scholarly journals Using Patch Testing to Improve Therapeutic Outcome in the Treatment of Hand Eczema in Vietnamese Patients

2019 ◽  
Vol 7 (2) ◽  
pp. 204-207 ◽  
Author(s):  
Phuong Pham Thi Minh ◽  
Trang Thi Minh ◽  
Doanh Le Huu ◽  
Thuong Nguyen Van ◽  
Sau Nguyen Huu ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Clinical Features ◽  
Potassium Dichromate ◽  
Nickel Sulfate ◽  
Hand Eczema ◽  
Test Reaction ◽  
Positive Patch Test ◽  
Causative Agents ◽  
Allergic Contact

BACKGROUND: Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. A patch test can be useful to detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema. In Vietnam, patch test has not been used before, so we conduct this study. AIM: To identify causative allergens by using patch test with 28 standard allergens in consecutive patients. METHODS: A group of 300 HE patients from the National Hospital of Dermatology and Venereology (NHDV) in Vietnam were enrolled in this study. They were divided into 4 groups-ACD, ICD, AD and unknown aetiology. The patient was patch tested with 28 standard allergens to identify the causative agents. RESULTS: Among the 300 HE enrolled patients, ACD accounted for 72.7%, AD and ICD had the same rate of 12.7%. 39.3% of the patients had a positive patch test. Reaction to nickel sulfate was the most common (10.3%), followed by potassium dichromate (9.7%), cobalt (4%) and fragrance mix (3.1%). About one-third of the cases had relevant clinical reactions correlated with the contact agents and clinical history. Males reacted to cement, thiuram mix and formaldehyde more than females, while females reacted to a nickel more than males. CONCLUSIONS: Hand eczema has variable clinical features and diverse aetiology. ACD is an important cause of hand eczema that can be managed with a patch test to detect causative allergens. Nearly 40% of HE cases had positive patch test. Relevant patch test reactions were seen in one-third of the patients. We propose using patch test detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema.

scholarly journals Common Contact Sensitizers among Patients with Hand Eczema: A Multicenter-Study in Nepal

2016 ◽  
Vol 14 (1) ◽  
pp. 14-17
Author(s):  
S. Bhattarai ◽  
A. Rijal ◽  
S. Agrawal
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Test ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
College Teaching ◽  
Hand Eczema ◽  
Contact Allergens ◽  
Allergic Contact

Introduction: Allergic contact dermatitis in Nepal is not an uncommon disorder. Patch testing is a well established method of diagnosing allergic contact dermatitis. Patients with contact dermatitis are well known to have impaired quality of life which often leads to frequent dermatological consultations.Objective: Lack of data from Nepal has prompted us to undertake this study with the aims to know the frequency of allergic contact dermatitis and the commonest contact allergens among the patients with Hand eczema attending the out-patient department of dermatology, B.P. Koirala Institute of Health Sciences and Kathmandu Medical College Teaching Hospital.Material and Methods: A total of 256 patients were included in the study. Out of them 195 with hand eczema agreed to participate and undergo patch testing. The antigens used included the Indian standard series of patch test allergens approved by Contact and Occupational Dermatoses Forum of India.Results: Hundred and ten cases (56.4%) were patch test positive (PTP) at 48 as well as 96 hours to at least one allergen. PTP was seen more commonly in females. The most common allergen in females was nickel sulphate followed by cobalt chloride, gentamicin and mercapto mix while males were positive to potassium dichromate, followed by epoxy resin, fragrance mix and nickel sulphate.Conclusion: Patch testing has proved a useful tool for the detection of allergic contact dermatitis and for identification of contact allergens. When positive reactions correlate with environmental exposure the test usually assists the physician in establishing the cause of dermatitis, hence treating the patients and improving their quality of life.Nepal Journal of Dermatology, Venereology & Leprology, Vol.14(1) 2016, pp.14-17

scholarly journals Results of patch tests (using Indian standard battery of allergens) in cement workers with clinically diagnosed allergic contact dermatitis to cement: A cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Thacharamban Mansoorali ◽  
Abdulsalam Sarin
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Test ◽  
Positive Reaction ◽  
Patch Testing ◽  
Tertiary Referral ◽  
Test Reaction ◽  
Tertiary Referral Center ◽  
Positive Patch Test ◽  
Allergic Contact

