High frequency of tetraploidy detected in malignant melanoma of Japanese patients by fluorescence in situ hybridization.

2000 ◽  
Author(s):  
S Satoh ◽  
T Hashimoto-Tamaoki ◽  
J Furuyama ◽  
K Mihara ◽  
M Namba ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Malignant Melanoma ◽  
Fluorescence In Situ Hybridization ◽  
High Frequency ◽  
Japanese Patients

scholarly journals Presence of 15p Marker D15Z1 on the Short Arm of Acrocentric Chromosomes is Associated with Aneuploid Offspring in Mexican Couples

2019 ◽  
Vol 20 (21) ◽  
pp. 5251 ◽  
Author(s):  
Sandra Ramos ◽  
Rebeca Rodríguez ◽  
Oscar Castro ◽  
Patricia Grether ◽  
Bertha Molina ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
High Frequency ◽  
Trisomy 21 ◽  
Mexican Population ◽  
The Other ◽  
Human Populations ◽  
Nucleolar Organization ◽  
Acrocentric Chromosomes

Variation in the location of the 15p region D15Z1 is recognized as a polymorphism in several human populations. We used high-stringency Fluorescence In Situ Hybridization (FISH) to detect D15Z1 in a Mexican cohort. Here, we report the presence of extra D15Z1 sequences on the p-arm of acrocentric chromosomes other than 15 in two groups of Mexican couples, one with healthy offspring (n = 75) and the other with aneuploid offspring (n = 87), mainly trisomy 21. The additional D15Z1 polymorphism was significantly increased in individuals with aneuploid offspring (26.4%), in comparison to individuals with healthy offspring (14%). The most frequent acceptor chromosome of D15Z1 was chromosome 13p, followed by 14p, and finally, 21p. Our results show an overall frequency of 21.6% of this polymorphism in the Mexican population and suggest that its presence might be associated with the mis-segregation of other acrocentric chromosomes and aneuploid offspring. The high frequency of the polymorphism of the D15Z1 sequence on acrocentric chromosomes other than 15 suggests a sequence homogenization of the acrocentric p arms, related to the important function of the centromere and the nucleolar organization region, which flank satellite III DNA.

High frequency of trisomy 8 in acute promyelocytic leukemia: A fluorescence in situ hybridization study

1997 ◽  
Vol 97 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Mario Sessarego ◽  
Giuseppina Fugazza ◽  
Enrico Balleari ◽  
Roberto Bruzzone ◽  
Alberto Ballestrero ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Acute Promyelocytic Leukemia ◽  
High Frequency ◽  
Promyelocytic Leukemia ◽  
Hybridization Study ◽  
Trisomy 8

Increased chromosome 20 copy number detected by fluorescence in situ hybridization (FISH) in malignant melanoma

1997 ◽  
Vol 19 (4) ◽  
pp. 278-285 ◽  
Author(s):  
James H. Barks ◽  
Floyd H. Thompson ◽  
Raymond Taetle ◽  
Jin-Ming Yang ◽  
John F. Stone ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Malignant Melanoma ◽  
Fluorescence In Situ Hybridization ◽  
Copy Number ◽  
Chromosome 20

scholarly journals Fluorescence in situ hybridization as a tool for microstaging in malignant melanoma

2009 ◽  
Vol 22 (8) ◽  
pp. 989-995 ◽  
Author(s):  
Marissa D Newman ◽  
Terakeith Lertsburapa ◽  
Marjan Mirzabeigi ◽  
Mariam Mafee ◽  
Joan Guitart ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Malignant Melanoma ◽  
Fluorescence In Situ Hybridization
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