scholarly journals Weekly administration of paclitaxel and carboplatin with concurrent thoracic radiation in previously untreated elderly patients with locally advanced non-small-cell lung cancer: A case series of 20 patients

2014 ◽  
Vol 2 (3) ◽  
pp. 454-460 ◽  
Author(s):  
JUMPEI TAKESHITA ◽  
KATSUHIRO MASAGO ◽  
SHIRO FUJITA ◽  
AKITO HATA ◽  
REIKO KAJI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Locally Advanced ◽  
Case Series ◽  
Small Cell ◽  
Small Cell Lung ◽  
Weekly Administration ◽  
Thoracic Radiation

scholarly journals Small Cell Lung Cancer in Elderly Patients: A Review

2008 ◽  
Vol 6 (3) ◽  
pp. 333-344 ◽  
Author(s):  
Taofeek K. Owonikoko ◽  
Suresh Ramalingam
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Therapeutic Interventions ◽  
Small Cell Lung ◽  
Platinum Based Chemotherapy ◽  
Thoracic Radiation ◽  
Modality Approach

Small cell lung cancer (SCLC) accounts for approximately 13% of all lung cancer cases. Approximately 40% of those cases are diagnosed in patients older than 70 years, and this proportion continues to rise in contrast to the continued decline in incidence of SCLC among the general population. The optimal strategy to manage limited-stage SCLC involves a combined modality approach with platinum-based chemotherapy and external-beam thoracic radiation therapy. For extensive-stage disease, platinum-based combination chemotherapy is a mainstay of therapy. Elderly patients present unique challenges in terms of drug metabolism and organ reserve, which impact the outcome of therapeutic interventions. However, limited data are available to guide management decisions for SCLC in elderly patients, and therefore this article discusses recommendations for treatment.

Multimodality therapy improves survival in elderly patients with locally advanced non-small cell lung cancer—A retrospective analysis

2012 ◽  
Vol 3 (2) ◽  
pp. 104-110 ◽  
Author(s):  
Harshita R. Paripati ◽  
Nina J. Karlin ◽  
Steven E. Schild ◽  
Sujay A. Vora ◽  
Amylou C. Dueck ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Retrospective Analysis ◽  
Cell Lung Cancer ◽  
Locally Advanced ◽  
Small Cell ◽  
Multimodality Therapy ◽  
Small Cell Lung

Concurrent Chemoradiation in Inoperable, Locally Advanced Non-small Cell Lung Cancer — Comparison of Efficacy and Toxicity in the Elderly

2012 ◽  
Vol 08 (01) ◽  
pp. 24 ◽  
Author(s):  
Christine Collen ◽  
Denis Schallier ◽  
Mark De Ridder ◽  
◽  
◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Locally Advanced ◽  
The Elderly ◽  
Small Cell ◽  
Concurrent Chemoradiation ◽  
Small Cell Lung ◽  
Sequential Administration

Clinicians are faced with the challenge of treating increasing numbers of elderly patients with locally advanced non-small cell lung cancer (LA-NSCLC) and co-morbid conditions. The benefit of combined chemoradiation in the younger patient using the concurrent modality compared with the sequential administration of both modalities has been established in several randomised trials and recent meta-analyses. Because of the underrepresentation of elderly patients in clinical trials on concurrent chemoradiation (CCRT) in LA-NSCLC, treatment guidelines for this age group are not well established. The objective of this report is to summarise the data on efficacy and toxicity of CCRT in the elderly.

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