Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis

BackgroundSensitisation to moulds and Staphylococcus aureus enterotoxins (SEs) is associated with the pathophysiology of both asthma and chronic rhinosinusitis (CRS). The purpose of this study was to clarify the contribution of sensitisation to these allergens to Type 2 inflammation in the blood, nose and the lower airways, and clinical outcomes in CRS patients.MethodsWe prospectively enrolled 56 CRS patients who underwent endoscopic sinus surgery (ESS) (20 with comorbid asthma) and 28 healthy controls between October 2015 and December 2017. CRS patients were followed up for 12 months after surgery. Type 2 inflammation-related biomarkers were analysed using blood, resected tissue samples and sputum. 10 allergens including Alternaria, Aspergillus and SEs were measured. Type 2 inflammation-related biomarkers and clinical outcomes were compared in the stratification with the presence or absence of allergen sensitisation.ResultsSensitisation rate to moulds and SEs in asthmatic patients was increased when changing the cut-off value of specific IgE titre from 0.35 UA·mL−1 to 0.10 UA·mL−1 (1.7- and 4.5-fold, respectively). Moulds and SEs affected the prevalence of asthma and eosinophilic CRS by interacting with each other. All Type 2 inflammation-related biomarkers except for eosinophils in sinus tissue were significantly higher in patients with mould or SE (mould/SE) sensitisation (≥0.10 UA·mL−1) (n=19) than in those without (n=37) and healthy subjects (all p<0.05). Meanwhile, mould/SE sensitisation did not affect longitudinal changes in clinical outcomes after ESS. Changes in serum mould/SE-IgE levels after ESS remained unclear.ConclusionMould/SE sensitisation (≥0.10 UA·mL−1) may affect the development of Type 2 inflammation and clinical outcomes in CRS patients.

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Association between specific IgE to Staphylococcus aureus enterotoxins A and B and asthma control

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2015.06.017 ◽

2015 ◽

Vol 115 (3) ◽

pp. 191-197.e2 ◽

Cited By ~ 19

Author(s):

Akihiko Tanaka ◽

Shintaro Suzuki ◽

Shin Ohta ◽

Ryo Manabe ◽

Hitomi Furukawa ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Asthma Control ◽

Specific Ige ◽

Staphylococcus Aureus Enterotoxins

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Staphylococcus aureus Enterotoxins as Immune Stimulants in Chronic Rhinosinusitis

Chronic Rhinosinusitis ◽

10.3109/9781420014020-14 ◽

2007 ◽

pp. 179-200

Keyword(s):

Staphylococcus Aureus ◽

Chronic Rhinosinusitis ◽

Immune Stimulants ◽

Staphylococcus Aureus Enterotoxins

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Staphylococcus Aureus Enterotoxins in Chronic Rhinosinusitis

Otolaryngology ◽

10.1177/0194599811415823a429 ◽

2011 ◽

Vol 145 (2_suppl) ◽

pp. P265-P265

Author(s):

Lei Cheng ◽

Luping Zhu

Keyword(s):

Staphylococcus Aureus ◽

Chronic Rhinosinusitis ◽

Staphylococcus Aureus Enterotoxins

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Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2012.05.012 ◽

2012 ◽

Vol 130 (2) ◽

pp. 376-381.e8 ◽

Cited By ~ 111

Author(s):

Claus Bachert ◽

Kristel van Steen ◽

Nan Zhang ◽

Gabriele Holtappels ◽

Tom Cattaert ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Risk Factor ◽

Independent Risk Factor ◽

Specific Ige ◽

Staphylococcus Aureus Enterotoxins

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Sensibilization Spectrum in Preschool Children with Atopic Dermatitis

Педиатрическая фармакология ◽

10.15690/pf.v18i4.2292 ◽

2021 ◽

Vol 18 (4) ◽

pp. 286-291

Author(s):

