MicroRNA‑129 inhibits colorectal cancer cell proliferation, invasion and epithelial‑to‑mesenchymal transition by targeting SOX4

2021 ◽  
Vol 45 (5) ◽  
Author(s):  
Zhiping Chen ◽  
Tianyu Zhong ◽  
Jinghua Zhong ◽  
Yang Tang ◽  
Baodian Ling ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Mesenchymal Transition

scholarly journals MiR-1-3p Suppresses Colorectal Cancer Cell Proliferation and Metastasis by Inhibiting YWHAZ-Mediated Epithelial–Mesenchymal Transition

2021 ◽  
Vol 11 ◽  
Author(s):  
Guanghong Du ◽  
Xuelian Yu ◽  
Yun Chen ◽  
Wangting Cai
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Mesenchymal Transition ◽  
Proliferation And Metastasis ◽  
Proliferation And Invasion ◽  
Cell Proliferation And Metastasis

BackgroundColorectal cancer (CRC) is regarded as one of the most common malignancies in the world. MiR-1-3p was reported to be a tumor suppressor in CRC. However, the mechanisms have not been fully elucidated.MethodsTo identify CRC-associated miRNA, microarray data set GSE30454 was downloaded from the Gene Expression Omnibus database (GEO), and miR-1-3p was screened out as a candidate. The expression of miR-1-3p was detected using quantitative real-time polymerase chain reaction (qRT-PCR) in CRC cell lines and tissues. CCK-8 assay and transwell invasion assay were performed to determine CRC cell line proliferation and invasion, respectively. The levels of YWHAZ and EMT-associated proteins were detected using western blotting.ResultsBioinformatic analysis showed that miR-1-3p was downregulated in CRC tissues, which is verified by our experimental validation. The overexpression of miR-1-3p significantly suppressed CRC cell proliferation and invasion. Further studies showed that YWHAZ was a direct target of miR-1-3p and mediated epithelial–mesenchymal transition (EMT) modulated by miR-1-3p.ConclusionOur results demonstrated that miR-1-3p suppresses colorectal cancer cell proliferation and metastasis through regulating YWHAZ-mediated EMT, which may support a novel therapeutic strategy for CRC patients.

scholarly journals Regulation of UHRF 1 by micro RNA ‐9 modulates colorectal cancer cell proliferation and apoptosis

2015 ◽  
Vol 106 (7) ◽  
pp. 833-839 ◽  
Author(s):  
Mingchen Zhu ◽  
Yijun Xu ◽  
Mengyuan Ge ◽  
Zhen Gui ◽  
Feng Yan
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Micro Rna ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Proliferation And Apoptosis

Down-Regulated LncRNA-HOTAIR Suppressed Colorectal Cancer Cell Proliferation, Invasion, and Migration by Mediating p21

2018 ◽  
Vol 63 (9) ◽  
pp. 2320-2331 ◽  
Author(s):  
Kai Lin ◽  
Hong Jiang ◽  
Ling-Ling Zhang ◽  
Yi Jiang ◽  
Yu-Xian Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Invasion And Migration ◽  
And Migration ◽  
Lncrna Hotair

miR-34a-5p suppresses colorectal cancer cell proliferation through silencing Microtubule Actin Crosslinking Factor 1 (MACF1) gene

Gene Reports ◽  
2021 ◽  
pp. 101416
Author(s):  
Dalia Abdel-Wahab Mohamed ◽  
Enas Samir Nabil ◽  
Fayda Ibrahim Abdel Motaleb ◽  
Rowaida M. Aboushahba ◽  
Ahmed Abdel Aziz Abou-Zeid ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation

Dietary probiotic and metabolites improve intestinal homeostasis and prevent colorectal cancer

2020 ◽  
Vol 11 (12) ◽  
pp. 10724-10735
Author(s):  
Mengfei Peng ◽  
Seong-Ho Lee ◽  
Shaik O. Rahaman ◽  
Debabrata Biswas
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Lactobacillus Casei ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Intestinal Homeostasis ◽  
Anti Inflammatory

Metabolites from Lactobacillus casei display substantial antioxidant and anti-inflammatory activities, inhibit colorectal cancer cell proliferation and growth, and modulate gut microfloral composition, specifically reducing sulfidogenic bacteria.

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