scholarly journals Phylogenetic Relationships of the Partial G Gene Sequence of Bovine Ephemeral Fever Virus Isolated from Mainland China, Taiwan, Japan, Australia, Turkey and Israel

2012 ◽  
Vol 11 (17) ◽  
pp. 3217-3222 ◽  
Author(s):  
Guozhen Lin ◽  
Changqing Qiu
2009 ◽  
Vol 137 (3-4) ◽  
pp. 217-223 ◽  
Author(s):  
Tomoko Kato ◽  
Maki Aizawa ◽  
Katsunori Takayoshi ◽  
Tamotsu Kokuba ◽  
Tohru Yanase ◽  
...  

2017 ◽  
Vol 162 (11) ◽  
pp. 3555-3558 ◽  
Author(s):  
Shandian Gao ◽  
Junzheng Du ◽  
Zhancheng Tian ◽  
Qingli Niu ◽  
Fuying Zheng ◽  
...  

2019 ◽  
Vol 2 (4) ◽  
pp. 47-60
Author(s):  
Zeinab, T. Salem ◽  
Shendy, M. B. ◽  
Omaima, A. El-Shemindy ◽  
Soliman, A. F. ◽  
Naglaa ,I. Aly

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 601
Author(s):  
Yu-Jing Zeng ◽  
Min-Kung Hsu ◽  
Chiao-An Tsai ◽  
Chun-Yen Chu ◽  
Hsing-Chieh Wu ◽  
...  

During industrial-scale production of viruses for vaccine manufacturing, anti-viral response of host cells can dampen maximal viral antigen yield. In addition to interferon responses, many other cellular responses, such as the AMPK signaling pathway or senescence-like response may inhibit or slow down virus amplification in the cell culture system. In this study, we first performed a Gene Set Enrichment Analysis of the whole-genome mRNA transcriptome and found a senescence-like cellular response in BHK-21 cells when infected with bovine ephemeral fever virus (BEFV). To demonstrate that this senescence-like state may reduce virus growth, BHK-21 subclones showing varying degrees of a senescence-like state were infected with BEFV. The results showed that the BHK-21 subclones showing high senescence staining could inhibit BEFV replication while low senescence-staining subclones are permissive to virus replication. Using a different approach, a senescence-like state was induced in BHK-21 using a small molecule, camptothecin (CPT), and BEFV susceptibility were examined. The results showed that CPT-treated BHK-21 is more resistant to virus infection. Overall, these results indicate that a senescence-like response may be at play in BHK-21 upon virus infection. Furthermore, cell clone selection and modulating treatments using small molecules may be tools in countering anti-viral responses.


2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Ilke Karayel-Hacioglu ◽  
Selda Duran Yelken ◽  
Yaser Vezir ◽  
Nilay Unal ◽  
Feray Alkan

2011 ◽  
Vol 187 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Wen T. Ji ◽  
Ying C. Wang ◽  
Feng L. Lin ◽  
Ming H. Liao ◽  
Wen L. Shih ◽  
...  

Virus Genes ◽  
2020 ◽  
Vol 56 (3) ◽  
pp. 390-395 ◽  
Author(s):  
Jia Kun ◽  
Jia Rongrong ◽  
Wang Xiangbin ◽  
Zhao Yan ◽  
Dou Yiping ◽  
...  

2007 ◽  
Vol 145 (1) ◽  
pp. 84-87 ◽  
Author(s):  
Sue T. Chuang ◽  
Wen T. Ji ◽  
Yu T. Chen ◽  
Chi H. Lin ◽  
Yao C. Hsieh ◽  
...  

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