Novel Chemical Ion Source for a High-Field Asymmetric Waveform Ion Mobility Spectrometer Used under Ambient Conditions

A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H2O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS.

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Ion trapping at atmospheric pressure (760 Torr) and room temperature with a high-field asymmetric waveform ion mobility spectrometer

International Journal of Mass Spectrometry ◽

10.1016/s1387-3806(99)00148-7 ◽

1999 ◽

Vol 193 (1) ◽

pp. 45-56 ◽

Cited By ~ 38

Author(s):

Roger Guevremont ◽

Randy W. Purves ◽

David A. Barnett ◽

Luyi Ding

Keyword(s):

Ion Mobility ◽

Atmospheric Pressure ◽

High Field ◽

Room Temperature ◽

Ion Trapping ◽

Asymmetric Waveform ◽

Ion Mobility Spectrometer

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A novel micromachined high-field asymmetric waveform-ion mobility spectrometer

Sensors and Actuators B Chemical ◽

10.1016/s0925-4005(00)00535-9 ◽

2000 ◽

Vol 67 (3) ◽

pp. 300-306 ◽

Cited By ~ 103

Author(s):

R.A Miller ◽

G.A Eiceman ◽

E.G Nazarov ◽

A.T King

Keyword(s):

Ion Mobility ◽

High Field ◽

Asymmetric Waveform ◽

Ion Mobility Spectrometer

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Corona Discharge Ionization Source for a Planar High-Field Asymmetric Waveform Ion Mobility Spectrometer

Analytical Letters ◽

10.1080/00032719.2012.725190 ◽

2013 ◽

Vol 46 (3) ◽

pp. 452-460 ◽

Cited By ~ 4

Author(s):

Dongjie Zhao ◽

Jian Jia ◽

Jianping Li ◽

Junjian Li ◽

Xiaoguang Gao ◽

...

Keyword(s):

Corona Discharge ◽

Ion Mobility ◽

High Field ◽

Asymmetric Waveform ◽

Ionization Source ◽

Ion Mobility Spectrometer

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Comparison of Rectangular and Bisinusoidal Waveforms in a Miniature Planar High-Field Asymmetric Waveform Ion Mobility Spectrometer

Analytical Chemistry ◽

10.1021/ac200948b ◽

2011 ◽

Vol 83 (24) ◽

pp. 9237-9243 ◽

Cited By ~ 9

Author(s):

Marilyn Prieto ◽

Chia-Wei Tsai ◽

Said Boumsellek ◽

Robert Ferran ◽

Ilya Kaminsky ◽

...

Keyword(s):

Ion Mobility ◽

High Field ◽

Asymmetric Waveform ◽

Ion Mobility Spectrometer

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High Performance Micromachined Planar Field-Asymmetric Ion Mobility Spectrometers for Chemical and Biological Compound Detection

MRS Proceedings ◽

10.1557/proc-729-u4.1 ◽

2002 ◽

Vol 729 ◽

Cited By ~ 3

Author(s):

Raanan A. Miller ◽

Angela Zapata ◽

Erkinjon G. Nazarov ◽

Evgeny Krylov ◽

Gary A. Eiceman

Keyword(s):

Ion Mobility ◽

Medical Diagnosis ◽

High Field ◽

High Performance ◽

High Sensitivity ◽

Asymmetric Waveform ◽

Ion Mobility Spectrometer ◽

Non Invasive ◽

Sensing Applications ◽

Xylene Isomers

AbstractThe micromachined Planar High Field Asymmetric Waveform Ion Mobility Spectrometer (PFAIMS) is a novel detector for chemical and biological sensing applications. This detector fills an unmet market need, providing spectrometer capabilities and extremely high sensitivity, at a cost comparable to stand-alone sensors. The PFAIMS is quantitative, and has detection limits down to the parts-per-trillion. The performance of the PFAIMS in a number of applications ranging from industrial to biomedical, where it is used as both a stand alone sensor, and as a gas chromatographic detector are demonstrated. These applications include the detection of xylene isomers and non-invasive medical diagnosis through breath analysis.

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