scholarly journals Proliferation inhibition and differentiation induction of hepatic cancer stem cells by knockdown of BC047440: A potential therapeutic target of stem cell treatment for hepatocellular carcinoma

2014 ◽  
Vol 31 (4) ◽  
pp. 1911-1920 ◽  
Author(s):  
NAN YOU ◽  
LU ZHENG ◽  
WEIHUI LIU ◽  
XIAO ZHONG ◽  
WEIWEI WANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Hepatic Cancer ◽  
Proliferation Inhibition ◽  
Potential Therapeutic Target ◽  
Differentiation Induction ◽  
Stem Cell Treatment

scholarly journals Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hyang Sook Seol ◽  
Yoshimitsu Akiyama ◽  
San-Eun Lee ◽  
Shu Shimada ◽  
Se Jin Jang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Xenograft Model ◽  
Mtor Pathway ◽  
Carcinoma Cells ◽  
Stable Cell Line ◽  
Hep3b Cells ◽  
Igf2 Expression

AbstractStemness factors control microRNA expression in cancer stem cells. Downregulation of miR-100 and miR-125b is associated with tumor progression and prognosis of various cancers. Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b are identified to have association with stemness. In TS cells, miR-100 and miR-125b were downregulated comparing to 2D cells. The finding was reproduced in Hep3B cells. Overexpression of stemness factors NANOG, OCT4 and SOX2 by introduction of gene constructs in Hep3B cells suppressed these two miRNA expression levels. Treatment of chromeceptin, an IGF signaling pathway inhibitor, decreased numbers of TS and inhibited the AKT/mTOR pathway. Stable cell line of miR-100 and miR-125b overexpression decreased IGF2 expression and inhibited tumor growth in the xenograft model. In conclusion, miR-100 and miR-125b have tumor suppressor role in hepatocellular carcinoma through inhibiting IGF2 expression and activation of the AKT/mTOR pathway.

scholarly journals Cancer stem cells as a potential therapeutic target in thyroid carcinoma

2016 ◽  
Vol 12 (4) ◽  
pp. 2254-2260 ◽  
Author(s):  
Luisa Vicari ◽  
Cristina Colarossi ◽  
Dario Giuffrida ◽  
Ruggero De Maria ◽  
Lorenzo Memeo
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Thyroid Carcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

BMP4 Administration Induces Differentiation of CD133+ Hepatic Cancer Stem Cells, Blocking Their Contributions to Hepatocellular Carcinoma

2012 ◽  
Vol 72 (16) ◽  
pp. 4276-4285 ◽  
Author(s):  
Lixing Zhang ◽  
Hefen Sun ◽  
Fangyu Zhao ◽  
Ping Lu ◽  
Chao Ge ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Hepatic Cancer

scholarly journals Novel therapeutic target for cancer stem cells in hepatocellular carcinoma

2012 ◽  
Vol 19 (6) ◽  
pp. 600-605 ◽  
Author(s):  
Hiroaki Nagano ◽  
Hideshi Ishii ◽  
Shigeru Marubashi ◽  
Naotsugu Haraguchi ◽  
Hidetoshi Eguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Novel Therapeutic

Wilms Tumor NCAM-Expressing Cancer Stem Cells as Potential Therapeutic Target for Polymeric Nanomedicine

2017 ◽  
Vol 16 (11) ◽  
pp. 2462-2472 ◽  
Author(s):  
Ela Markovsky ◽  
Einav Vax ◽  
Dikla Ben-Shushan ◽  
Anat Eldar-Boock ◽  
Rachel Shukrun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Wilms Tumor ◽  
Potential Therapeutic Target

scholarly journals Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

Stem Cells ◽  
2012 ◽  
Vol 30 (7) ◽  
pp. 1327-1337 ◽  
Author(s):  
Christophe Ginestier ◽  
Florence Monville ◽  
Julien Wicinski ◽  
Olivier Cabaud ◽  
Nathalie Cervera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Breast Cancer Stem Cells ◽  
Potential Therapeutic Target ◽  
Basal Breast Cancer
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