Objectives: The objective of the study was to identify the allergens showing positive patch test reaction (using Indian standard battery of allergens) in cement workers with clinically diagnosed allergic contact dermatitis (CD) to cement attending a tertiary referral center. Materials and Methods: We included cement workers with clinically diagnosed allergic CD to cement who attended the dermatology outpatient clinic of our tertiary referral center from January 2013 to December 2013. We did patch testing in all the cases ( after subsidence of active dermatitis) with Indian standard battery of patch test allergens and documented the allergens that showed a positive reaction. Results: Forty-seven (94%) of the 50 study participants showed a positive reaction to one or more of the allergens. The most common allergen that showed a positive reaction was potassium dichromate (43/50, 86%). Twenty-five patients (50%) showed positive reactions to more than 1 allergen. Four patients (8%) showed positive reactions only to allergens that were not seen in cement. Limitations: Small sample size and lack of information on clinical response of dermatitis to avoidance of identified allergen were the major limitations. Conclusion: Twenty-five (50%) patients showing positive reactions to more than 1 allergen tested and 4 (8%) showing positive patch test reaction to none of the allergens in cement (but to other allergens) highlight the role of patch testing in identifying the probable allergens in patients with clinically diagnosed allergic CD to cement.

scholarly journals Patch Testing In Nepalese Population: A Single Center Study From Kathmandu, Nepal

2019 ◽  
Vol 17 (1) ◽  
pp. 12-16
Author(s):  
Sushil Paudel ◽  
Guma Pun ◽  
Niraj Parajuli ◽  
Rabindra Sharma
Keyword(s):  
Patch Test ◽  
Patch Testing ◽  
Nickel Sulfate ◽  
Hand Eczema ◽  
Allergic Reactions ◽  
Positive Patch Test ◽  
Facial Eczema ◽  
Allergic Contact ◽  
Sensitization Pattern ◽  
Different Parts

Introduction: Patch testing is a diagnostic tool used in investigation to identify specific allergens in allergic contact dermatitis (ACD). It helps find the prevalence and the trends of contact sensitization in the community. Objective: To report the two year patch test results from a central hospital in Kathmandu. Materials and Methods: Consecutive consenting patients of suspected ACD were patch tested with an Indian standard Series (Systopic) from June 2014 to August 2016. Results: Out of 141 patients tested, 89 were female (63.12%) and 52 were male (36.88%). Hand eczema was the commonest pattern (53 patients) followed by persistent and recurrent eczema (44 patients) and face eczema (25 patients). Fifty- five patients (39%) had at least 1 positive allergic reaction. Among these, 16.31% were male and 22.70% were female. The most common allergen was nickel sulfate (19.9%) followed by fragrance mix (7.8%) and paraphenyldiamine (PPD) (6.4%). Out of total positive cases 27 (21 females and 6 males) had shown strong positive reactions (++). The Nickel Sulfate was responsible in majority of cases (18/27 cases). Farmers had the highest (57.14%) rate of positive allergic reactions followed by housewives (39.62%). According to the regional eczema, patients with persistent and recurrent eczema of different parts of body had the highest rate of positive allergic reactions (47.72%). Almost half of patient with facial eczema (40%) had positive patch test. Conclusion: Larger studies are required in the different parts of the country to find a more accurate data regarding the sensitization pattern in Nepalese population.

scholarly journals Role of footwear allergens in juvenile plantar dermatosis

2017 ◽  
Vol 3 (2) ◽  
pp. 223
Author(s):  
Shyni Perumbil ◽  
Kunnummal Muhammed ◽  
Sarita Sasidharan Pillai
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Potassium Dichromate ◽  
Past History ◽  
Test Reaction ◽  
Positive Patch Test ◽  
International Contact ◽  
History Of ◽  
Age And Sex

<p class="abstract"><strong>Background:</strong> Juvenile plantar dermatosis (JPD) is characterized by shiny dry fissured dermatitis of the plantar surface of the foot, affecting children aged 3-14years. The most accepted theory is that JPD is a frictional contact dermatitis of the forefoot in which atopics are more prone to develop. Allergic contact dermatitis remains a close differential diagnosis; it can aggravate the predisposing JPD. In this background we carried out a study among children aged fourteen years and below with clinically diagnosed JPD to know the age and sex profile, aggravating factors and clinical features in this part of the country<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> All children aged 14 years and below with JPD attending our outpatient department from November 2006 to November 2007 were included in this study. Using a preset proforma, data regarding age and sex, information on any relation to footwear, past history of allergic disorders in person or family members was collected. All the 40 patients were patch tested using the footwear allergen series in petrolatum base. Patch test unit was removed after 48hours and the results were interpreted using criteria laid down by International Contact Dermatitis Group (ICDRG). The data was analyzed and made an attempt to understand the role of footwear allergy in JPD.</p><p class="abstract"><strong>Results:</strong> 22 girls and 18 boys attended our OPD with JPD between the age group of 4-14 years. 52.5% were using footwear made of plastic; 25%used leather; 12.5% rubber footwear. Patients presented with erythema and glazed appearance of foot along with fissuring. The areas of involvement were distal soles and toes in 70%, distal sole alone in 7.5% and distal sole and dorsum of toes in 22.5% of patients. Personal history of atopy was documented in 15% of patients and family history of atopy was present in 20% of cases. 20% of patients complained of exacerbation with footwear. Of the 40 patients who underwent patch testing, 10% only showed <span lang="EN-IN">positive patch test reaction mainly to potassium dichromate (5%). </span></p><p class="abstract"><strong>Conclusions:</strong> JPD is not an uncommon disease and it predominantly affects school going children. Seasonal variation was associated with aggravation of disease. Specific footwear was identified to cause flare ups in a significant percentage of study population (20%) and this was proven by patch test results in half of them. Though nearly one fifth of the affected had an atopic diathesis in person or family, the present data suggests that JPD is not exclusive to atopics. A large sized study is required to <span lang="EN-IN">evaluate the role of footwear in JPD.</span></p>

