Retraction: Clinical Characteristics of Poorly Differentiated Carcinoma of the Thyroid and Comparison of Survival to Tall Cell and Columnar Cell Variants of the Papillary Carcinoma

2006 ◽  
Vol 21 (6) ◽  
pp. 589
Author(s):  
Tae Sik Jung ◽  
Jae Hoon Chung ◽  
Young Lyun Oh ◽  
Tae Yong Kim ◽  
Young Kee Shong ◽  
...  
2016 ◽  
Vol 70 (2) ◽  
pp. 116-119 ◽  
Author(s):  
Heather K Schopper ◽  
Aaron Stence ◽  
Deqin Ma ◽  
Nitin A Pagedar ◽  
Robert A Robinson

AimsA 49-year-old man presented with a single thyroid tumour that showed a combination of conventional papillary carcinoma, follicular variant of papillary carcinoma, clear cell papillary carcinoma, columnar cell carcinoma and poorly differentiated carcinoma. As all of the morphologies have been associated with papillary carcinoma in the literature, we wished to determine if they contained identical or different molecular abnormalities.MethodsTargeted next generation sequencing (NGS) of each morphological component and metastases was performed.ResultsNGS revealed a BRAF p.K601E mutation in both the clear cell papillary carcinoma and poorly differentiated carcinoma and a KRAS p.G12R mutation in the papillary carcinoma, follicular variant. Two different areas of columnar cell variant were tested, with one showing a KRAS p.G12D mutation but no mutation in the other area. A KRAS p.G12R mutation was seen in the metastatic clear cell variant. Two different lymph nodes had metastatic columnar cell carcinoma, one negative for mutations but the other with a compound KRAS p.G12R and KRAS p.G12V mutation on different alleles. No mutations including BRAF and KRAS were seen in the conventional papillary carcinoma.ConclusionsAlthough all of the morphological patterns in this tumour have been reported as having aetiological or other association with one another, there was only partial concordance with their molecular signatures. There was significant molecular discordance, however, even with identical morphologies.


2015 ◽  
Vol 26 ◽  
pp. vii86
Author(s):  
Makoto Kodaira ◽  
Tatsunori Shimoi ◽  
Jun Hashimoto ◽  
Harukaze Yamamoto ◽  
Mayu Yunokawa ◽  
...  

Author(s):  
Marcos Tadashi Kakitani Toyoshima ◽  
Regina Barros Domingues ◽  
Ibere Cauduro Soares ◽  
Debora Lucia Seguro Danilovic ◽  
Larissa Costa Amorim ◽  
...  

2021 ◽  
Vol 15 (1) ◽  
pp. 77-81
Author(s):  
Mahwish Niaz ◽  

Background: Thyroid cancer is the leading cause of death both in developing and developed countries. Patients present with enlarged thyroid. Radiology shows hot and cold nodules. Thyroidectomy or lobectomy is done to rule out malignancy. Objective: To determine the incidence of thyroid carcinomas and other pathologies in thyroidectomy specimen of different age group patients presenting with clinically enlarged thyroid. Study Design: Cross-sectional study. Settings: Department of Histopathology, Foundation University Medical College (FUMC), Islamabad and Department of surgery, Fauji Foundation Hospital (FFH), Rawalpindi Pakistan. Duration: from Jan 2012 to March 2019. Methodology: All the thyroidectomies specimens send from Surgery department of FFH to Histopathology Department of FUMC during study period and fulfilling the pre-set criteria were included in the study. All the data and results were analyzed using SPSS version 17.0. Results: Out of 500 total patients, 89% (n=445) were diagnosed as having multinodular goiter, 2.6% (n=13) thyroiditis, 2.2% (n=11) follicular adenoma, 0.8% (n=4) Hurthle cell adenoma, 0.2%(n=1) hyalinizing trabacular adenoma and thyroid carcinomas. The carcinomas comprised 2.6%(n=13) papillary carcinoma, 0.8%(n=4) poorly differentiated carcinoma,0.8%(n=4) anaplastic carcinoma,0.6%(n=3) medullary carcinoma and 0.4%(n=2) follicular carcinoma. In 445 patients of multinodular goiter 158 patients were in the age range of 41-50 years, in 13 cases of thyroiditis 7 were in the age range of 31-40 years, in 11 cases of follicular adenoma 4 patients were in the age range of 31-40 years, in 4 cases of hurthle cell adenoma 3 patients were in the age range of 41-50 years, in 13 cases of papillary thyroid carcinoma 5 patients were in the age range of 31-40 years, in 4 cases of poorly differentiated carcinoma 2 patients were in the age range of 41-50 years and in 4 cases of anaplastic carcinoma 2 patients were in the age range of 61-70 years. Conclusion: The study concluded that thyroid carcinomas collectively constituted 5.20% of the study cases. Papillary carcinoma was the most frequent malignant neoplasm constituting 2.6 % and occurring mostly in the age range of 31-40 years, while anaplastic carcinoma comprised of 0.8% of malignant lesions occurring in the age range of 61-70 years. The most frequent cause of thyroid enlargement was multinodular goiter (89%) with majority of the patients in the age range of 41-50 years.


1993 ◽  
Vol 102 (5) ◽  
pp. 402-403 ◽  
Author(s):  
M. John Hicks ◽  
John G. Batsakis

Tall cell carcinoma of the thyroid gland is an aggressive variant of papillary carcinoma with a respectable 20% to 25% lethality. Its histologic features are characterized by a basal orientation of nuclei, abundant eosinophilic or oxyphilic cytoplasm, and a cellular height-width ratio greater than 2:1. These distinguish it from another aggressive variant, columnar cell carcinoma, which has a stratification of its nuclei and scant cellular cytoplasm.


1988 ◽  
Vol 89 (2) ◽  
pp. 264-267 ◽  
Author(s):  
Manuel Sobrinho-Simões ◽  
Jahn M. Nesland ◽  
Jan Vincents Johannessen

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