scholarly journals Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

10.3791/55537 ◽  
2017 ◽  
Author(s):  
Pedro Brugarolas ◽  
Mohammed Bhuiyan ◽  
Anna Kucharski ◽  
Richard Freifelder
Keyword(s):  
Demyelinating Diseases ◽  
Pet Tracer ◽  
Radiochemical Synthesis

scholarly journals Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS

2021 ◽  
Vol 12 (4) ◽  
pp. 756-765
Author(s):  
Nicolas J. Guehl ◽  
Ramesh Neelamegam ◽  
Yu-Peng Zhou ◽  
Sung-Hyun Moon ◽  
Maeva Dhaynaut ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Pet Tracer ◽  
Radiochemical Synthesis

scholarly journals Detecting Demyelination by PET: The Lesion as Imaging Target

2018 ◽  
Vol 17 ◽  
pp. 153601211878547 ◽  
Author(s):  
Pedro Brugarolas ◽  
Daniel S. Reich ◽  
Brian Popko
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Quantitative Measure ◽  
Demyelinating Diseases ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Voltage Gated ◽  
Pet Tracer ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al’s study 1 , we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.

The Influence of Polysorbate 80 on the Radiochemical Synthesis of a PET Tracer in the FASTlab

2014 ◽  
Vol 32 (4) ◽  
pp. 1425-1437
Author(s):  
Wai Lam Yip ◽  
Sverre Arne Sande ◽  
David Grace ◽  
Dirk Jan in’t Veld ◽  
Per Christian Sontum ◽  
...  
Keyword(s):  
Polysorbate 80 ◽  
Pet Tracer ◽  
Radiochemical Synthesis

Comparison of diagnostic accuracy of 18F-FDG PET, 123I-IMT- and 99mTc-MIBI SPECT

2006 ◽  
Vol 45 (01) ◽  
pp. 49-56 ◽  
Author(s):  
N. Özdemir-Sahin ◽  
P. Hipp ◽  
W. Mier ◽  
M. Eisenhut ◽  
J. Debus ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Fdg Pet ◽  
Tumour Progression ◽  
Roc Curves ◽  
Low Grade ◽  
Who Grade ◽  
Pet Tracer ◽  
Patient Groups ◽  
99Mtc Mibi ◽  
Mibi Spect

Summary Aim was to evaluates the diagnostic accuracy of the SPECTtracers 3-123I-α-methyl-L-tyrosine (IMT) and 99mTc(I)- hexakis(2-methoxyisobutylisonitrile) (MIBI) as well as the PET-tracer 2-18F-2-deoxyglucose (FDG) for detecting tumour progression in irradiated low grade astrocytomas (LGA). Patients, methods: We examined 91 patients (56 males; 35 females; 44.7 ± 11.5 years), initially suffering from histologically proven LGAs (mean WHO grade II) and treated by stereotactic radiotherapy (59.0 ± 4.6 Gy). On average 21.9 ± 11.2 months after radiotherapy, patients presented new Gd-DTPA enhancing lesions on MRI, which did not allow a differentiation between progressive tumour (PT) and non-PT (nPT) at this point of time. PET scans (n=82) were acquired 45 min after injection of 208 ± 32 MBq FDG. SPECT scans started 10 min after injection of 269 ± 73 MBq IMT (n=68) and 15 min after injection of 706 ± 63 MBq MIBI (n=34). Lesions were classified as PT and nPT based on prospective follow-up (clinically, MRI) for 17.2 ± 9.9 months after PET/SPECT. Lesion-to-normal ratios (L/N) were calculated using contra lateraly mirrored reference regions for the SPECT examinations and reference regions in the contra lateral grey (GM) and white matter (WM) for FDG PET. Ratios were evaluated by Receiver Operating Characteristic (ROC) analysis. Results: In the patient groups nPT and PT, L/N ratios for FDG (GS) were 0.6 ± 0.3 vs. 1.2 ± 0.5 (p = 0.003), for FDG (WS) 1.2 ± 0.4 vs. 2.6 ± 0.4 (p <0.001), for IMT 1.1 ± 0.1 vs. 1.8 ± 0.4 (p <0.001) and for MIBI 1.6 ± 0.7 vs. 2.6 ± 2.2 (p = 0.554). Areas under the non-parametric ROC-curves were: 0.738 ± 0.059 for FDG (GS), 0.790 ± 0.057 for FDG (WS), 0.937 ± 0.037 for IMT and 0.564 ± 0.105 for MIBI. Conclusion: MIBI-SPECT examinations resulted in a low accuracy and especially in a poor sensitivity even at modest specificity values. A satisfying diagnostic accuracy was reached with FDG PET. Using WM as reference region for FDG PET, a slightly higher AUC as compared to GM was calculated. IMT yielded the best ROC characteristics and the highest diagnostic accuracy for differentiating between PT and nPT in irradiated LGA.