Tat'yana S. Kashinskaya ◽

Natal'ya V. Shahova ◽

Yurij F. Lobanov ◽

Natal'ya K. Bishevskaya

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Milk Proteins ◽

Specific Ige ◽

Cow’S Milk ◽

Food Allergens ◽

Positive Correlation ◽

Weak Positive Correlation ◽

Staphylococcus Aureus Enterotoxins ◽

Airborne Allergens

Background. Atopic dermatitis (AD) is an allergodermathosis that is widespread in children and adult populations. Sensibilization to food allergens prevails in children of early age, and to airborne allergens in older age. Impairments of skin barrier lead to increase in Staphylococcus aureus colonization and finally aggravate the course of AD and the sensibilization level.Objective. The aim of the study is to estimate the sensibilization spectrum in 3-6 years old children with AD and its correlation with severity.Methods. It was cross sectional study with two independent cohorts of 3-6 years old children with and without (healthy) AD. Estimation of sensibilization spectrum and revealing of correlation with disease severity were performed.Results. The study includes 106 children aged 4.4 ± 1.2 year (58.5% boys and 41.5% girls). Polysensibilization was revealed in 28.3% of children. According to our data: 3-6 years old children with AD most often had sensibilization to the cat epithelium (34.9%), cow's milk proteins (22.6%), Dermatophagoides pteronyssinus mite (16.0%). Sensibilization to enterotoxins of Staphylococcus aureus was revealed in 7.5% children. We have recorded weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens. There was no statistically significant correlation between the AD severity and the level of specific IgE to Staphylococcus aureus enterotoxins A and B. Conclusion. The most common sensibilization type among 3-6 years old children with AD was one to airborne allergens. Sensibilization to the cat epithelium prevails among airborne allergens, to the cow's milk proteins — among food allergens. The weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens was revealed. The weak negative correlation with the level of specific IgE to Staphylococcus aureus enterotoxins A and B was revealed, thus the data was statistically insignificant.

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Faculty Opinions recommendation of The effects of nitric oxide on Staphylococcus aureus biofilm growth and its implications in chronic rhinosinusitis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13988976.15445088 ◽

2012 ◽

Author(s):

Kristin Seiberling

Keyword(s):

Nitric Oxide ◽

Staphylococcus Aureus ◽

Chronic Rhinosinusitis ◽

Biofilm Growth

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Rectal Staphylococcus aureus Carriage and Recurrence After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps: A Prospective Cohort Study

Ear Nose & Throat Journal ◽

10.1177/01455613211019716 ◽

2021 ◽

pp. 014556132110197

Author(s):

Yue Peng ◽

Zhao Liu ◽

Zhijian Yu ◽

Aiwu Lu ◽

Tao Zhang

Keyword(s):

Staphylococcus Aureus ◽

Cohort Study ◽

Regression Model ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Prospective Cohort ◽

Multivariate Regression ◽

Nasal Polyps ◽

Sinus Surgery ◽

Multivariate Regression Model

Objective: Chronic rhinosinusitis with nasal polyps (CRSwNPs) remains a major challenge due to its high recurrence rate after endoscopic sinus surgery (ESS). We aimed to investigate the risk factors of recurrence among patients who underwent ESS for Chronic rhinosinusitis (CRS). Methods: Prospective cohort study including 391 cases in a single institution receiving ESS were included for analysis from 2014 and 2017. Baseline characteristics including rectal Staphylococcus aureus ( S aureus) carriage in patients receiving ESS for CRSwNPs. The primary outcome was the recurrence of CRSwNPs. Multivariate regression model was established to identify independently predictive factors for recurrence. Results: Overall, 142 (36.3%) cases with recurrence within 2 years after ESS were observed in this study. After variable selection, multivariate regression model consisted of 4 variables including asthma (odds ratio [OR] = 3.41; P < .001), nonsteroidal anti-inflammatory drug allergy (OR = 2.27; P = .005), previous ESS (OR = 3.64; P < .001), and preoperative carriage of S aureus in rectum (OR = 2.34; P = .001). Conclusions: Based on our results, surgeons could predict certain groups of patients who are at high risk for recurrence after ESS. Rectal carriage of S aureus is more statistically related to the recurrence of CRSwNP after ESS compared with skin and nasal carriage.

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