scholarly journals Solitary lung metastasis from primary prostate cancer with normal prostate specific antigen levels: A case report and literature review

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Natsumi Maru ◽  
Asako Okabe ◽  
Haruaki Hino ◽  
Takahiro Utsumi ◽  
Hiroshi Matsui ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Literature Review ◽  
Prostate Specific Antigen ◽  
Lung Metastasis ◽  
Specific Antigen ◽  
Normal Prostate ◽  
Primary Prostate Cancer

scholarly journals Solitary Lung Metastasis From Primary Prostate Cancer With Normal Prostate Specific Antigen Level: a Case Report and Literature Review

2021 ◽  
Author(s):  
Natsumi Maru ◽  
Asako Okabe ◽  
Haruaki Hino ◽  
Takahiro Utsumi ◽  
Hiroshi Matsui ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Literature Review ◽  
Prostate Specific Antigen ◽  
Lung Metastasis ◽  
Specific Antigen ◽  
Prostate Specific Antigen Level ◽  
Low Grade ◽  
Antigen Level ◽  
Normal Prostate ◽  
Term Survival

Abstract Background: Pulmonary involvement from prostate cancer is a well-known condition, but solitary lung metastasis is rare, with its associated clinical characteristics not yet fully elucidated.Case presentation: A 77-year-old man, with a history of radical prostatectomy for primary prostatic carcinoma 14 years prior, presented to our institution with a low-grade fever. Upon consultation, biochemical recurrence was suspected due to a gradual increase in prostate-specific antigen level. Salvage radiation therapy was considered but not performed since there was no recurrent macroscopic tumor. Computed tomography showed a solitary nodule with spiculation located on the upper lobe of the left lung while positron emission tomography suggested malignancy without metastasis. Based on these findings, primary lung cancer was suspected and thoracoscopic left upper lobectomy with lymph node dissection was performed. Pathological diagnosis of the tumor was a solitary lung metastasis of prostate cancer. The postoperative recovery was uneventful. Conclusion: We report a case with normal prostate-specific antigen level, along with a literature review. According to previous case reports, there are some pitfalls leading misdiagnosis as a primary lung tumor. However, we consider that surgical resection is associated with increased diagnostic accuracy and long-term survival.

scholarly journals Solitary Lung Metastasis of Prostate Cancer with a Long Disease-Free Interval and Normal Prostate-Specific Antigen Level

2021 ◽  
pp. 284-289
Author(s):  
Hiroyuki Yoshitake ◽  
Shoji Oura ◽  
Tomoyuki Yamaguchi ◽  
Shinichiro Makimoto
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Lung Metastasis ◽  
Specific Antigen ◽  
Middle Lobe ◽  
Primary Adenocarcinoma ◽  
Wide Resection ◽  
Normal Prostate ◽  
Solid Nodule

An 83-year-old man with core needle biopsy-proven Gleason score 5 prostate cancer had received radiotherapy including 18 Gy brachytherapy to the prostate cancer, leading to no locoregional and distant recurrence for more than 5 years with the normalization of elevated prostate-specific antigen (PSA) level before the radiotherapy. Due to the enlargement of coexisting ground glass nodule (GGN) in the left lung from 1 to 2.1 cm, the patient underwent wide resection of the GGN 7 years later. Under the diagnosis of adenocarcinoma in situ of the lung, follow-up computed tomography 6 months after the wide resection showed a rapid enlargement of a solid nodule having been judged as a presumed inflammatory nodule in the middle lobe, highly suggesting a malignant neoplasm of the lung. Due to both the tall columnar atypical cells with trabecular pattern on frozen section and no elevation of serum PSA level, we judged the nodule as a primary adenocarcinoma of the lung and further resected the middle lobe with lymph node dissection. Immunostaining of the tumor showed all the CK7, CK20, TTF-1, napsin A, synaptophysin, chromogranin, CD56, CDX2, p53, beta-catenin, and MUC2 negative, and PSA highly positive, clearly showing the solid nodule as a solitary lung metastasis of the prostate cancer. Physicians should note the possible solitary lung metastasis of prostate cancer, especially bearing indolent biology, with no elevation of the PSA level even after the completion of standard 5-year follow-up.

Prostate-Specific Antigen Flare Phenomenon During 223Ra-Dichloride Treatment for Bone Metastatic Castration-Resistant Prostate Cancer: A Case Report

2016 ◽  
Vol 14 (5) ◽  
pp. e529-e533 ◽  
Author(s):  
Giuseppe De Vincentis ◽  
Giulia Anna Follacchio ◽  
Viviana Frantellizzi ◽  
Mauro Liberatore ◽  
Francesco Monteleone ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Castration Resistant Prostate Cancer ◽  
Flare Phenomenon ◽  
Castration Resistant

scholarly journals PRIMARY GASTROINTESTINAL STROMAL TUMOUR OF THE PROSTATE: A CASE REPORT OF A RARE TUMOUR

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
Muhammad Arshad Irshad Khalil ◽  
Nouman Khan ◽  
Azfar Ali ◽  
Khurram Mir
Keyword(s):  
Case Report ◽  
Prostate Specific Antigen ◽  
Bladder Outlet Obstruction ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Rare Tumour ◽  
Normal Prostate

A 70-year-old gentleman underwent prostatectomy for bladder outlet obstruction due to enlarged prostate and was found to have primary extragastrointestinal stromal tumour (EGIST). He has been started on imatinib therapy and is presently on follow-up. Prostatic EGIST should be one of the differential diagnoses in patients with enlarged prostate with normal prostate-specific antigen levels.Key words: Prostate, gastrointestinal stromal tumour, PSA  

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