Klinischer Nutzen nuklearmedizinischer Verfahren in der Demenzdiagnostik

2009 ◽  
Vol 28 (10) ◽  
pp. 709-717
Author(s):  
A. Drzezga
Keyword(s):  
Post Mortem ◽  
Klinischer Nutzen ◽  
Pet Tracer

ZusammenfassungEine sichere Diagnose neurodegenerativer Demenzerkrankungen kann nur mittels post mortem histopathologischer Evaluation des Gehirngewebes erfolgen. Es ist akzeptiert, dass die pathologischen Veränderungen Jahre bis Jahrzehnte vor Beginn der klinischen Symptomatik einsetzen. Der Nutzen klinischneuropsychologischer Maße für die frühe Diagnostik dieser Erkrankungen im vor- oder geringsymptomatischen Stadium ist somit limitiert. Die zum Teil deutliche symptomatische Überlappung unterschiedlicher Demenzerkrankungen erschwert zusätzlich die klinische Differenzialdiagnostik. Insbesondere neue Therapieansätze machen aber eine frühe und zuverlässige Differenzialdiagnose immer wichtiger, was den Bedarf an geeigneten Biomarkern unterstreicht. Hier sollen zwei Verfahren der molekularen und funktionellen Bildgebung behandelt werden, die vielversprechend und gut evaluiert sind: Die FDGPET (Positronen Emissions Tomografie) als Marker der regionalen neuronalen Dysfunktion. Und die Amyloidplaquebildgebung mittels moderner PET-Tracer wie dem PIB. Deren Wertigkeit in der Früh- und Differenzialdiagnostik sowie für die Patientenselektion für Therapiestudien und für eine objektive Therapiekontrolle wird diskutiert.

Revolutionary Advances in the Prevention of Demyelinating Diseases

2009 ◽  
Vol 28 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Richard Edlich ◽  
Shelley S. Mason ◽  
Margot E. Chase ◽  
Allyson L. Fisher ◽  
K. Dean Gubler ◽  
...  
Keyword(s):  
Demyelinating Diseases

Comparison of 18F-FDG and 67Ga-citrate in sarcoidosis imaging

2008 ◽  
Vol 47 (01) ◽  
pp. 18-23 ◽  
Author(s):  
M. Wehrschuetz ◽  
B. Bisail ◽  
M. Woltsche ◽  
T. Schwarz ◽  
H. Lanz ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Complete Agreement ◽  
Pet Tracer ◽  
Positron Emission ◽  
Significant Difference ◽  
Kappa Value ◽  
18F Fdg ◽  
Primary Assessment ◽  
67Ga Citrate

SummaryAim: 67Ga citrate has been used long and successfully to diagnose and stage sarcoidosis. 18F-fluorodeoxyglucose (18F-FDG) has been suggested as a positron emission tomography (PET) tracer for sarcoidosis imaging. This study aimed to analyze possible advantages of 18F-FDG-PET over 67Ga citrate scintigraphy during the primary assessment of patients with sarcoidosis. Patients and methods: Twentyfour patients (11 men, 13 women, aged 52 years ±12.4) with histologically proven sarcoidosis were investigated with 18F-FDG and 67Ga citrate. Equipment included a fullring PET scanner (ECAT EXACT HR+, Siemens/CTI, Knoxville TN, USA) and a double-headed gamma camera (ECAM, Siemens, Illinois, USA) for scintigraphy. The mean time difference between the two studies was 6.5 days (range: 5–8 days). Results: There was a significant difference in the detection of pulmonary and nonpulmonary sarcoidosis lesions between planar 67Ga citrate scans and 18F-FDG-PET images (<0.0021). A total of 64 lesions were detected with 67Ga citrate scans in the thorax and elsewhere with a mean of 2.6 lesions (4%) per patient, while 85 lesions were found with 18F-FDG-PET, with a mean of 3.5 lesions (4.1%) per patient. There was complete agreement between 18F-FDG and 67Ga citrate in thoracic manifestations in four (16.6%) patients, and in non-thoracic manifestations in five (20.8%) patients. The interobserver variability showed a kappa value of 0.79. Conclusion: 67Ga citrate and 18F-FDG are useful tracers for diagnostic evaluation of thoracic sarcoidosis. 18F-FDG seems to be more suitable for imaging the mediastinum, the bi-hilar lymph nodes, the posterior regions of the lungs and non-thoracic lesions. Further prospective studies are needed to clarify the role of both tracers in early diagnosis and staging of sarcoidosis, and to resolve questions concerning medical treatment and follow-up.

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