scholarly journals Association Between IL16 Gene Polymorphism and Allergic Contact Dermatitis Among Construction Workers

2019 ◽  
Vol 11 ◽  
pp. 117863451988055
Author(s):  
Eman Omar Khashaba ◽  
Mohammad A Gaballah ◽  
Ahmed Fathy State ◽  
Mona Elwassefy
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Test ◽  
Potassium Dichromate ◽  
Gene Promoter ◽  
Mercury Chloride ◽  
Gene Distribution ◽  
Positive Patch Test ◽  
Significant Difference ◽  
Allergic Contact

Objectives: First, this research was instituted to identify common allergens, and second, to test the association between IL16 gene promoter polymorphism rs4778889 T/C and allergic contact dermatitis (ACD). Methods: A case control study was conducted in dermatology outpatients’ clinic. Study subjects received interview-based semi-structured questionnaire, complete skin examination, IL16 gene promoter was investigated by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis, and IQ Ultra™ patch test units (Chemotechnique Diagnostics AB, Sweden) with 10 substances were used. Results: Most of the prevalent cases had positive patch test (93.3%). The most common clinical presentation of ACD in our patients was itching (96.7%), followed by dryness (86.75%), erythema (76.7%), and fissuring (76.7%). There was higher CC gene distribution among cases, but there was no statistically significant difference. IL16 gene distribution was nearly similar among different clinical presentations. Formaldehyde showed statistically significant higher frequency for CC. The most common allergen found was mercury chloride (76.6%), followed by potassium dichromate (26.6%) and cobalt chloride (20%). Conclusions: The current study found prominent metal sensitization (mercury chloride) over the previously known potassium dichromate. There was no statistically significant IL16 gene distribution among cases compared with control. However, C allele was more frequently encountered in cases. Further studies are required to test the association with IL16 genotype and ACD and highlight the new trends in metal sensitization among cement-exposed workers.

scholarly journals Clinico-epidemiological study of role of patch test in hand eczema

2019 ◽  
Vol 5 (2) ◽  
pp. 357
Author(s):  
Ashok S. Hogade ◽  
P. Anusha
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Potassium Dichromate ◽  
Hand Eczema ◽  
Gold Standard Method ◽  
Occupational Contact Dermatitis ◽  
International Contact ◽  
Contact Allergen ◽  
Exogenous Factors ◽  
Allergic Contact

<p class="abstract"><strong>Background:</strong> Hand eczema is a common distressing condition in different occupational groups caused by various endogenous and exogenous factors. It appears to be the most common occupational skin disease, comprising 80% or more of all occupational contact dermatitis. Patch test at present is the only scientific method to diagnose the contact allergen and in subsequent management of patient.</p><p class="abstract"><strong>Methods:</strong> An observational study of patch test was conducted on 100 patients of hand eczema in the department of DVL, Basaveshwara Teaching and General Hospital, Kalaburagi. After detailed history and complete examination, patch testing was done using Indian Standard Series and graded by International Contact Dermatitis Research Group criteria at 48 hours and 72 hours.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 100 patients, there were 28 females and 72 males. The commonest age group seen was 20-40 years followed by 40-60 years. Commonest sensitizers were to potassium dichromate (34%) followed by nickel (18.7%), Parthenium (12.5%), PPD (7.8%), other (26%). Out of 64 patients who were positive, 82.8% were positive to single allergen, 10% to two allergens and 6.2% to multiple allergens.</p><p class="abstract"><strong>Conclusions:</strong> Patch test is considered as gold standard method for diagnosis of allergic contact dermatitis and thus preventing the morbidity of repeated episodes of eczema.</p>

scholarly journals EVALUATION OF PATCH TESTING IN CONTACT DERMATITIS PATIENTS ATTENDING TERTIARY CARE CENTRE IN KARAIKAL

2021 ◽  
pp. 20-22
Author(s):  
SivaKumar Sivasubramaniam ◽  
Ambujam Govindasamy ◽  
Kode Leela Sravanthi ◽  
Brindha Pandiyan
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
Tertiary Care ◽  
Nickel Sulfate ◽  
Cobalt Sulfate ◽  
Tertiary Care Centre ◽  
Positive Patch Test ◽  
Contact Eczema

