Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis

Thrombocytopenia is a relatively uncommon extra-hepatic manifestation of uncomplicated chronic hepatitis B virus (HBV) infection. This study has two aims: to assess the prevalence of thrombocytopenia in non-cirrhotic patients with chronic hepatitis B (CHB); and to determine the association of certain variables with thrombocytopenia in Duhok province. It is a case control study conducted in Azadi Teaching Hospital during June 2016 - May 2019. Chronic active hepatitis B was defined according to the following parameters: the presence of detectable hepatitis B surface antigen (HBsAg) in the blood longer than six months, positive or negative HBeAg, HBV-DNA level >2000 IU/ml, elevated ALT, and/or at least moderate histopathological fibrosis. Thrombocytopenia was defined as platelet counts below 150,000/μl. The obtained results were analyzed by entering data into Microsoft Excel 2010. A total of 379 CHB patients and 200 cases as control were enrolled in this study. Their mean ages were 33.62 ± 14.48 and 40.72 ± 18.56 for HBV and control cases, respectively. There were 236 (62.27%) males in the HBV patients and 109 (54.50%) males in the control group. Comparing both groups, significant association was found between HBV and younger age, cigarette smoking, and alcohol consumption. Chronic active hepatitis B without liver cirrhosis was strongly associated with an increased rate of thrombocytopenia. This finding is paramount as it is statistically significant (P = 0.042). Significant association with younger age and Syrian nationality was found more in CHB patients with thrombocytopenia compared to non-thrombocytopenic. In conclusion, chronic active hepatitis B is strongly associated with thrombocytopenia. As hypersplenism resulting from liver cirrhosis was excluded in our patients, the cause of thrombocytopenia is due to other mechanisms. Therefore, it is important to consider CHB in the differential diagnosis of patients presenting with isolated thrombocytopenia. Older age and Syrian nationality were predictors for developing thrombocytopenia in chronic active HBV infection. Asian J. Med. Biol. Res. June 2019, 5(3): 207-211

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Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: A longitudinal study

Journal of Clinical Ultrasound ◽

10.1002/jcu.1870210502 ◽

1993 ◽

Vol 21 (5) ◽

pp. 303-308 ◽

Cited By ~ 127

Author(s):

Deng-Yn Lin ◽

I-Shyan Sheen ◽

Cheng-Tang Chiu ◽

Shi-Ming Lin ◽

Yow-Chii Kuo ◽

...

Keyword(s):

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Longitudinal Study ◽

Hepatitis B ◽

Chronic Hepatitis B

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Seropositivity for delta hepatitis in patients with chronic hepatitis B and liver cirrhosis in Turkey: a meta-analysis

Liver International ◽

10.1111/j.1478-3231.2008.01673.x ◽

2008 ◽

Vol 28 (4) ◽

pp. 494-498 ◽

Cited By ~ 50

Author(s):

Halil Değertekin ◽

Kendal Yalçιn ◽

Mustafa Yakut ◽

Cihan Yurdaydin

Keyword(s):

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Meta Analysis

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Clinical effects of entecavir combined with Qianggan pills in chronic hepatitis B patients with compensated liver cirrhosis

World Chinese Journal of Digestology ◽

10.11569/wcjd.v24.i4.583 ◽

2016 ◽

Vol 24 (4) ◽

pp. 583

Author(s):

Wen-Jia Gui

Keyword(s):

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Clinical Effects

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Long-Term Traditional Chinese Medicine Combined with NA Antiviral Therapy on Cirrhosis Incidence in Chronic Hepatitis B Patients in the Real-World Setting: A Retrospective Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/3826857 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Zhi-Jun Hou ◽

Jing-Hao Zhang ◽

Xin Zhang ◽

Qi-Hua Ling ◽

Chao Zheng ◽

...

Keyword(s):

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Hepatitis B ◽

Antiviral Therapy ◽

Chronic Hepatitis B ◽

Cumulative Incidence ◽

Histological Evaluation

Objective. To evaluate the impact of long-term Traditional Chinese Medicine (TCM) syndrome differentiation combined with antiviral therapy with Nucleos (t) ide analogues (NAs) on the incidence of cirrhosis in patients with chronic hepatitis B. Methods. This retrospective cohort study included 521 patients with chronic hepatitis B who underwent a treatment course of ≥3 years from 1998–2019. Of the 521 patients, 261 were defined as TCM users while 260 were TCM nonusers (control group). All the enrolled subjects were followed up until February 2019 to measure the incidence and hazard ratio (HR) of cirrhosis, and the Cox proportional hazards regression model was used to analyze the independent factors affecting the occurrence of cirrhosis. Results. The cumulative incidence of TCM users and nonusers was 6.9% and 13.5%, respectively (P=0.013). Results of the Kaplan–Meier analysis demonstrated that TCM users had a significantly lower cumulative incidence of cirrhosis than TCM nonusers (P=0.011), and TCM users had a significantly lower liver cirrhosis risk than TCM nonusers (adjusted HR = 0.416, 95% CI, 0.231–0.749). The histological evaluation revealed improved fibrosis in 45.0% of TCM users and 11.1% of TCM nonusers (P=0.033). The analysation of the prescriptions including total 119 single Chinese herbs medicinal demonstrated that “replenish qi and fortify the spleen,” “clear heat and dispel dampness,” and “soothe the liver and regulate qi” are the main treatment methods of TCM for CHB. Conclusions. Our study demonstrated that long-term TCM use may attenuate liver cirrhosis risk in patients with chronic hepatitis B (CHB).

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