Background Bempedoic acid (BA) is a novel oral low-density lipoprotein cholestrol (LDL-C) lowering drug. Its efficacy and safety for clinical outcomes in high cardiovascular risk patients remains unknown. Objectives and methods A systematic review was performed and randomized controlled trials (RCTs) of BA vs. placebo in high cardiovascular risk patients reporting clinical efficacy and safety outcomes were included in a meta-analysis. Cumulative odds ratios (OR) and mean differences with 95% confidence intervals (CI) were reported as summary statistics. Results Six RCTs with a total of 3,956 patients and follow-ups of four to 52 weeks were identified. There was no difference in MACE (OR 0.84; CI 0.61, 1.15), all-cause mortality (OR 2.37; CI 0.80, 6.99) and cardiovascular mortality (OR 1.66; CI 0.45, 6.04) for BA vs. placebo. BA showed beneficial trends for nonfatal myocardial infarction (OR 0.57; CI 0.32, 1.00) and was associated with a lower risk of new-onset or worsening of diabetes mellitus (OR 0.68; CI 0.49, 0.94) and non-coronary revascularization (OR 0.41; CI 0.18, 0.95), but higher risk of gout (OR 3.29; CI 1.28, 8.46) and a trend for worsening of renal function (OR 4.24; CI 0.98, 18.39) and muscular disorders (OR 2.60; CI 1.15, 5.91). Conclusion Bempedoic acid in high cardiovascular risk patients showed no significant effects on major cardiovascular outcomes in short-term follow-up. Unfavourable effects on muscular disorders, renal function and the incidence of gout sound a note of caution. Hence, further studies with longer-term follow-up are needed to clarify the risk/benefit ratio of this novel therapy. Funding Acknowledgement Type of funding sources: None.

scholarly journals Laparoscopic Versus Conventional Open Treatment of Liver Hydatid: A Systematic Review and Meta-analysis of Cohort Studies

2022 ◽  
Author(s):  
Zheng Wang ◽  
◽  
Hai-Hong Zhu ◽  
Jin-Yu Yang ◽  
Yan Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Minimally Invasive ◽  
Open Surgery ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Advantages And Disadvantages ◽  
Open Treatment ◽  
Review Question ◽  
Hepatic Echinococcosis

Review question / Objective: With the popularity of laparoscopy and minimally invasive technology, laparoscopy has been applied to hepatic echinococcosis. However, the safety and efficacy of traditional laparotomy and laparoscopy are unclear. This study aimed to explore the advantages and disadvantages of laparoscopy and traditional laparotomy with a Meta-analysis.To compare the efficacy and safety of laparoscopic with that of traditional laparotomy. Condition being studied: There still exist controversies about the advantages and disadvantages of laparoscopic and traditional open surgery.

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