Total Penectomy and Perineal Urethrostomy Management of Penile Squamous Cell Carcinoma with Paraffinoma in Single Center Hospital: A Rare Case Report

BACKGROUND: Penile cancer is a rare condition, affecting less than 1% of the adult male population [1]. The risk of penile cancer increases significantly with age, poor hygiene, and the presence of the prepuce. The most common type encountered is squamous cell carcinoma (SCC). Clinically penile cancer appears as small lesions with induration and erythema or as large infiltrative ulcerative lesions. As the disease progresses, complaints such as itching, bleeding, discharge, foul odor, and pain occurred. CASE REPORT: A 63-year-old man with poor hygiene and has a history of diabetes mellitus had penis ulcers since 5 years ago. On physical examination, an ulcer with the size of 12 × 12 × 10 cm was found growing pus (-). Biopsy had done and confirmed SCC as a result. Pelvic multiple slice CT shows growth covering the entire shaft of the penis down to the base. The patient had a previous history of using silicone injection 35 years ago and causing Sclerofibromatosis. The patient was planned to undergo surgery with clinical diagnosis T4N0M0. Total penectomy was performed with an elliptical incision around the base with a margin of 2 cm. Sclerofibromatosis and the surrounding tissue were excised to the base of the penis followed by perineal urethrostomy. There was no problem postoperatively. The patient went home after staying in the hospital for 96 h. The surgical specimen revealed SCC with free of tumor excision margin. CONCLUSIONS: Injections with silicone to enlarge the penis cannot be justified. The process can trigger a chronic inflammatory reaction associated with penile malignancy. Total penectomy and wide excision with urethral perineostomy could be optimal initial treatment.

Download Full-text

Epidemiology of Squamous Cell Carcinoma in Response to Different Hazardous Chewing Causes in Lahore, Pakistan-a Unicenter study

Pakistan BioMedical Journal ◽

10.52229/pbmj.v2i2.20 ◽

2020 ◽

Vol 2 (2) ◽

Author(s):

Maria Fareed Siddiqui ◽

Umair Yaqoob ◽

Morad Yaser Al Mostafa

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oral Surgery ◽

Tertiary Care ◽

Disease Onset ◽

Previous History ◽

Care Hospital ◽

History Of ◽

Surgery Department

Oral squamous cell carcinoma (OSCC) being the world’s most prevailing and frightening cancerousdisorder lacks the sufficient data in Pakistan despite of its higher magnitude and prevalence. Objective:This study was specifically designed and conducted with the aim to identify the frequency of this disorderalong with causative factors in past three years in a tertiary care hospital of Lahore, Pakistan. Methods:Epidemiological study was conducted using retrospective randomized method and all pre-requisites werefilled. The clinical profiles of patients were collected from Maxillofacial and Oral Surgery Department ofPathology, Mayo Hospital Lahore. Patients who had undergone treatment for OSCC were contacted andinterviewed for information about demographic regions, previous history of malignancy, disease onset,chewing habits, exposure to pesticides, industrial exposure to metals etc. and all particulars were not andcompiled on questionnaire. Results: A total of 54 patients from different districts of Punjab participatedin the study. Percentages for each possible causative chewing habit were calculated and 87.50 % ofpopulation was found addicted to different habits. Genetic factor might have contributed in remaining fordevelopment of OSCC. Conclusions: Informative data provided in this study will be helpful to be used bythe government and private health agencies while designing and planning management of oral healthproblems and allocating health budgets in focusing this issue.

Download Full-text

A Case of Urinary Bladder Squamous Cell Carcinoma Post Renal Transplant with a Previous History of Bilharziasis.

Transplantation Journal ◽

10.1097/01.tp.0000543568.85120.17 ◽

2018 ◽

Vol 102 ◽

pp. S646-S647

Author(s):

Ashraf Attia ◽

Mohamed Saied ◽

Salem Alqurashi ◽

Ahmad Chabalout ◽

Ihab Mahmoud ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Renal Transplant ◽

Urinary Bladder ◽

Cell Carcinoma ◽

Squamous Cell ◽

Previous History ◽

History Of

Download Full-text

Surgery for pulmonary malignancies in patients with a previous history of head and neck squamous cell carcinoma

Surgery Today ◽

10.1007/s00595-013-0593-6 ◽

2013 ◽

Vol 44 (4) ◽

pp. 646-652 ◽

Cited By ~ 3

Author(s):

Ryu Kanzaki ◽

Masayoshi Inoue ◽

Masato Minami ◽

Yasushi Shintani ◽

Tomoyuki Nakagiri ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Previous History ◽