Introduction: Allergic contact dermatitis (ACD) is a growing concern due to increased use of cosmetics and topical medications routinely and exposure to a large number of allergens on day-to-day basis. Patch testing is a reliable method for detecting the causative antigens in suspected cases. Aims And Objectives: To assess the demographic profile, pattern of ACD, and patch test profile of suspected cases of ACD attending contact dermatitis clinic of our department. Materials And Methods: It was a prospective study in which all the patients with suspected ACD attending OPD of department of dermatology over a 3 month period were analysed. Patch testing was done using the most common antigens primarily, and other batteries were used depending on patient requirement and availability. Results: A total of 50 patients were enrolled in the contact dermatitis clinic over a period of 3 months. Hand eczema was the most common pattern seen in 23 cases followed by feet eczema, hand and foot eczema, facial eczema, forearm and leg eczema and photoallergic contact eczema. A total of 32 (64%) gave positive patch test results, with nickel sulfate being the most common allergen identified followed by cobalt sulfate & potassium dichromate. Conclusion: Common allergens identified in our study were more or less similar to studies from other parts of India

scholarly journals Patch test standard series recommended by the Brazilian Contact Dermatitis Study Group during the 2006-2011 period

2013 ◽  
Vol 88 (6) ◽  
pp. 1015-1018 ◽  
Author(s):  
Ida Alzira Gomes Duarte ◽  
Greta Merie Tanaka ◽  
Nathalie Mie Suzuki ◽  
Rosana Lazzarini ◽  
Andressa Sato de Aquino Lopes ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Nickel Sulfate ◽  
Study Group ◽  
Test Results ◽  
Standard Series ◽  
Positive Patch Test ◽  
Follow Up Study ◽  
Allergic Contact

A retrospective study was carried out between 2006-2011. Six hundred and eighteen patients with suspected allergic contact dermatitis underwent the standard patch test series recommended by the Brazilian Contact Dermatitis Research Group. The aim of our study was to evaluate the variation of positive patch-test results from standard series year by year. The most frequently positive allergens were: nickel sulfate, thimerosal and potassium bichromate. Decrease of positive patch-test results over the years was statistically significant for: lanolin (p=0.01), neomycin (p=0.01) and anthraquinone (p=0.04). A follow-up study should be useful in determining which allergens could be excluded from standard series, as they may represent low sensitization risk.

scholarly journals Study of Common Allergens in Patients with Allergic Contact Dermatitis: A Hospital Based Study

2021 ◽  
Vol 23 (1) ◽  
pp. 16-22
Author(s):  
Arnija Rana ◽  
S Shrestha ◽  
AK Jha ◽  
DP Thapa ◽  
S Joshi ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Test ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
Nickel Sulphate ◽  
Dermatology Department ◽  
Positive Patch Test ◽  
Number Of Patients ◽  
Allergic Contact

Allergic contact dermatitis (ACD) is one of the most common diseases presenting to the Dermatology department. The one and only method of preventing as well as treating this disease is avoidance of the allergen causing it. The identification of the allergen causing the ACD is possible by performing patch testing. The purpose of this study was to identify common allergens among patients with ACD using Indian standard series (ISS) of patch test. Clinically suspected cases of ACD were included in the hospital based cross-sectional study from January to December 2017. These cases underwent patch testing with the ISS. The study assessed the following variables: sex, age, occupation, site and positive patch test results. There were a total of 58 patients among which, 36.2% were males and 63.8% were females with a mean age of 32.36±12.51 years. Positive patch test reactions were seen in 63.0% of patients. The most common allergens were nickel sulphate (51.4%), fragrance mix (37.8%), potassium dichromate (8.1%), colophony (8.1%) and black rubber mix (8.1%). Among male, most common allergens were fragrance mix (57.1%), nickel sulphate (28.6%) and potassium dichromate (21.4%) while in female, most common allergens were nickel sulphate (65.2%) and fragrance mix (26.1%). In our study, majority of the allergens were positive. Hence, the ISS used in the study might be suitable in the context of Nepalese population. However, further similar studies on large number of patients with multiple allergens are required to determine the exact number of contact allergens prevalent in our population.

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