A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats

Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT), a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity test in Crl:CD Sprague Dawley rats. BJIGT was orally administered in daily doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks via oral gavage in male and female rats. We examined the mortality, clinical signs, body weight change, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters. No significant changes were observed in mortality, clinical sings, body weight, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters between the control group and the BJIGT-treated groups in the rats of both sexes. The results indicate that BJIGT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. Thus, this concentration is considered the nonobservable effect dose in rats and is appropriate for a 13-week subchronic toxicity study.

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N-vinylpyrrolidone dimer (VPD), a novel excipient for oral drugs: Repeat-dose oral toxicity in Sprague–Dawley rats

Toxicology Letters ◽

10.1016/j.toxlet.2012.02.002 ◽

2012 ◽

Vol 210 (3) ◽

pp. 324-331 ◽

Cited By ~ 4

Author(s):

S. Weber ◽

S. Halm ◽

M. Du Vall ◽

K. Whitney ◽

G. Blaich ◽

...

Keyword(s):

Repeat Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Oral Drugs ◽

Sprague Dawley Rats ◽

Dose Oral

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200 Repeated dose oral toxicity (13 weeks) of 4-hydroxy-3-methoxy-benzaldehyde (vanillin) to sprague dawley rats

Toxicology Letters ◽

10.1016/s0378-4274(03)90199-8 ◽

2003 ◽

Vol 144 ◽

pp. s57 ◽

Cited By ~ 3

Author(s):

Axel Mancebo ◽

Yoagne M. Trapero ◽

Yana González ◽

Bárbara O. Gonzalez ◽

Dasha Fuentes ◽

...

Keyword(s):

Repeated Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Dose Oral

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A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats

Korean Journal of Plant Resources ◽

10.7732/kjpr.2015.28.4.371 ◽

2015 ◽

Vol 28 (4) ◽

pp. 371-381

Author(s):

Min-Kyeoung Kim ◽

Ji Sun Lee ◽

Yeong Chul Park ◽

Sun Mi Choi ◽

Sanghun Lee

Keyword(s):

Repeated Dose ◽

Aqueous Extracts ◽

Sprague Dawley ◽

Oral Toxicity ◽

Toxicity Studies ◽

Sprague Dawley Rats ◽

Dose Oral

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A 14-day Repeated Dose Oral Toxicity Study of HT042 in Sprague-Dawley Rats

The Korea Journal of Herbology ◽

10.6116/kjh.2017.32.1.63. ◽

2017 ◽

Vol 32 (1) ◽

pp. 63-68

Author(s):

Jungbin Song ◽

Donghun Lee ◽

Young-Sik Kim ◽

Seunggyeong Lee ◽

Jin-Sook Bae ◽

...

Keyword(s):

Toxicity Study ◽

Repeated Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Dose Oral

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Evaluation of 90-day Repeated Dose Oral Toxicity, Glycometabolism, Learning and Memory Ability, and Related Enzyme of Chromium Malate Supplementation in Sprague-Dawley Rats

Biological Trace Element Research ◽

10.1007/s12011-015-0341-4 ◽

2015 ◽

Vol 168 (1) ◽

pp. 181-195 ◽

Cited By ~ 4

Author(s):

Weiwei Feng ◽

Huiyu Wu ◽

Qian Li ◽

Zhaoxiang Zhou ◽

Yao Chen ◽

...

Keyword(s):

Learning And Memory ◽

Repeated Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Memory Ability ◽

Sprague Dawley Rats ◽

Dose Oral ◽

Related Enzyme ◽

Chromium Malate

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Single- and Repeated-Dose Oral Toxicity Studies of Citicoline Free-Base (Choline Cytidine 5′-Pyrophosphate) in Sprague-Dawley Rats

International Journal of Toxicology ◽

10.1177/1091581809349452 ◽

2009 ◽

Vol 28 (6) ◽

pp. 479-487 ◽

Cited By ~ 11

Author(s):

A. G. Schauss ◽

S. Somfai-Relle ◽

I. Financsek ◽

R. Glavits ◽

S. C. Parent ◽

...

Keyword(s):

Urine Volume ◽

Free Base ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Dose Oral ◽

Absolute Lymphocyte Counts ◽

Renal Tubular ◽

High Level ◽

Phosphorus Intake

The dietary supplement Citicoline free-base (choline cytidine 5′-pyrophosphate) was toxicologically evaluated in Sprague-Dawley rats using oral gavage. In an acute 14-day study, 2000 mg/kg was well tolerated. In a 90-day study, 100, 350, and 1000 mg/kg/day doses resulted in no mortality. In males, slight significant increases in serum creatinine (350 and 1000 mg/kg/day), and decreases in urine volume (all treated groups) were observed. In females, slight significant increases in total white blood cell and absolute lymphocyte counts (1000 mg/kg/day), and blood urea nitrogen (BUN) (100 and 350, but not 1000 mg/kg/day) were noted. A dose-related increase in renal tubular mineralization, without degenerative or inflammatory reaction, was found in females (all treated groups) and two males (1000 mg/kg/day). Renal mineralization in rats (especially females) is influenced by calcium:phosphorus ratios in the diet. A high level of citicoline consumption resulted in increased phosphorus intake in the rats, and likely explains this result.

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