Neck Squamous Cell Carcinoma ◽

History Of

Download Full-text

Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma

Case Reports in Oncological Medicine ◽

10.1155/2012/912178 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Andrew Austin Gassman ◽

Emil Fernando ◽

Casey Jacob Holmes ◽

Umesh Kapur ◽

Joshua M. Eberhardt

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Previous History ◽

Cerebral Metastasis ◽

Anal Squamous Cell Carcinoma ◽

Dismal Prognosis ◽

The Face ◽

History Of ◽

Poorly Differentiated

Squamous cell carcinoma of the anus is a relatively uncommon GI malignancy. When it does occur, it metastasizes in only a small minority of patients. Spread of anal squamous cell carcinoma to the brain is exceedingly rare, and has been previously reported only three times in the medical literature. We report the case of a 67 year old male who was diagnosed on presentation with a poorly differentiated anal squamous cell carcinoma that already had a solitary metastasis to the liver. While the tumors were initially responsive to chemoradiotherapy, the patient’s primary and liver lesions recurred. The patient then underwent synchronous abdominoperineal resection for the primary lesion and a liver lobectomy for the metastasis. Soon thereafter, the patient developed focal neurologic symptoms and was found to have an intracranial lesion that on biopsy demonstrated metastatic squamous cell carcinoma. This case highlights the fact that patients with a previous history of anal squamous cell carcinoma can occasionally develop cerebral metastasis. Furthermore, cerebral metastases from anal squamous cell carcinoma portend a dismal prognosis even in the face of aggressive medical and surgical therapy.

Download Full-text

Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

Case Reports in Oncological Medicine ◽

10.1155/2020/6192754 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Michelle Bernshteyn ◽

Alexandria Smith-Hannah ◽

Amit S. Dhamoon

Keyword(s):

Myocardial Infarction ◽

Squamous Cell Carcinoma ◽

Case Report ◽

Chronic Lymphocytic Leukemia ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymphocytic Leukemia ◽

Small Lymphocytic Lymphoma ◽

Metastatic Squamous Cell Carcinoma ◽

History Of

A 66-year-old woman presented to the hospital with a one-month history of shortness of breath, fatigue, and postmenopausal vaginal bleeding and a one-week history of chest pain. This case report discusses the rare synchronous occurrence of two different malignancies in the setting of non-ST segment elevation myocardial infarction and the relation between these unfortunate events. Besides the case presented in this report, there have been only 13 reported cases of synchronous chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with metastatic squamous cell carcinoma. While it is well known that malignancy causes a hypercoagulable state, there are other mechanisms which may have contributed to the patient’s myocardial ischemia including external vascular compression, tumor lysis syndrome, and anemia. This case report discusses the rarity of synchronous malignancies but the importance of understanding and consideration of cardiac events in this population.

Download Full-text

Hidden penile squamous cell carcinoma: A case report

Canadian Urological Association Journal ◽

10.5489/cuaj.1883 ◽

2014 ◽

Vol 8 (5-6) ◽

pp. 433

Author(s):

Sam Neufeld ◽

Tadeusz Kroczak ◽

Darrel Drachenberg

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Penile Cancer ◽

Interesting Case ◽

Rare Malignancy ◽

Penile Squamous Cell Carcinoma

Penile cancer is a rare malignancy that typically presents as a superficial lesion. We present an interesting case of subepithelial penile cancer presenting without superficial manifestation.

Download Full-text

Conformal Radiotherapy for Squamous Cell Carcinoma of Gallbladder: A Case Report

Case Reports in Medicine ◽

10.1155/2010/645172 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Jia-zhou Hou ◽

Zhao-chong Zeng ◽

Jing Sun ◽

Yuan Ji

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Conformal Radiotherapy ◽

Conformal Radiation Therapy ◽

3 Dimensional ◽

Carcinoma Of The Gallbladder ◽

History Of ◽

Multiple Liver Metastases

Background. Squamous cell carcinoma of the gallbladder is a rare disease with symptoms developing late in its course, so that it often presents as an aggressive tumor with a poor prognosis.Case report. We describe a 58-year-old male with a 5-week history of hypodynamia. He was found to have squamous cell carcinoma of the gallbladder with liver invasion and lymph node metastases. He underwent treatment with 3-dimensional conformal radiation therapy (CRT). A follow-up computer tomography (CT) scan showed complete tumor remission 2 months after the completion of CRT. The patient survived for 14 months after the end of treatment and died of multiple liver metastases.Conclusion. The efficacy of radiotherapy in this case is encouraging and suggests a potential role for such therapy in similar cases. The benefit in terms of survival warrants further study.

Download Full-text