Antihypertensive Effect of Bauhinia forficata Aqueous Extract in Rats

2013 ◽  
Vol 8 (3) ◽  
pp. 82-89 ◽  
Author(s):  
Paulo Jose Castro do Anjos ◽  
Paulo Roberto Pereira ◽  
Italo Jose Alves Moreira ◽  
Mairim Russo Serafini ◽  
Adriano Antunes Souz Araujo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Bauhinia Forficata

Ruta montana evokes antihypertensive activity through increase of prosta-glandins release in L-NAME-induced hypertensive rats

2020 ◽  
Vol 20 ◽  
Author(s):  
El-Ouady Fadwa ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Antihypertensive Activity ◽  
Computer Assisted ◽  
Hypertensive Rats ◽  
Vasorelaxant Effect ◽  
Vasorelaxant Activity ◽  
Ruta Montana

Aims: The aim of the study was to investigate experimentally the antihypertensive effect of Ruta Montana. Background: Ruta montana L. is traditionally used in Moroccan herbal medicine to treat hypertension. This study aimed to evaluate experimentally the hypotensive and vasoactive properties of this plant. Objective: The objective of the study was to evaluate the effect of the aqueous extract of Ruta Montana on blood pressure parameters in LNAME-induced hypertensive rats and to determine the vasorelaxant activity of this aqueous extract. Methods: The antihypertensive effect of the aqueous extract obtained from Ruta montana aerial parts (RMAPAE) (200 mg/kg) was evaluated in normal and anesthetized hypertensive rats. Blood pressure parameters (systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP)) and heart rate were measured using a tail-cuff and a computer-assisted monitoring device. The acute and chronic effect of RMAPAE was recorded during 6 hours for the acute experiment and during 7 days for the sub-chronic test. In the other set, the vasorelaxant effect of RMAPAE on the contractile response was undertaken in isolated thoracic aorta. Results: The results indicated that RMAPAE extract significantly decreased SBP, MBP, DBP and heart rate in L-NAMEinduced hypertensive rats. Furthermore, RMAPAE was demonstrated to induce a dose dependent relaxation in the aorta precontracted with Epinephrine or KCl. More interestingly, this vasorelaxant activity of RMAPAE seems to be probably mediated through the prostaglandins pathway. Conclusion: The present study illustrates the beneficial action of Ruta montana on hypertension and supports then its use as an antihypertensive agent.

Insulin-like effects of Bauhinia forficata aqueous extract upon Tityus serrulatus scorpion envenoming

2004 ◽  
Vol 95 (2-3) ◽  
pp. 385-392 ◽  
Author(s):  
Flávio Vasconcelos ◽  
Suely V. Sampaio ◽  
Maria A.R. Garófalo ◽  
Luiz Fernando L. Guimarães ◽  
José R. Giglio ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Tityus Serrulatus ◽  
Bauhinia Forficata

Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa

Fitoterapia ◽  
2007 ◽  
Vol 78 (4) ◽  
pp. 292-297 ◽  
Author(s):  
F.B.O. Mojiminiyi ◽  
M. Dikko ◽  
B.Y. Muhammad ◽  
P.D. Ojobor ◽  
O.P. Ajagbonna ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Hibiscus Sabdariffa

Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: An in vivo approach to the hypotensive mechanism

Phytomedicine ◽  
2007 ◽  
Vol 14 (5) ◽  
pp. 314-320 ◽  
Author(s):  
M.T.R. Lima-Landman ◽  
A.C.R. Borges ◽  
R.M. Cysneiros ◽  
T.C.M. De Lima ◽  
C. Souccar ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect

scholarly journals Preclinical Evaluation of the Antihypertensive Effect of an Aqueous Extract of Anogeissus leiocarpa (DC) Guill et Perr. Bark of Trunk in L-NAME-Induced Hypertensive Rat

