scholarly journals Isoferulic acid inhibits human leukemia cell growth through induction of G2/M‑phase arrest and inhibition of Akt/mTOR signaling

2020 ◽  
Author(s):  
Zhiguo Long ◽  
Guangjia Feng ◽  
Na Zhao ◽  
Lei Wu ◽  
Hongbo Zhu
Keyword(s):  
Cell Growth ◽  
Leukemia Cell ◽  
Mtor Signaling ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Phase Arrest ◽  
M Phase ◽  
Isoferulic Acid

Diterpenes from Xylopia langsdorffiana Inhibit Cell Growth and Induce Differentiation in Human Leukemia Cells

2009 ◽  
Vol 64 (9-10) ◽  
pp. 650-656 ◽  
Author(s):  
Marianna V. S. Castello Branco ◽  
Maristella C. Anazetti ◽  
Marcelo S. Silva ◽  
Josean F. Tavares ◽  
Margareth F. F. Melo Diniz ◽  
...  
Keyword(s):  
Cell Growth ◽  
Leukemia Cell ◽  
K562 Cells ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Leukemia Cell Lines ◽  
Inhibit Cell Growth ◽  
Nbt Reduction ◽  
Antitumour Effects

Two new diterpenes were isolated from stems and leaves of Xylopia langsdorffi ana, entatisane- 7α,16α-diol (xylodiol) and ent-7α-acetoxytrachyloban-18-oic acid (trachylobane), along with the known 8(17),12E,14-labdatrien-18-oic acid (labdane). We investigated their antitumour effects on HL60, U937 and K562 human leukemia cell lines. We found that xylodiol was the most potent diterpene in inhibiting cell proliferation of HL60, U937 and K562 cells, with mean IC50 values of 90, 80 and 50 μM, respectively. Based on the nitroblue tetrazolium (NBT) reduction assay, all the diterpenes were found to induce terminal differentiation in HL60 and K562 cells, with xylodiol being the most effective. NBT reduction was increased by almost 120% after 12 h exposure of HL60 cells to xylodiol at a concentration lower than the IC50 (50 μM). Thus, xylodiol inhibited human leukemia cell growth in vitro partly by inducing cell differentiation, and merits further studies to examine its mechanism of action as a potential antitumoural agent

A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene

2011 ◽  
Vol 53 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Chao Yuan ◽  
Yu-Sheng Zhang ◽  
Yan-Na Cheng ◽  
Xia Xue ◽  
Wen-Fang Xu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Human Leukemia Cell

Abstract 4788: MiR-509 inhibits human leukemia cell growth

2014 ◽  
Author(s):  
Yee Sun Tan ◽  
Wen-Chih Cheng ◽  
Curt I. Civin
Keyword(s):  
Cell Growth ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Human Leukemia Cell

Synergistic inhibition of human leukemia cell growth by deoxyguanosine and 1-β-d-arabinofuranosylcytosine

1984 ◽  
Vol 33 (7) ◽  
pp. 1059-1063 ◽  
Author(s):  
Steven A. Akman ◽  
Douglas D. Ross ◽  
Christopher C. Joneckis ◽  
Bonnie M. Fox ◽  
Nicholas R. Bachur
Keyword(s):  
Cell Growth ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Synergistic Inhibition ◽  
Human Leukemia Cell
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