scholarly journals LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2

2018 ◽  
Author(s):  
Jian Lu ◽  
Min Chen ◽  
Sumeng Gao ◽  
Jigang Yuan ◽  
Zhu Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Warburg Effect ◽  
Gastric Cancer Cells ◽  
Pyruvate Kinase M2 ◽  
The Warburg Effect

scholarly journals Pyruvate Kinase M2 Plays a Dual Role on Regulation of the EGF/EGFR Signaling via E-Cadherin-Dependent Manner in Gastric Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e67542 ◽  
Author(s):  
Le-Yi Wang ◽  
Yun-Peng Liu ◽  
Li-Gang Chen ◽  
Yan-Ling Chen ◽  
Li Tan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Dual Role ◽  
Dependent Manner ◽  
Egfr Signaling ◽  
Gastric Cancer Cells ◽  
Pyruvate Kinase M2 ◽  
E Cadherin

scholarly journals Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect

2021 ◽  
Vol 30 ◽  
pp. 096368972110275
Author(s):  
Zhen Li ◽  
Lina Yang ◽  
Shuai Zhang ◽  
Jiaqi Song ◽  
Huanran Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Valproic Acid ◽  
Cancer Therapy ◽  
Pyruvate Kinase ◽  
Histone Deacetylases ◽  
Warburg Effect ◽  
Broad Class ◽  
Pyruvate Kinase M2 ◽  
Breast Cancer Cell Growth ◽  
The Warburg Effect

Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer. However, the detail mechanism about the potential role of VPA on the Warburg effect in breast cancer remains unclear. In this study, we highlight that VPA significantly attenuates the Warburg effect by decreasing the expression of pyruvate kinase M2 isoform (PKM2), leading to inhibited cell proliferation and reduced colony formation in breast cancer MCF-7 and MDA-MB-231 cells. Mechanistically, Warburg effect suppression triggered by VPA was mediated by inactivation of ERK1/2 phosphorylation through reduced HDAC1 expression, resulting in suppressing breast cancer growth. In summary, we uncover a novel mechanism of VPA in regulating the Warburg effect which is essential for developing the effective approach in breast cancer therapy.

scholarly journals Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

2015 ◽  
Vol 21 (1) ◽  
pp. 65-80 ◽  
Author(s):  
Eva M. Palsson-McDermott ◽  
Anne M. Curtis ◽  
Gautam Goel ◽  
Mario A.R. Lauterbach ◽  
Frederick J. Sheedy ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Warburg Effect ◽  
Activated Macrophages ◽  
Critical Determinant ◽  
Pyruvate Kinase M2 ◽  
The Warburg Effect
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