2021 ◽  
Vol Volume 13 ◽  
pp. 739-754
Author(s):  
Lazare Belemnaba ◽  
Mathieu Nitiéma ◽  
Sylvain Ilboudo ◽  
Gueswindé Geoffroy Ouédraogo ◽  
Noufou Ouédraogo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Preclinical Evaluation ◽  
Hypertensive Rat

scholarly journals Aqueous Extract of Zingiber officinale Roscoe Rhizomes Sold in Ouagadougou Markets: Phytochemical Constituents, Effect on Arterial Pressure and Blood Biochemical Parameters of Wistar Rats

2020 ◽  
pp. 50-58
Author(s):  
Larba Colette Tougouma ◽  
Youssoufou Ouédraogo ◽  
Abel Andouormwine Somé ◽  
Lazare Belemnaba
Keyword(s):  
Arterial Pressure ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Antihypertensive Effect ◽  
Colorimetric Method ◽  
Zingiber Officinale ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Phytochemical Constituents

The aim of this study was to exhibit cardiovascular effects of aqueous extract of Zingiber officinale rhizome sold in Ouagadougou markets (Burkina Faso). Phytochemical constituents and some blood biochemical parameters were also investigated. Colorimetric method was used for phytochemical screening. Extract was prepared and orally administered on Wistar rats. Arterial pressure and cardiac rhythm were measured using Ugo Basile Blood Pressure Recorder 58500. Biochemical parameters were performed using Mindray BA-88A, Semi-auto Chemistry Analyzer. Triterpenes and/or sterols, and saponosides were present in aqueous extract of the plant. We also found very significative hypotension effect on rat mean arterial pressure, when plant extract was administered at 400 mg/kg bw (p ˂ 0.01). When extract was administered after a hypertension induced by L-NAME, we observed a high significative antihypertensive effect (p ˂ 0.001) at 200 and 400 mg/kg bw. This effect was comparable to captopril inhibition of L-NAME induced hypertension. However, in all cases, we did not observe any significative variation of heart rate. For biochemical parameters, we did not find any effect, excepted a significant increase of phosphoremia at 400 mg/kg bw and after L-NAME administration (highly significant). Our results confirm literature data and corroborate traditional uses of Z. officinale sold in Ouagadougou markets. They suggest that antihypertensive effect of AEZO is mainly supported by vascular physiology components.

scholarly journals Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark ofMammea africanaSabine (Guttiferae)

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Elvine Pami Nguelefack-Mbuyo ◽  
Alain Bertrand Dongmo ◽  
Télesphore Benoît Nguelefack ◽  
Albert Kamanyi ◽  
Pierre Kamtchouing ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Response Curve ◽  
Wistar Rats ◽  
Antihypertensive Effect ◽  
Stem Bark ◽  
Male Wistar Rats ◽  
Vasorelaxant Activity ◽  
Concentration Response Curve

This study evaluates the vasorelaxant and antihypertensive effects of the aqueous extract from the stem bark ofM. africana(AEMA). AEMA was testedin vitroon intact or endothelium-denuded rats’ aorta rings precontracted with KCl or norepinephrine in absence or in presence of L-NAME or glibenclamide. The effect of a single concentration (300 μg/mL) of AEMA was also examined on the concentration-response curve of KCl.In vivo, the antihypertensive effects of AEMA (200 mg/kg/day) were evaluated in male Wistar rats treated with L-NAME (40 mg/kg/day) for 4 weeks. AEMA relaxed aorta rings precontracted with NE or KCl with respective EC50 values of 0.36 μg/mL and 197.60 μg/mL. The destruction of endothelium or pretreatment of aorta rings with L-NAME shifted the EC50 of AEMA from 0.36 μg/mL to 40.65 μg/mL and 20.20 μg/mL, respectively. The vasorelaxant activity ofM. africanawas significantly inhibited in presence of glibenclamide. AEMA also significantly inhibited the concentration-response curve of KCl. Administered orally, AEMA induced acute and chronic antihypertensive effects and normalized renal NO level. These results show that the vasorelaxant activity of AEMA might be mediated by the activation of the NO-cGMP-ATP-dependent potassium channels pathway and might predominantly account for its antihypertensive effect.

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